4-cyano-N-m-tolylbenzamide | 454470-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-cyano-N-m-tolylbenzamide
• 英文别名: 4-cyano-N-(3-methylphenyl)benzamide
• CAS: 454470-41-8
• 化学式: C₁₅H₁₂N₂O
• mdl: MFCD04530985
• 分子量: 236.273
• InChiKey: HCTDLIOIUHLUDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氰基苯甲酰氯 、 3-甲基苯胺 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以92%的产率得到4-cyano-N-m-tolylbenzamide
  参考文献：
  名称：

  Identification of a potent and noncytotoxic inhibitor of melanin production

  摘要：

  On the basis of a hit from random screening, biaryl amide derivatives were prepared in a combinatorial manner via parallel solution-phase synthesis, and their effects on melanocytes were investigated to discover new effective skin depigmenting agents. Among the 120 derivatives prepared, five members exhibited a >30% reduction of melanin production at 30 mu M with a cell viability of >90%. In particular, compound A(3)/B-5 exhibited effective inhibitory activity on melanin synthesis. Although the inhibition percentage of A(3)/B-5 was slightly lower than that of the positive reference compound, phenylthiourea (PTU), A(3)/B-5 demonstrated a much better cell viability than PTU. In vivo evaluation of A(3)/B-5 also showed a significant decrease of melanin pigments. In addition, the in silico classification model was built based on the experimental data of library members. Our results suggest that these biaryl amide derivatives may act as potent skin depigmenting agents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.034

文献信息

• NOVEL BIARYLAMIDE DERIVATIVE AND COMPOSITIONS CONTAINING THE DERIVATIVE AS AN ACTIVE INGREDIENT
  申请人：Shin Dong Heon

  公开号：US20120289595A1

  公开（公告）日：2012-11-15

  The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.

  本发明涉及一种新型二芳基酰胺衍生物，以及包含其作为活性成分的制药组合物或化妆品组合物。更具体地，本发明涉及一种新型二芳基酰胺衍生物，以及包含其作为活性成分的制药组合物或化妆品组合物，用于预防或治疗由于黑色素异常过多引起的色素沉着障碍或由黑色素细胞增生引起的疾病。本发明的二芳基酰胺衍生物抑制黑色素的生成，从而抑制黑色素细胞增生。因此，包含该二芳基酰胺的化妆品组合物具有出色的美白效果，包含该二芳基酰胺的制药组合物对皮肤色素沉着障碍如雀斑、黄褐斑等和恶性黑色素瘤的预防或治疗具有良好的效果。
• INK FOR INK JET RECORDING, INK JET RECORDING METHOD, INFRARED READING METHOD, AND PRINTED PRODUCT
  申请人：FUJIFILM Corporation

  公开号：EP3502198A1

  公开（公告）日：2019-06-26

  Provided is an ink jet recording ink including: a colorant represented by the following Formula 1, in which an absorption maximum of a dry material of the ink jet recording ink is 700 nm to 1000 nm.

  本发明提供了一种喷墨记录墨水，包括：由下式 1 表示的着色剂，其中喷墨记录墨水干物质的吸收最大值为 700 纳米至 1000 纳米。
• CONDENSED HETEROARYL DERIVATIVES
  申请人：Astellas Pharma Inc.

  公开号：EP1277738B1

  公开（公告）日：2011-03-30
• EP3757179A1
  申请人：——

  公开号：EP3757179A1

  公开（公告）日：2020-12-30
• Fused heteroaryl derivatives
  申请人：Hayakawa Masahiko

  公开号：US20070037805A1

  公开（公告）日：2007-02-15

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.