6-Hydroxyskimmin | 531-58-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6-Hydroxyskimmin
• 英文别名: 6-hydroxy-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
• CAS: 531-58-8
• 化学式: C₁₅H₁₆O₉
• 分子量: 340.28
• InChiKey: WNBCMONIPIJTSB-UHFFFAOYSA-N

物化性质

• 熔点：
  213-215° (after drying in desiccator)
• 比旋光度：
  D18 -105° (c = 3 in 50% dioxane)
• 沸点：
  697.7±55.0 °C(Predicted)
• 密度：
  1.679±0.06 g/cm3(Predicted)
• LogP：
  -2.450 (est)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  9

安全信息

• WGK Germany：
  3
• 储存条件：
  2-8°C，存放在干燥、密封的环境中。

制备方法与用途

菊苣素是一种具有抗SARS-CoV-2活性的化合物，可能成为治疗重症新冠肺炎的潜在候选药物。

文献信息

• METHODS FOR DIRECTING DIFFERENTIATION OF CLONOGENIC NEURAL STEM CELLS WITH COUMARINS
  申请人：HE Cheng

  公开号：US20090170930A1

  公开（公告）日：2009-07-02

  A method for promoting differentiation of clonogenic neural stem cells (NSCs), comprising administering to a patient in the need of such promoting a coumarin compound represented by formula I or by formula II. The representative coumarin compounds include 7-hydroxycoumarin, daphnoretin, scopoletin, edgeworin, aesculetin and esculetin-6-β-D-glucopyranoside. The coumarin compounds showed significant activity of directing the differentiation of NSCs in pharmacological test and thereof could be used to prepare drugs to direct NSCs differentiated to oligodendrocyte progenitor cells (OPCs) for the treatment of demyelinating diseases or spinal cord injury. The drug could be a pure coumarin compound or a pharmaceutical composition comprising a therapeutical dose of a coumarin compound as active ingredients and a pharmaceutically-acceptable carrier. The content of the active ingredients in the pharmaceutical composition is between 0.1% and 99.5% by weight.