2,2'-dihydroxy-3,3'-diacetyl-5,5'-dichlorodiphenylmethane | 60011-06-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-dihydroxy-3,3'-diacetyl-5,5'-dichlorodiphenylmethane
• 英文别名: bis-(3-acetyl-5-chloro-2-hydroxy-phenyl)-methane；Bis-(3-acetyl-5-chlor-2-hydroxy-phenyl)-methan；1,1'-[Methylenebis(5-chloro-2-hydroxy-3,1-phenylene)]bis-ethanone；1-[3-[(3-acetyl-5-chloro-2-hydroxyphenyl)methyl]-5-chloro-2-hydroxyphenyl]ethanone
• CAS: 60011-06-5
• 化学式: C₁₇H₁₄Cl₂O₄
• 分子量: 353.202
• InChiKey: RKQBHMHLZHAOLR-UHFFFAOYSA-N

物化性质

• 熔点：
  202–203°C
• 沸点：
  523.5±50.0 °C(Predicted)
• 密度：
  1.397±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2'-dihydroxy-3,3'-diacetyl-5,5'-dichlorodiphenylmethane 在 sodium hypoiodite 作用下， 以60%的产率得到3-[(3-羧基-5-氯-2-羟基苯基)甲基]-5-氯-2-羟基苯甲酸
  参考文献：
  名称：

  4,11,18,25-四氯[1 4 ] metacyclophane-7,14,21,28-tetroi的合成，叶绿素的结构类似物†

  摘要：

  描述了标题化合物的合成。所制备的某些化合物在体外表现出抗微生物活性。简要讨论了结构与活动的关系。

  DOI：

  10.1002/hlca.19820650411
• 作为产物：
  描述：

  双氯酚 在 三氯化铝 作用下， 反应 0.33h， 生成 2,2'-dihydroxy-3,3'-diacetyl-5,5'-dichlorodiphenylmethane
  参考文献：
  名称：

  多官能芳环体系的合成。磷脂，阿霉素，隐孢菌素和土霉素的结构类似物

  摘要：

  描述了标题化合物的合成。发现所制备的某些化合物在体外对多种病原微生物具有活性。

  DOI：

  10.1002/hlca.19810640224

文献信息

• Über Tetracyclin-ähnliche Komplexbildner
  作者：A. Moshfegh、S. Fallab、H. Erlenmeyer

  DOI：10.1002/hlca.19570400507

  日期：——

  Several benzophenone and biphenylmethane derivatives, structural analogues of terramycine, were prepared using the Baeyer, Friedel-Crafts, and Fries reactions.

  使用Baeyer，Friedel - Crafts和Fries反应制备了几种二苯甲酮和联苯甲烷衍生物，它们是土霉素的结构类似物。
• Preparation of mono- and binuclear complexes of copper(II), nickel(II), cobalt(II), iron(III) and vanadyl(V) with 2,2′-dihydroxy-3,3′-diacetyl-5,5′-dichlorodiphenylmethane
  作者：U. Russo、B. Zarli、P. Zanonato、M. Vidali

  DOI：10.1016/s0277-5387(00)81268-1

  日期：1991.1

  The synthesis of mononuclear complexes M(HL)2·nS [M = copper(II), nickel(II) and cobalt(II), S = solvent] and M′(HL)2OH·nS [M′ = iron(III) and vanadyl(V)] and of the binuclear complexes M2L2·nS [M = copper(II), nickel(II) and cobalt(II)] and Fe2L2(OH)2·H2O and (VO)2L2SO4·4H2O derived from 2,2′-dihydroxy-3,3′-diacetyl-5,5′-dichlorodiphenylmethane (H2L) is reported. Their coordination geometry is discussed

  单核络合物M（HL）2 · n S [M =铜（II），镍（II）和钴（II），S =溶剂]和M'（HL）2 OH· n S [M'=铁（III）和钒基（V）]以及双核络合物M 2 L 2 · n S [M =铜（II），镍（II）和钴（II）]和Fe 2 L 2（OH）2 · H 2 O和（VO）2 L 2 SO 4 ·4H 2 O衍生自2,2'-二羟基-3,3'-二乙酰-5,5'-二氯二苯甲烷（H 2L）被报告。根据理化数据讨论了它们的配位几何。室温下的磁性测量表明，双核螯合物中不存在金属离子之间的相互作用。铁（III）和钒（V）络合物用作氧化3,5-二叔丁基-1,2-二羟基苯（3,5-DBTC）的催化剂。通过氧化裂解，得到3,5-二叔丁基邻醌（3,5-DTBQ），3,5-二叔丁基-1-氧杂环庚-3,5-二烯-2,7-二酮（3,5-DTBODD），3,5-二叔丁基-5-羧甲基-2-呋喃酮（3
• Synthesis and characterisation of copper(II) complexes derived from methylene bridged bis(tridentate) ligands
  作者：P Kamatchi、M Kandaswamy

  DOI：10.1016/s0277-5387(97)00276-3

  日期：1998.1

  New methylene bridged bis(tridentate) binucleating ligands, bis[2-hydroxy-5-chloro(4-methylpiperazm-1-yl)methyl} phenyl]methane (L(1)H(2)), bis[2-hydroxy-3-(1-imino-N,N-dimethylaminopropyl)ethyl}-5-chlorophenyl]methane (L(2)H(2)) and bis[2-hydroxy-3-(1-imino-N,N-diethylaminopropyl)ethyl}-5-chlorophenyl] methane (L(3)H(2)) and their copper(II) complexes have been synthesised and reported. These complexes have been characterised by elemental analysis, electronic and ESR spectroscopy. The binuclearity of these complexes were confirmed by FAB mass spectroscopy. Electrochemical studies of the complexes suggested that the reduction processes are quasi-reversible single step two electron transfer Cu(II)Cu(II)/Cu(I)Cu(I) at negative potentials (-0.2 to -0.6 V). The magnetic moment mu(eff) (per Cu) for these complexes at 298 K are found in the range 1.71 to 1.83 B.M. Variable temperature magnetic susceptibility measurements revealed the absence of exchange coupling between Cu(II) centres. ESR spectra of these complexes at liquid nitrogen temperature (77 K) are similar to mononuclear copper(II) complex with nuclear spin 3/2. (C) 1998 Elsevier Science Ltd. All rights reserved.
• The Synthesis of 4,11,18,25-Tetrachloro [14]metacyclophane-7,14,21,28-tetroi, Structural Analogues of Phloroglucides
  作者：Ali A. Moshfegh、Rashid Badri、Massoud Hojjatie、Mehrangiz Kaviani、Basirat Naderi、Aboul H. Nazmi、Merrikh Ramezanian、Bizhan Roozpeikar、Gholam H. Haakimelahi

  DOI：10.1002/hlca.19820650411

  日期：1982.6.16

  The synthesis of the title compounds is described. Some of the compounds prepared exhibited antimicrobial activity in vitro. Structure-activity relationship is briefly discussed.

  描述了标题化合物的合成。所制备的某些化合物在体外表现出抗微生物活性。简要讨论了结构与活动的关系。
• The Synthesis of Polyfunctional Aromatic Ring Systems. Structural Analogues of Phloroglucides, Aranciamycin, Cryptosporin and Terramycin
  作者：Gholam Hosein Hakimelahi、Ali Akbar Moshfegh

  DOI：10.1002/hlca.19810640224

  日期：1981.3.18

  The synthesis of the title compounds is described. Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro.

  描述了标题化合物的合成。发现所制备的某些化合物在体外对多种病原微生物具有活性。