demethyltuberin | 98244-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: demethyltuberin
• 英文别名: N-[2-(4-hydroxyphenyl) ethenyl]formamide；N-[2-(4-hydroxyphenyl)ethenyl]formamide
• CAS: 98244-37-2
• 化学式: C₉H₉NO₂
• 分子量: 163.176
• InChiKey: SOUPPVGWCZENNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  tuberin 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到demethyltuberin
  参考文献：
  名称：

  Cable, Karl M.; Herbert, Richard B.; Mann, Jonathan, Journal of the Chemical Society. Perkin transactions I, 1987, p. 1593 - 1598

  摘要：

  DOI：

文献信息

• Improvement in the total synthesis of Erbstatin analogs
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0440887A1

  公开（公告）日：1991-08-14

  The present invention relates to a new process for the preparation of Erbstatin and Erbstatin analogs, which can be represented by the following formula (I) wherein R is hydrogen, a lower alkyl or a lower alkanoyl group; n is an integer of 1 to 3; A is -CH=CH- or -CH₂-CH₂-; R₁ is hydrogen or a lower alkyl group, and R₂ is a hydrogen or halogen atom,

  本发明涉及一种制备厄布司他汀和厄布司他汀类似物的新工艺，其可由下式（I）表示 其中 R 是氢、低级烷基或低级烷酰基； n 是 1 至 3 的整数； A 是-CH=CH-或-CH₂-CH₂-； R₁ 是氢或低级烷基，以及 R₂ 是氢原子或卤素原子、
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Antibacterial activity of N-(.beta.-styryl)formamides related to tuberin
  作者：Ian T. Harrison、Walter Kurz、Ian J. Massey、Stefan H. Unger

  DOI：10.1021/jm00204a017

  日期：1978.6

  A series of para-substituted N-(beta-styryl)formamides, analogues of tuberin (4a), has been prepared and assayed for antibacterial activity. The methylthio, ethoxy, and methyl analogues 4e, 4j, and 4t were about twice as active as tuberin against Mycobacterium phlei. Although tuberin lacks activity against Staphylococcus aureus, several of the analogues described were found to inhibit this organism. The phenyl group of tuberin is not a prerequisite for activity since analogues based on naphthyl or ferrocenyl groups were also active. A quantitative structure-activity relationship further implied that an aromatic group need not be present, suggesting the synthesis of the cyclohexyl and n-amyl analogues which were found to possess high activity.
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：enEvolv, Inc.

  公开号：EP3027754A1

  公开（公告）日：2016-06-08
• JPS59175891A
  申请人：——

  公开号：JPS59175891A

  公开（公告）日：1984-10-04