4-hexyl-pyrimidin-2-ylamine | 408314-56-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-hexyl-pyrimidin-2-ylamine
• 英文别名: 4-Hexylpyrimidin-2-amine
• CAS: 408314-56-7
• 化学式: C₁₀H₁₇N₃
• 分子量: 179.265
• InChiKey: LYFOVKUUNKQZTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hexyl-pyrimidin-2-ylamine 在 sodium hydroxide 作用下， 生成 sulfanilic acid-(4-hexyl-pyrimidin-2-ylamide)
  参考文献：
  名称：

  Sulfonamido Derivatives of Pyrimidines

  摘要：

  DOI：

  10.1021/ja01856a046
• 作为产物：
  描述：

  3-oxo-nonanoic acid propyl ester 在 palladium on activated charcoal 、 乙醇 、 三氯氧磷 作用下， 生成 4-hexyl-pyrimidin-2-ylamine
  参考文献：
  名称：

  Sulfonamido Derivatives of Pyrimidines

  摘要：

  DOI：

  10.1021/ja01856a046

文献信息

• Polyaminopyridines and method for producing same
  申请人：Kanbara Takaki

  公开号：US20060293503A1

  公开（公告）日：2006-12-28

  The present invention provides novel polyaminopyridines which are excellent in solubility in various solvents, and are preferably used in a polymer-type organic electroluminescent material, and a process for preparing the same. More particularly, the present invention provides polyaminopyridines having a repetition structural unit represented by the following general formula (1); and having a number average molecular weight in a range of 500 to 1000000.

  本发明提供了新型的聚氨基吡啶，其在各种溶剂中具有优异的溶解性，并且最好用于聚合物型有机电致发光材料，并提供了制备它们的过程。更具体地，本发明提供了具有以下一般式（1）所表示的重复结构单元的聚氨基吡啶，其具有500至1000000之间的数均分子量。
• Novel cyclic compound having pyrimidinylalkylthio group
  申请人：Tajima Hisashi

  公开号：US20110124646A1

  公开（公告）日：2011-05-26

  A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R 1 and R 2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R 3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A 1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A 2 represents an alkylene.

  通过给予化合物公式（1）或其盐的治疗有效量，治疗与血管生成相关的疾病的方法，其中环X代表R1和R2分别代表氢原子，烷基，芳基或芳香族杂环；R3代表氢原子，卤原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基，芳硫基，烷基亚磺酰基或非芳香族杂环；A1代表硫原子，亚磺酰基或磺酰基；A2代表烷基。
• Imidazo-heterocyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0120589A1

  公开（公告）日：1984-10-03

  New imidazo-heterocyclic compounds of the formula: wherein R' is hydrogen, lower alkyl or halogen, R2 is hydrogen, lower alkyl, halogen, aminomethyl optionally substituted with lower alkyl, or piperazin-1-yl-methyl optionally substituted with lower alkyl, R3 is a partially suturated heterocyclic group selected from benzothiazolinyl, benzoxazolinyl, benzimidazolinyl, 3,4-dihydro-2H-1, 4-benzothiazinyl, 3,4-dihydro-2H-1, 4-benzoxazinyl and 1,2,3,4-tetrahydroquinoxalinyl, which is substituted with oxo, thioxo, imino or lower alkylimino, and which may be substituted with lower alkyl optionally substituted with lower alkanoyloxy, lower alkoxycarbonyl, pyridyl or lower alkylamino; or an unsaturated heterocyclic group selected from benzoxazolyl and benzimidazolyl, which may be substituted with lower alkyl or pyridyl (lower) alkylthio, and Y is =N- or a group of the formula: in which R' is hydrogen, hydroxy, lower alkyl, lower alkoxy or ar(lower)alkoxy, and pharmaceutically acceptable saltsthereof, and processes for preparation thereof and pharmaceutical composition comprising the same. These derivatives and pharmaceutically acceptable salts thereof are useful as cardiotonic agents and antiulcer agents.

  式中的新咪唑三环化合物： 其中 R'是氢、低级烷基或卤素、 R2 是氢、低级烷基、卤素、任选被低级烷基取代的氨基甲基或任选被低级烷基取代的哌嗪-1-基甲基、 R3 是部分缝合的杂环基团，选自苯并噻唑啉基、苯并恶唑啉基、苯并咪唑啉基、3,4-二氢-2H-1, 4-苯并噻嗪基、3,4-二氢-2H-1, 4-苯并恶嗪基和 1,2,3,4-四氢喹喔啉基、被氧代、硫代、亚氨基或低级烷基亚氨基取代的低级烷基，以及可选被低级烷酰氧基、低级烷氧羰基、吡啶基或低级烷基氨基取代的低级烷基；或 不饱和杂环基团，选自苯并恶唑和苯并咪唑，可被低级烷基或吡啶（低级）烷硫基取代，以及 Y 是 =N- 或一个式中的基团： 其中 R' 是氢、羟基、低级烷基、低级烷氧基或 低级烷氧基、 及其药学上可接受的盐，以及其制备工艺和包含这些成分的药物组合物。 这些衍生物及其药学上可接受的盐可用作强心剂和抗溃疡剂。
• POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP1669390A1

  公开（公告）日：2006-06-14

  The present invention provides novel polyaminopyridines which are excellent in solubility in various solvents, and are preferably used in a polymer-type organic electroluminescent material, and a process for preparing the same. More particularly, the present invention provides polyaminopyridines having a repetition structural unit represented by the following general formula (1); and having a number average molecular weight in a range of 500 to 1000000.

  本发明提供了在各种溶剂中溶解性极佳的新型聚氨基吡啶，优选用于聚合物型有机电致发光材料，并提供了制备该材料的工艺。更具体地说，本发明提供了具有以下通式（1）所代表的重复结构单元的聚氨基吡啶； 且平均分子量在 500 至 1000000 之间。
• N¹-Sulfanilylamino-alkyl-pyrimidines
  作者：George W. Raiziss、Morris Freifelder

  DOI：10.1021/ja01262a034

  日期：1942.10