6-(4-methyl-phenyl)-2-(1,2,4)-triazol-1-yl-methyl-2,4,5-trihydropyridazin-3-one | 1229037-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(4-methyl-phenyl)-2-(1,2,4)-triazol-1-yl-methyl-2,4,5-trihydropyridazin-3-one
• 英文别名: 6-(4-methylphenyl)-2-(2,3-dihydro-1H-1,2,4-triazol-1-ylmethyl)-4,5-dihydropyridazin-3(2H)-one；6-(4-Methylphenyl)-2-(1,2,4-triazol-1-ylmethyl)-4,5-dihydropyridazin-3-one
• CAS: 1229037-05-1
• 化学式: C₁₄H₁₅N₅O
• 分子量: 269.306
• InChiKey: VLROYGGPISFFND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(4-甲基苯甲酰)丙酸 在 hydrazine hydrate 作用下， 以 乙醇 为溶剂， 生成 6-(4-methyl-phenyl)-2-(1,2,4)-triazol-1-yl-methyl-2,4,5-trihydropyridazin-3-one
  参考文献：
  名称：

  Yusuf, Mohd; Alsaiari, Ahad Amer; Almehmadi, Mazen, Indian Journal of Heterocyclic Chemistry, 2022, vol. 32, # 3, p. 295 - 309

  摘要：

  DOI：

文献信息

• Synthesis, characterization and antihypertensive activity of pyridazinone derivatives
  作者：Anees A. Siddiqui、Ravinesh Mishra、Mohammad Shaharyar

  DOI：10.1016/j.ejmech.2010.02.003

  日期：2010.6

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.
• Yusuf, Mohd; Alsaiari, Ahad Amer; Almehmadi, Mazen, Indian Journal of Heterocyclic Chemistry, 2022, vol. 32, # 3, p. 295 - 309
  作者：Yusuf, Mohd、Alsaiari, Ahad Amer、Almehmadi, Mazen、Kamal, Mehnaz、Asif, Mohammad

  DOI：——

  日期：——