morphine | 57-27-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: morphine
• 英文别名: 4,5-Epoxy-7,8-didehydro-17-methylmorphinan-3,6-diol；(4R,4aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
• CAS: 57-27-2；143-70-4；6912-73-8；16206-77-2；27067-73-8；65165-99-3；70982-47-7
• 化学式: C₁₇H₁₉NO₃
• 分子量: 285.343
• InChiKey: BQJCRHHNABKAKU-LVZGGSSKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险品标志：
  F,T
• 安全说明：
  S16,S36/37,S45,S7
• 危险类别码：
  R23/24/25,R39/23/24/25,R11
• 海关编码：
  2939110014
• 危险品运输编号：
  UN 1230 3/PG 2

文献信息

• PREPARATION AND UTILITY OF OPIOID ANALGESICS
  申请人：GANT Thomas G.

  公开号：US20080045558A1

  公开（公告）日：2008-02-21

  The present disclosure is directed to modulators of opiate- and/or NMDA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of pain, anxiety, neurodegeneration, drug dependence, coughing, muscular tension, and/or glaucoma and any other condition in which it is beneficial to modulate an opiate- and/or NMDA receptor.

  本公开涉及阿片和/或NMDA受体的调节剂及其药用盐和前药，其化学合成，以及利用这些化合物治疗和/或管理疼痛、焦虑、神经退行性疾病、药物依赖、咳嗽、肌肉紧张、和/或青光眼以及任何其他有益于调节阿片和/或NMDA受体的情况。
• Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts
  申请人：Wang Peter X.

  公开号：US20100035910A1

  公开（公告）日：2010-02-11

  An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.

  将三级吗啡类生物碱进行N-烷基化，形成相应的季铵盐型吗啡类生物碱衍生物的改进过程。
• ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS AND METHODS FOR REDUCING, PREVENTING OR TREATING PAIN AND INFLAMMATION
  申请人：ZANELLA John

  公开号：US20090263489A1

  公开（公告）日：2009-10-22

  Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

  提供了治疗急性疼痛和/或炎症的有效方法，可以持续一段时间。通过在目标部位或附近给予足够的磺胺嘧啶，可以缓解由不同来源引起的疼痛，包括但不限于脊椎盘突出（即坐骨神经痛）、脊柱侧弯、狭窄、盘源性背痛和关节疼痛以及手术后的疼痛。当在可生物降解聚合物中提供适当的配方时，这种缓解可以持续至少三天。在某些实施例中，缓解可以持续至少25天、至少50天、至少100天、至少135天或至少180天。
• DRUG DEPOTS FOR TREATMENT OF PAIN AND INFLAMMATION IN SINUS AND NASAL CAVITIES OR CARDIAC TISSUE
  申请人：WALSH Andrew J. Lowenthal

  公开号：US20100239632A1

  公开（公告）日：2010-09-23

  Effective treatments of pain and/or inflammation are provided. Through the administration of a biodegradable drug depot film, patch, strip or sponge being implantable at or near a cardiac tissue or within a nasal or sinus cavity, one can reduce, prevent or treat pain and/or inflammation.

  提供有效的疼痛和/或炎症治疗。通过在心脏组织附近或鼻腔或鼻窦内植入可生物降解的药物沉积膜、贴片、条或海绵，可以减轻、预防或治疗疼痛和/或炎症。
• METHOD OF TREATING A PATHOLOGICAL SYNDROME
  申请人：Epshtein Oleg Iliich

  公开号：US20160229914A1

  公开（公告）日：2016-08-11

  A method of treating disorder or condition that relates to intracellular signal transmission of a neurotransmitter, comprising administration of an homeopathically potentized form of antibodies to an antigen, which antigen is a molecule capable of effecting the intracellular signal transmission of a neuroreceptor, in particular dopamine or serotonin.

  一种治疗与神经递质的细胞内信号传递相关的疾病或症状的方法，包括给予一种高度稀释的抗原抗体制剂，该抗原是一种能够影响神经受体的细胞内信号传递的分子，特别是多巴胺或血清素。