2-(3,4-dimethoxyphenyl)-3-methyloxirane | 40626-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,4-dimethoxyphenyl)-3-methyloxirane
• 英文别名: 4-(1,2-epoxy-propyl)-1,2-dimethoxy-benzene；4-(1,2-Epoxy-propyl)-1,2-dimethoxy-benzol
• CAS: 40626-39-9
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: UCJMTGYVYMNVLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  277.9±40.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  31
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3,4-dimethoxyphenyl)-3-methyloxirane 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Fourneau; Tiffeneau, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905, vol. 141, p. 662

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(3,4-dimethoxyphenyl)-2-bromopropan-1-ol 在 氢氧化钾 作用下， 生成 2-(3,4-dimethoxyphenyl)-3-methyloxirane
  参考文献：
  名称：

  Mannich; Jacobsohn, Chemische Berichte, 1910, vol. 43, p. 193

  摘要：

  DOI：

文献信息

• Formal [3+2] Cycloaddition Reactions of Electron-Rich Aryl Epoxides with Alkenes under Lewis Acid Catalysis Affording Tetrasubstituted Tetrahydrofurans
  作者：Víctor E. Macías-Villamizar、Luís Cuca-Suárez、Santiago Rodríguez、Florenci V. González

  DOI：10.3390/molecules25030692

  日期：——

  We report on the regio- and stereoselective synthesis of tetrahydrofurans by reaction between epoxides and alkenes in the presence of a Lewis acid. This is an unprecedented formal [3+2] cycloaddition reaction between an epoxide and an alkene. The chemical reaction represents a very concise synthesis of tetrahydrofurans from accessible starting compounds.

  我们报告了通过环氧化物和烯烃在路易斯酸存在下反应的四氢呋喃的区域选择性和立体选择性合成。这是环氧化物和烯烃之间前所未有的正式 [3+2] 环加成反应。该化学反应代表了从易得的起始化合物非常简洁地合成四氢呋喃。
• Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines
  作者：Martin H. Bolli、Steven V. Ley

  DOI：10.1039/a803612h

  日期：——

  An efficient combinatorial access to β-hydroxyamines suitable for automation is achieved by the mild oxidation of alcohols to aldehydes by polymer supported perruthenate (PSP), the subsequent clean olefination of the obtained aldehydes by polymer supported Wittig reagents followed by the epoxidation of the olefins by dimethyldioxirane (DMDO), and the final aminolysis of the epoxides with various amines is described.

  通过聚合物负载高铼酸盐（PSP）将醇温和氧化为醛，随后使用聚合物负载的Wittig试剂对所得醛进行清洁的烯化反应，接着用二甲基二氧杂环丙烷（DMDO）对烯烃进行环氧化，最后用各种胺对环氧化物进行胺解反应，实现了一种适用于自动化的β-羟基胺的高效组合合成方法。
• Oxidation of isosafrole by sodium hypochlorite catalysed by manganese porphyrins: Unusual competition between epoxidation and O-dealkylation
  作者：Luisella Bocchio Chiavetto、Gianfranco Guglielmetti、Cecilia Querci、Marco Ricci

  DOI：10.1016/0040-4039(95)02312-7

  日期：1996.2

  isosafrole (1a) and isoeugenol methyl ether (1b), two closely related substrates, behave very differently when subjected to manganese porphyrins catalysed epoxidation by sodium hypochlorite. A possible explanation is given, in terms of an unusual competition between the epoxidation and the O-dealkylation of the OCH2O moiety.

  异黄樟醇（1a）和异丁香酚甲基醚（1b）是两个密切相关的底物，当受到锰卟啉催化的次氯酸钠环氧化时，其行为有很大不同。一种可能的解释给出，在环氧化和OCH的O-脱烷基化之间的不寻常的竞争方面2 O部分。
• Clay catalized rearrangement of phenyloxiranes
  作者：Roberto Martínez、Micaela Velasco、Ignacio Martínez、Italo Menconi、Alberto Ramfrez、Enrique Angeles、Ignacio Regla、Rafael López

  DOI：10.1002/jhet.5570340638

  日期：1997.11

  The reaction of phenyloxiranes with a clay produces aldehydes, ketones and cyclic ethers. This method has the advantage that experimental conditions are simple and the reagents used are cheaper.

  苯氧杂环丁烷与粘土的反应生成醛，酮和环状醚。该方法的优点是实验条件简单并且所用试剂便宜。
• Reactive radiation- or thermally- initiated cationically-curable epoxide monomers and compositions made from those monomers
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP0878472A1

  公开（公告）日：1998-11-18

  Radiation- or thermally-initiated cationically-curable styrene oxides of the structure are suitable for use in cationically curable adhesive and coating compositions.

  结构的辐射或热引发阳离子固化苯乙烯氧化物 适用于阳离子固化粘合剂和涂料组合物。