4,6-dimethyl-1,3-dioxane | 26864-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 4,6-dimethyl-1,3-dioxane
• 英文别名: 4,6-Dimethyl-1,3-dioxan
• CAS: 26864-43-7
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: OCBJIXQOIASAQK-UHFFFAOYSA-N

物化性质

• 沸点：
  125.8±8.0 °C(Predicted)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 4,6-dimethyl-1,3-dioxane 在 strong acid 作用下， 生成 (3-Hydroxymethoxy-1-methyl-butoxy)-methanol
  参考文献：
  名称：

  Tavernier, D.; Hosten, N.; Anteunis, M. J. O., Bulletin des Societes Chimiques Belges, 1982, vol. 91, # 10, p. 845 - 864

  摘要：

  DOI：
• 作为产物：
  描述：

  二氧化碳 、 2,4-戊二醇 在 aluminium(III) triflate 、 [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)] 、 氢气 作用下， 以 1,4-二氧六环 为溶剂， 80.0 ℃ 、8.0 MPa 条件下， 反应 18.0h， 生成 4,6-dimethyl-1,3-dioxane
  参考文献：
  名称：

  二氧化碳，氢气和生物质衍生的二元醇的联合利用，钌催化合成环状和线性缩醛。

  摘要：

  本文提出了一种过渡金属催化剂体系，该体系可通过二氧化碳，分子氢和生物质衍生的二醇的综合利用来选择性合成环状和线性缩醛。对底物范围的详细研究使反应的选择性得到了很大的指导，并证明了整合多种底物分子的可能性。该方法允许在有利的环状缩醛和线性缩醛的形成之间进行改变，这源于两种二醇与基于二氧化碳的亚甲基单元的桥接。通过最近建立的将可再生能源，二氧化碳和生物质直接催化转化的“生物混合”方法，这种新的合成方法为新型燃料，溶剂或聚合物构件铺平了道路。

  DOI：

  10.1002/chem.201901660

文献信息

• Efficient Plastic Waste Recycling to Value‐Added Products by Integrated Biomass Processing
  作者：Kassem Beydoun、Jürgen Klankermayer

  DOI：10.1002/cssc.201902880

  日期：2020.2.7

  concepts directing towards a circular economy remain rather elusive. The present investigation focuses on the recycling of polyoxymethylene polymers, facilitated through combined catalytic processing of polymer waste and biomass‐derived diols. The integrated concept enables the production of value‐added cyclic acetals, which can flexibly function as solvents, fuel additives, pharmaceutical intermediates,

  聚合物材料的工业产量不断增加，但针对循环经济的可持续概念仍然相当难以捉摸。目前的研究重点是通过聚合物废物和生物质衍生二醇的联合催化加工促进聚甲醛聚合物的回收。该集成概念能够生产增值的环状缩醛，它可以灵活地用作溶剂、燃料添加剂、医药中间体，甚至用于聚合反应的单体材料。基于这种方法，可以设想对这些废料进行开环回收，其中聚合物废料的碳含量被有效地利用作为C1构建块，为聚甲醛聚合物循环经济中前所未有的可能性铺平了道路。
• 1,2,4-Triazolyl-Substituted Ketoenols
  申请人：Gienckle Wolfgang

  公开号：US20140302988A1

  公开（公告）日：2014-10-09

  The invention relates to novel compounds of the formula (I) in which X, Y and CKE have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides. The invention also relates to selective herbicidal compositions comprising, firstly, the 1,2,4-triazolyl-substituted ketoenols and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, 1,2,4-triazolyl-substituted ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as insecticides and/or acaricides and/or for preventing unwanted plant growth.

