lupinic acid | 90978-66-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: lupinic acid
• 英文别名: 1-Lupininsaeure；(+/-)-Lupininsaeure；1-Epilupininsaeure；octahydro-quinolizine-1-carboxylic acid；Octahydro-chinolizin-1-carbonsaeure；1,2,3,4,5,6,7,8,9,9a-decahydroquinolizin-5-ium-1-carboxylate
• CAS: 90978-66-8
• 化学式: C₁₀H₁₇NO₂
• mdl: MFCD09991927
• 分子量: 183.25
• InChiKey: ZYQJGZAVMHNFNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  O-乙酰基-l-丝氨酸 、 玉米素 在 gallium(III) nitrate 、 磷酸吡哆醛 作用下， 以 水 为溶剂， 反应 2.0h， 以1.7%的产率得到lupinic acid
  参考文献：
  名称：

  Murakoshi, Isamu; Ikegami, Fumio; Yoneda, Yoshihiro, Chemical and pharmaceutical bulletin, 1986, vol. 34, # 4, p. 1473 - 1478

  摘要：

  DOI：

文献信息

• NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
  申请人：CHU Daniel

  公开号：US20090062268A1

  公开（公告）日：2009-03-05

  A compound having the structure set forth in Formula (I): wherein the variables Y, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Compounds described herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of such compounds and pharmaceutical compositions to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

  具有以下式（I）所示结构的化合物： 其中变量Y，R1，R2，R3，R4和R5如本文所定义。本文描述的化合物是聚(ADP-核糖)聚合酶活性的抑制剂。本文还描述了包括至少一种本文描述的化合物的药物组合物，以及利用这些化合物和药物组合物治疗通过抑制PARP活性而改善的疾病、疾病和症状。
• Novel photosensitive composition
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0304136A2

  公开（公告）日：1989-02-22

  A photosensitive composition comprising: (a) a polymer having recurring units represented by the formula wherein X is a (2 + m) valent C6-30 carbocyclic group or heterocyclic group ; Y is a (2 + n) valent C6-30 carbocyclic group or heterocyclic group ; A is -COOR* or -COO⊖R**⊕ wherein each of R* and R** is a group having a carbon-carbon double bond ; W is a group capable of reacting with the carbonyl group of A to form a ring on heating ; A and W are arranged in ortho- or peri- position to z ; m is 1 or 2 ; and n is 0, 1 or 2 , (b) 1 to 20 % by weight, based on the weight of polymer (a), of. a compound having a terminal ethylenically unsaturated group ; (c) 0.1 to 20 % by weight, based on the weight of polymer (a), of an oxime ester compound represented by the formula wherein each of R1, R2 and R3 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or a nitro group; R4 is a C7-11 aromatic acyl group, a C2-7 aliphatic acyl group, a C2-7 alkoxycarbonyl group, a C6-10 aromatic sulfonyl group or a C1-6 aliphatic sulfonyl group ; and R5 is a C1-6 alkyl group, a C1-6 alkoxy group, a C6-1o aromatic group or a C6-10 aryloxy group ; and (d) 0.01 to 10 % by weight, based on the weight of polymer (a), of a coumarin compound represented by the formula wherein R6 is a methyl group or an ethyl group ; and R7 is a C1-7 alkoxy group.

