(7-isopropoxy-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (7-isopropoxy-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetic acid
• 英文别名: 2-(4,8-dimethyl-2-oxo-7-propan-2-yloxychromen-3-yl)acetic acid
• 化学式: C₁₆H₁₈O₅
• mdl: MFCD03851261
• 分子量: 290.31
• InChiKey: SZSIOVMTHFGRAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SLC26A3 INHIBITORS AND USE THEREOF
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20210363123A1

  公开（公告）日：2021-11-25

  Provided herein are inhibitors of SLC26A3, which is an anion (CV, HCO 3 , oxalate) exchanger expressed in intestinal epithelial cells. SLC26A3 inhibitors have potential utility for treatment of constipation including chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), constipation-predominant irritable bowel syndrome (IBS-C), cystic fibrosis-associated constipation, meconium ileus, distal intestinal obstruction syndrome, calcium oxalate kidney stone disease, enteric hyperoxaluria and primary hyperoxalurias.