  该发明涉及公式（I）中的新化合物，其中X、Y和CKE具有上述给定的含义，涉及多种用于它们制备的过程和中间体，以及它们作为杀虫剂和/或除草剂的用途。该发明还涉及包括首先1,2,4-三唑基取代的酮烯醇和其次作物植物相容性改进化合物的选择性除草组合物。本发明还涉及通过向包含特别是1,2,4-三唑基取代的酮烯醇的作物保护组合物添加铵盐或磷盐以及可选的渗透剂，来增强作物保护组合物的作用，以及生产它们的过程以及它们在作物保护中作为杀虫剂和/或螨虫剂和/或用于防止不受欢迎的植物生长的应用。
• [EN] IMPROVED PROCESS FOR PRODUCING SIMVASTATIN<br/>[FR] PROCEDE AMELIORE DE PRODUCTION DE SIMVASTATINE
  申请人：JUBILANT ORGANOSYS LTD

  公开号：WO2005077928A1

  公开（公告）日：2005-08-25

  Disclosed herein is an industrially feasible process for producing HMG-CoA reductase inhibitor, simvastatin, via an improved acylation process using lovastatin ammonium salt as a starting material. The process comprising treating lovastatin ammonium salt with a base to obtain the compound of formula [III], lactonizing the compound of the formula [III] to obtain compound of formula [IV], selectively protecting the hydroxyl group of the compound of formula [IV] to obtain compound of formula [V], acylating the compound of formula [V] with dimethylbutyrylchloride using potassium halide in presence of a solvent to obtain compound of formula [VI], deprotecting compound of formula [VI] followed by hydrolysis to obtain simvastatin ammonium salt of formula [VII] which is lactonized to obtain simvastatin.

  本文披露了一种工业上可行的过程，通过改进的酰化过程利用洛伐他汀铵盐作为起始物质生产HMG-CoA还原酶抑制剂辛伐他汀。该过程包括将洛伐他汀铵盐与碱处理以获得式[III]的化合物，使式[III]的化合物内酯化以获得式[IV]的化合物，选择性保护式[IV]的羟基以获得式[V]的化合物，使用溶剂中的氯化二甲基丁酰基钾酰化式[V]的化合物以获得式[VI]的化合物，去保护式[VI]的化合物，然后水解以获得式[VII]的辛伐他汀铵盐，该铵盐内酯化以获得辛伐他汀。
• Sirtuin modulating compounds
  申请人：Nunes Joseph J.

  公开号：US20090099170A1

  公开（公告）日：2009-04-16

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新型的调节sirtuin的化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和紊乱，包括与衰老或压力相关的疾病或紊乱、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或紊乱。此外，还提供了包含sirtuin调节化合物与另一种治疗药物组合的组合物。
• Haloalkylmethyleneoxyphenyl-Substituted Ketoenols
  申请人：Bayer Intellectual Property GmbH

  公开号：US20140031577A1

  公开（公告）日：2014-01-30

  The invention relates to novel compounds of the formula (I), in which W, X, Y, Z and CKE are each as defined above, to several methods and intermediates for preparation thereof and to the use thereof as pesticides and/or herbicides. The invention also relates to selective herbicidal compositions which comprise firstly haloalkylmethyleneoxyphenyl-substituted ketoenols and secondly a compound which improves crop plant compatibility. The present invention further relates to the enhancement of the action of crop protection compositions comprising especially haloalkylmethyleneoxyphenyl-substituted ketoenols, by the addition of ammonium or phosphonium salts and optionally penetration enhancers, to the corresponding compositions, to methods for production thereof and to the use thereof in crop protection as insecticides and/or acaricides and/or for preventing undesired plant growth.

  本发明涉及公式（I）的新化合物，其中W、X、Y、Z和CKE的定义如上所述，以及制备它们的几种方法和中间体，以及将其用作杀虫剂和/或除草剂。本发明还涉及选择性除草剂组合物，其包括首先卤代烷基亚甲氧基苯基取代的酮醇，其次是一种改善作物植物兼容性的化合物。本发明还涉及通过添加铵盐或磷盐和可选的渗透增强剂到相应的组合物中，增强特别是卤代烷基亚甲氧基苯基取代的酮醇的作用的作物保护组合物的方法，以及其制备和将其用于作物保护作为杀虫剂和/或杀螨剂和/或防止不良植物生长。