  一种光敏组合物，包括 (a) 具有由式表示的递归单元的聚合物 其中 X 是(2+m)价的 C6-30 碳环基团或杂环基团； Y 是(2+n)价的 C6-30 碳环基团或杂环基团； A 是 -COOR* 或 -COO⊖R**⊕ 其中每个 R* 和 R** 是具有碳碳双键的基团； W 是在加热时能与 A 的羰基反应形成环的基团； A 和 W 与 z 正交或近交排列； m 是 1 或 2 ；以及 n 为 0、1 或 2、 (b) 具有末端乙烯不饱和基团的化合物，以聚合物(a)的重量计，含量为 1%至 20%； (c) 具有末端乙烯不饱和基团的化合物，含量为 0.1%至 20%； (c) 以聚合物(a)的重量为基准，0.1%至 20%的肟酯化合物，其代表式为 其中 R1、R2 和 R3 各为氢原子、C1-6 烷基、C1-6 烷氧基或硝基；R4 为 C7-11 芳族酰基、C2-7 脂肪族酰基、C2-7 烷氧基羰基、C6-10 芳族磺酰基或 C1-6 脂肪族磺酰基；R5 为 C1-6 烷基、C1-6 烷氧基、C6-1o 芳族酰基或 C6-10 芳氧基；以及 R4 为 C7-11 芳族酰基、C2-7 脂肪族酰基、C2-7 烷氧基羰基、C6-10 芳族磺酰基或 C1-6 脂肪族磺酰基。 (d) 以聚合物(a)的重量为基准，0.01%至 10%的香豆素化合物，其代表式为 其中 R6 为甲基或乙基；R7 为 C1-7 烷氧基。
• CHARGE-TRANSPORTING VARNISH AND ORGANIC ELECTRO- LUMINESCENT DEVICES MADE BY USING THE SAME
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP1728827A1

  公开（公告）日：2006-12-06

  A charge-transporting varnish containing either a charge-transporting substance consisting of a charge-transporting oligoaniline or a charge-transporting organic material consisting of the charge-transporting substance and a charge-accepting dopant and at least one polymer selected from among polyimides and polyimide precursors; and charge-transporting thin films and organic EL devices, made by using the varnish. The varnish can give thin films which little suffer from defects and have high uniformity and flatness and excellent mechanical strengths, heat resistance, and transparency. In particular, the varnish realizes excellent EL characteristics such as low driving voltage, high emission efficiency, and long service life, when used in organic EL devices.

  一种电荷传输清漆，含有由电荷传输低聚苯胺组成的电荷传输物质或由电荷传输物质和电荷接受掺杂剂组成的电荷传输有机材料，以及至少一种从聚酰亚胺和聚酰亚胺前体中选出的聚合物；以及使用该清漆制成的电荷传输薄膜和有机电致发光器件。清漆可制成几乎没有缺陷、均匀度和平整度高、机械强度、耐热性和透明度优异的薄膜。特别是在用于有机 EL 器件时，清漆可实现低驱动电压、高发射效率和长使用寿命等优异的 EL 特性。
• Polyimide precursor solution, transfer/fixing member and process for producing polyimide seamless belt
  申请人：Katou Hirohisa

  公开号：US20050107526A1

  公开（公告）日：2005-05-19

  The object of the present invention is to provide a polyimide precursor solution having a good coating workability. Another object of the present invention is to provide transfer and fixing parts such as a polyimide seamless belt and the like produced from said polyimide precursor solution. Said polyimide precursor solution is produced by dissolving said polyimide precursor which is a homopolymer or copolymer of a polyamide acid in a solvent mixture of one or more kind(s) of solvent having a lower boiling point under 100° C., and one or more kind(s) of solvent having a higher boiling point of 100° C. or more, wherein said higher boiling point solvent (s) is (are) contained in said solvent mixture in an amount of 5 to 55% by weight.

  本发明的目的是提供一种具有良好涂层加工性的聚酰亚胺前体溶液。本发明的另一个目的是提供转移和固定部件，如用所述聚酰亚胺前体溶液生产的聚酰亚胺无缝带等。所述聚酰亚胺前体溶液是通过将所述聚酰亚胺前体（聚酰胺酸的均聚物或共聚物）溶解在由一种或多种沸点低于 100℃的低沸点溶剂和一种或多种沸点高于 100℃的高沸点溶剂组成的溶剂混合物中而制成的，其中所述高沸点溶剂在所述溶剂混合物中的含量为 5%至 55%（按重量计）。
• QUINOLIZIDINES WITH CALCIUM CHANNEL ANTAGONISTIC ACTIVITY
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0710237A1

  公开（公告）日：1996-05-08