4-Methylumbelliferyl N,N-diacetyl-beta-D-chitobioside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-Methylumbelliferyl N,N-diacetyl-beta-D-chitobioside
• 英文别名: N-[2-[5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C₂₆H₃₄N₂O₁₃
• 分子量: 582.6
• InChiKey: UPSFMJHZUCSEHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  223
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• NOVEL COMPOSITIONS AND THERAPEUTIC METHODS
  申请人：AyuVis Research LLC

  公开号：US20170281667A1

  公开（公告）日：2017-10-05

  The present invention is directed to novel products, variants, pharmaceutically acceptable salts and prodrugs thereof, and medical use of such compounds for the treatment and/or management of sepsis, septicemia, septic shock, ocular infection, ocular inflammation, ocular angiogenesis, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel diseases (IBD), asthma, chronic obstructive pulmonary disease, fever syndromes, cachexia, psoriasis, autoimmune diseases, cardiac diseases, retinoblastoma, cancer and/or any disorder associated with inflammation, immunomodulation and microbial infection.

  本发明涉及新产品、变体、药用可接受的盐和前药，以及这些化合物的医学用途，用于治疗和/或管理败血症、败血症、脓毒性休克、眼部感染、眼部炎症、眼部血管生成、类风湿性关节炎（RA）、动脉粥样硬化、炎症性肠病（IBD）、哮喘、慢性阻塞性肺病、发热综合征、消瘦症、牛皮癣、自身免疫疾病、心脏疾病、视网膜母细胞瘤、癌症和/或任何与炎症、免疫调节和微生物感染有关的疾病。
• Compositions and therapeutic methods
  申请人：AyuVis Research LLC

  公开号：US11207343B2

  公开（公告）日：2021-12-28

  The present invention is directed to novel products, variants, pharmaceutically acceptable salts and prodrugs thereof, and medical use of such compounds for the treatment and/or management of sepsis, septicemia, septic shock, ocular infection, ocular inflammation, ocular angiogenesis, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel diseases (IBD), asthma, chronic obstructive pulmonary disease, fever syndromes, cachexia, psoriasis, autoimmune diseases, cardiac diseases, retinoblastoma, cancer and/or any disorder associated with inflammation, immunomodulation and microbial infection.

  本发明涉及其新型产品、变体、药学上可接受的盐类和原药，以及此类化合物在治疗和/或控制败血症、脓毒血症、败血性休克、眼部感染、眼部炎症、眼部血管生成、类风湿性关节炎（RA）、动脉粥样硬化、哮喘、慢性阻塞性肺病、发热综合征、恶病质、银屑病、自身免疫性疾病、心脏疾病、牛皮癣等疾病方面的医学用途、动脉粥样硬化、炎症性肠病（IBD）、哮喘、慢性阻塞性肺病、发热综合征、恶病质、银屑病、自身免疫性疾病、心脏病、视网膜母细胞瘤、癌症和/或任何与炎症、免疫调节和微生物感染相关的疾病。