methyl 1-(2-nitro-1-O-tolylethyl)-2-oxocyclopentanecarboxylate | 1092784-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 1-(2-nitro-1-O-tolylethyl)-2-oxocyclopentanecarboxylate
• 英文别名: methyl (1R)-1-[(1S)-1-(2-methylphenyl)-2-nitroethyl]-2-oxocyclopentane-1-carboxylate
• CAS: 1092784-88-7
• 化学式: C₁₆H₁₉NO₅
• 分子量: 305.331
• InChiKey: XLTAPAIHJSPUGI-XJKSGUPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl-2 β-nitrostyrene 、 2-甲氧羰基环戊酮 在 N-[（1R，2R）-2-（二甲基氨基）环己基]-N''-[（1R，2S）-2-羟基-1,2-二苯乙基]硫脲 作用下， 以 二氯甲烷 为溶剂， 生成 methyl 1-(2-nitro-1-O-tolylethyl)-2-oxocyclopentanecarboxylate 、 methyl 1-(2-nitro-1-O-tolylethyl)-2-oxocyclopentanecarboxylate
  参考文献：
  名称：

  带有多个氢键供体的微调有机催化剂，用于通过迈克尔反应构建相邻的四级和三级立体中心。

  摘要：

  DOI：

  10.1002/chem.200801420

文献信息

• <i>C</i>₃-Symmetric Chiral Trisimidazoline: Design and Application to Organocatalyst
  作者：Kenichi Murai、Shunsuke Fukushima、Shoko Hayashi、Yusuke Takahara、Hiromichi Fujioka

  DOI：10.1021/ol902958m

  日期：2010.3.5

  C3-symmetric chiral trisimidazoline was designed and synthesized as a new entry of organocatalyst with the concept of constructing C3-symmetric molecules with three C2-symmetric chiral components, and the application of this novel catalyst to asymmetric conjugate addition of β-ketoesters to nitroolefins was described.

  设计并合成C 3对称手性三咪唑啉作为有机催化剂的一个新入口，其概念是构建具有三个C 2对称手性组分的C 3对称分子，并将该新型催化剂用于β-酮酸酯的不对称共轭加成中描述了对硝基烯烃的“三聚体”。
• Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins
  作者：Isiaka Alade Owolabi、Madhu Chennapuram、Chigusa Seki、Yuko Okuyama、Eunsang Kwon、Koji Uwai、Michio Tokiwa、Mitsuhiro Takeshita、Hiroto Nakano

  DOI：10.1246/bcsj.20180302

  日期：2019.3.15

  Asymmetric Michael addition of β-keto esters with trans-β-nitroolefins using chiral amino amide organocatalyst was tried and afforded synthetically useful chiral Michael adducts in both excellent c...

  使用手性氨基酰胺有机催化剂尝试了β-酮酯与反式-β-硝基烯烃的不对称迈克尔加成，并以两种优异的方式提供了合成有用的手性迈克尔加合物。
• Fine‐Tunable Organocatalysts Bearing Multiple Hydrogen‐Bonding Donors for Construction of Adjacent Quaternary and Tertiary Stereocenters via a Michael Reaction
  作者：Zhi‐Hai Zhang、Xiu‐Qin Dong、Dong Chen、Chun‐Jiang Wang

  DOI：10.1002/chem.200801420

  日期：2008.10.10
• C3-Symmetric chiral trisimidazoline: the role of a third imidazoline and its application to the nitro Michael reaction and the α-amination of β-ketoesters
  作者：Kenichi Murai、Shunsuke Fukushima、Akira Nakamura、Masato Shimura、Hiromichi Fujioka

  DOI：10.1016/j.tet.2011.05.005

  日期：2011.7

  We describe the necessity of the C-3-symmetry and the role of a third imidazoline of trisimidazoline 3, which was recently developed by us as a new entry of organocatalyst. The utility of 3 as a Bronsted base catalyst in the nitro Michael reaction and the alpha-amination of beta-ketoesters was shown, and the re-cyclability of the catalyst was also demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.