Tetrahydroharman-1,3-dicarbonsaeure | 18070-61-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: Tetrahydroharman-1,3-dicarbonsaeure
• 英文别名: 1,2,3,4-Tetrahydro-harman-1,3-dicarbonsaeure；1-methyl-2,3,4,9-tetrahydro-1H-β-carboline-1,3-dicarboxylic acid；1-methyl-1,2,3,4-tetrahydronorharman-1,3-dicarboxylic acid；(1xi,3S)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-1,3-dicarboxylic acid；1-methyl-2,3,4,9-tetrahydropyrido[3,4-b]indole-1,3-dicarboxylic acid
• CAS: 18070-61-6
• 化学式: C₁₄H₁₄N₂O₄
• 分子量: 274.276
• InChiKey: ZKGAKYZRRFOFGK-UHFFFAOYSA-N

物化性质

• 熔点：
  >192°C (dec.)
• 沸点：
  595.5±50.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  102
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Tetrahydroharman-1,3-dicarbonsaeure 以 甲醇 、 水 为溶剂， 反应 24.0h， 生成 harman
  参考文献：
  名称：

  Electrochemistry of natural products. 7. Oxidative decarboxylation of some tetrahydro-.beta.-carbolinecarboxylic acids

  摘要：

  DOI：

  10.1021/jo01298a045
• 作为产物：
  描述：

  DL-色氨酸 、 丙酮酸 以 硫酸 为溶剂， 反应 12.0h， 以62%的产率得到Tetrahydroharman-1,3-dicarbonsaeure
  参考文献：
  名称：

  Electrochemistry of natural products. 7. Oxidative decarboxylation of some tetrahydro-.beta.-carbolinecarboxylic acids

  摘要：

  DOI：

  10.1021/jo01298a045

文献信息

• METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS
  申请人：Almstead Neil

  公开号：US20120202763A1

  公开（公告）日：2012-08-09

  Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

  本文介绍了选择性抑制人类血管内皮生长因子（VEGF）病理性产生的化合物以及包含这些化合物的组合物。本文还介绍了抑制病毒复制或病毒RNA或DNA或病毒蛋白质产生的化合物以及包含这些化合物的组合物。同时，本文还介绍了使用这些化合物减少VEGF的方法以及使用这些化合物治疗癌症和非肿瘤性疾病的方法。本文还介绍了使用这些化合物抑制病毒复制或病毒RNA或DNA或病毒蛋白质产生的方法以及使用这些化合物治疗病毒感染的方法。这些化合物可以作为单一治疗剂或与一个或多个其他治疗剂联合使用，用于治疗需要这些治疗的人类。
• USE OF DERIVATIVES OF TETRAHYDRO-BETA-CARBOLINES AS ANTIMETASTATIC AGENTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0891187B1

  公开（公告）日：2002-01-30
• METHODS FOR TREATING NEUROFIBROMATOSIS
  申请人：Cao Liangxian

  公开号：US20120157401A1

  公开（公告）日：2012-06-21

  Methods for treating neurofibromatosis involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment.
• METHODS FOR TREATING KAPOSI SARCOMA
  申请人：Cao Liangxian

  公开号：US20120157400A1

  公开（公告）日：2012-06-21

  Methods for treating Kaposi's sarcoma involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment.
• METHODS FOR TREATING BRAIN TUMORS
  申请人：Cao Liangxian

  公开号：US20120157402A1

  公开（公告）日：2012-06-21

  Methods for treating brain tumors involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatment.