Confluentinsaeure | 6009-12-7

• 物质功能分类: 天然产物 - 酚类
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Confluentinsaeure
• 英文别名: confluentic acid；4-[2-hydroxy-4-methoxy-6-(2-oxoheptyl)benzoyl]oxy-2-methoxy-6-pentylbenzoic acid
• CAS: 6009-12-7
• 化学式: C₂₈H₃₆O₈
• 分子量: 500.589
• InChiKey: UANVCGQMNRTKGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  36
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Confluentinsaeure 在 水 、 potassium hydroxide 作用下， 生成 8-hydroxy-6-methoxy-3-pentylisocoumarin 、 2-O-Methylolivetolcarbonsaeure
  参考文献：
  名称：

  Intramolecular transesterification of depsides yields fluorescent 1H-isochromen-1-ones: Application as a chemical probe for lichen determination

  摘要：

  DOI：

  10.1016/j.phytochem.2022.113139

文献信息

• Tert-butanolysis of lichen depsides
  作者：Siegfried Huneck

  DOI：10.1016/s0031-9422(00)84138-2

  日期：1984.1
• Huneck, Chemische Berichte, 1962, vol. 95, p. 328,331
  作者：Huneck

  DOI：——

  日期：——
• Thyroid volumes in schoolchildren of Tehran: Comparison with European schoolchildren
  作者：Fereidoun Azizi、H. Delshad、Y. Mehrabi

  DOI：10.1007/bf03343924

  日期：2001.11

  Since the normative values of thyroid volume ultrasonography results from European schoolchildren were endorsed by the World Health Organization (WHO), few studies have addressed the limitation of the recommended references as universal normative values for thyroid volume. Our objective was to describe thyroid volume measured by ultrasonography in Tehranian schoolchildren and compare them with the WHO normative values. Cross-sectional studies were performed in 2016 schoolchildren, aged 6-15 yr, in Tehran 10 yr after distribution of iodized salt. Data were collected on age, sex, weight, height, thyroid size by palpation and ultrasonography, and urinary iodine. Age/sex and body surface area (BSA) upper limits (97(th) percentile) of thyroid volume were derived. The goiter prevalence was 42% by palpation, 31% grade 1 and 11% grade 2. Median urinary iodine was 21.2 mug/dl. The 97(th) percentiles were comparable in girls and boys of all ages. Applying the WHO thyroid volume references to the Tehranian children, they did not show any enlarged thyroid based on BSA and on age, even in 11% of children with grade 2 (visible) goiter. In the Tehranian children, the best predictors of thyroid volume were BSA, height and weight. Using linear regression, the 97(th) percentile of thyroid volume from Tehranian children were lower than the corresponding references from the WHO normative values. The results indicate that a thyroid volume reference based on weight alone would perform as well as the one based on BSA. In addition, until the adoption of a new applicable international reference for thyroid volume, the use of local reference in the screening of children for thyroid enlargement is recommended. (C) 2001, Editrice Kurtis.
• Intramolecular transesterification of depsides yields fluorescent 1H-isochromen-1-ones: Application as a chemical probe for lichen determination
  作者：S. Ferron、P. Jéhan、X. Guillory、P. Uriac

  DOI：10.1016/j.phytochem.2022.113139

  日期：2022.6