8-acetyl-4,9-dimethyl-2H-furo[2,3-h]chromen-2-one ketoxime

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8-acetyl-4,9-dimethyl-2H-furo[2,3-h]chromen-2-one ketoxime
• 英文别名: 8-(N-hydroxy-C-methylcarbonimidoyl)-4,9-dimethylfuro[2,3-h]chromen-2-one
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: VEUCARGUUJVDOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-乙酰基-7-羟基-4-甲基-2H-1-苯并吡喃-2-酮 在 吡啶 、 盐酸羟胺 、 potassium carbonate 作用下， 以 乙醇 、 乙腈 为溶剂， 生成 8-acetyl-4,9-dimethyl-2H-furo[2,3-h]chromen-2-one ketoxime
  参考文献：
  名称：

  Dependence of Fluorescence Properties of Compounds from Psoralen, Angelicin, and Carbazole Series on the Character of Their Terminal Substituents

  摘要：

  Absorption, luminescence excitation and emission spectra of nine compounds from 4,8,4'-tri-methylpsoralen, 4,4'-dimethylangelicin, and 1,2,3,4-tetrahydrocarbazole series with various terminal substituents were studied in water and 2-propanol. Proceeding from the data obtained in the present and also some previous studies we have formulated the main rules concerning a general mechanism of changes in the fluorescence characteristics of DNA-specific dyes depending on their chemical structure, substrate properties, and measurement medium.

  DOI：

  10.1023/b:rujo.0000003169.96393.1d