Toyocamycin nucleoside | 606-58-6

• 物质功能分类: 生物 - 分析对照品、标准品
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: Toyocamycin nucleoside
• 英文别名: 4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• CAS: 606-58-6
• 化学式: C₁₂H₁₃N₅O₄
• 分子量: 291.26
• InChiKey: XOKJUSAYZUAMGJ-UHFFFAOYSA-N

物化性质

• 熔点：
  243°; mp 239-243°
• 比旋光度：
  D16 -45.7° (c = 1.05 in 0.1N HCl)
• 沸点：
  433.28°C (rough estimate)
• 密度：
  1.3067 (rough estimate)
• 溶解度：
  DMSO：可溶0.90 - 1.10mg/mL，透明，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 储存条件：
  -20°C

制备方法与用途

用途

丰加霉素是一种由放线菌产生的腺苷类似物，是 X 盒结合蛋白 1 (XBP1) 抑制剂。它能够抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，其 IC50 值为 80 nM，并能诱导凋亡过程。值得注意的是，丰加霉素对 IRE1α 的自身磷酸化没有影响。

靶点

IC50: 80 nM (XBP1 activation)

文献信息

• PREVENTION OF VASCULAR AND CARDIAC FIBROSIS VIA IRE1ALPHA INHIBITION
  申请人：McMaster University

  公开号：US20190038597A1

  公开（公告）日：2019-02-07

  Provided herein are methods and compositions for treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition in a subject. In one embodiment, the method comprises administering an effective amount of an IRE1α inhibitor to the subject; wherein the subject is identified as having a risk of developing and/or a need for treatment of the condition associated with fibrosis and/or collagen deposition.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING FAT METABOLISM<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES PERMETTANT DE MODULER LE METABOLISME DES GRAISSES
  申请人：OBETHERAPY BIOTECHNOLOGY

  公开号：WO2004037159A2

  公开（公告）日：2004-05-06

  Methods, compositions and methods of identifying candidate compounds, for modulating fat metabolism and/or inhibiting Apobec-1 activity are provided.
• [EN] POLYPEPTIDES HAVING NITRILE HYDRATASE ACTIVITY AND POLYNUCLEOTIDES ENCODING THE SAME<br/>[FR] POLYPEPTIDES POSSÉDANT UNE ACTIVITÉ NITRILE HYDRATASE ET POLYNUCLÉOTIDES CODANT POUR CEUX-CI
  申请人：ARIZONA BOARD OF REGENTS FOR THE UNIVERSITY OF ARIZONA

  公开号：WO2015120314A1

  公开（公告）日：2015-08-13

  The present invention provides isolated polypeptides having nitrile hydratase activity and isolated polynucleotides encoding said polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising said polynucleotides as well as methods of producing and using said polypeptides.