novobiocin | 1021683-67-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: novobiocin
• 英文别名: [5-Hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate
• CAS: 1021683-67-9
• 化学式: C₃₁H₃₆N₂O₁₁
• 分子量: 612.634
• InChiKey: YJQPYGGHQPGBLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  196
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES
  申请人：Blagg Brian S. J.

  公开号：US20120252745A1

  公开（公告）日：2012-10-04

  The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.

  本公开提供了具有替代noviose的诺维菌素类似物，其在癌症治疗中作为Hsp90抑制剂是有用的。
• Methods of treatment for bacterial infections
  申请人：President and Fellows of Harvard College

  公开号：US11191773B2

  公开（公告）日：2021-12-07

  This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.

  本发明的特点是采用了新的组合物和方法，可用于治疗患有革兰氏阴性细菌感染的宿主。本发明公开了由氨基香豆素化合物和多粘菌素化合物组成的组合疗法，包括某些表现出协同效应的组合。此外，还描述了氨基香豆素化合物对革兰氏阴性细菌DNA回旋酶的抑制作用发生改变，和/或能够靶向负责在革兰氏阴性细菌外膜中组装脂多糖的转运蛋白。
• DYNAMIC INHIBITORS OF HEAT SHOCK PROTEIN 90
  申请人：Blagg Brian S.J.

  公开号：US20120309702A1

  公开（公告）日：2012-12-06

  An inhibitor of heat shock protein 90 (HSP90) can include a coumermycin A1 analog having a structure that inhibits HSP90 greater than coumermycin A1. That is, the coumermycin A1 analog is not coumermycin A1. The coumermycin A1 analog can have an antiproliferative biological activity, which can be superior to coumermycin A1. The activity can include the coumermycin A1 analog inhibiting a C-terminus of HSP90.
• METHODS OF TREATMENT FOR BACTERIAL INFECTIONS
  申请人：President and Fellows of Harvard College

  公开号：US20200163985A1

  公开（公告）日：2020-05-28

  This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
• COMPOSITIONS AND METHODS FOR TREATING HUANGLONGBING DISEASE IN CITRUS
  申请人：NEW LIFE CROP SCIENCES LLC

  公开号：US20210144998A1

  公开（公告）日：2021-05-20

  The subject invention pertains to compositions and methods for controlling and/or treating citrus greening in citrus plants, such as orange trees, grapefruit trees, lime trees, lemon trees and the like. The compositions include fertilizers and liquid formulations.