2-Aethyl-cyclohexylamin | 6850-36-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Aethyl-cyclohexylamin
• 英文别名: 2-Ethylcyclohexylamine；2-Ethylcyclohexan-1-amine
• CAS: 6850-36-8
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: QOPVVDFTPKWSFL-UHFFFAOYSA-N

物化性质

• 熔点：
  -15°C (estimate)
• 沸点：
  166.06°C (estimate)
• 密度：
  0.8744

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Aethyl-cyclohexylamin 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 乙醚 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  A Convenient Synthesis of 1-Alkyl-4,4-dimethyl-1,4,5,6-tetrahydropyridines¹

  摘要：

  An efficient two step synthesis of the title cyclic enamines (I) from 3,4-dihydro-4,4-dimethyl-2H-pyran-2-one (III) is described.

  DOI：

  10.1080/00397919308011120
• 作为产物：
  描述：

  吲哚 在 镍 、 萘烷 作用下， 225.0 ℃ 、2.53 MPa 条件下， 生成 2-Aethyl-cyclohexylamin
  参考文献：
  名称：

  Willstaetter; Seitz; v. Braun, Chemische Berichte, 1925, vol. 58, p. 385

  摘要：

  DOI：

文献信息

• Preparation of primary aromatic amines from cyclic alcohols and/or
  申请人：BASF Aktiengesellschaft

  公开号：US04355180A1

  公开（公告）日：1982-10-19

  Aromatic amines, in particular substituted amines, are obtained from corresponding alicyclic alcohols or ketones, in one step, by amination and dehydrogenation with ammonia in the presence of hydrogen and of a palladium catalyst which also contains zinc or cadmium.

  芳香胺，尤其是取代胺，可以通过一步反应从相应的环醇或酮中制得，该反应是氨在氢气和含锌或镉的钯催化剂存在下的氨化和脱氢过程。
• SULTAM DERIVATIVES
  申请人：Anderson Kevin W.

  公开号：US20110124686A1

  公开（公告）日：2011-05-26

  The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

  本发明涉及符合式1的化合物，具有细胞毒活性。这些化合物可用于治疗癌症。
• Pyrrolopyrazinyl Urea Kinase Inhibitors
  申请人：Bamberg Joe Timothy

  公开号：US20100144745A1

  公开（公告）日：2010-06-10

  The present invention relates to the use of novel pyrrolopyrazinyl urea derivatives of Formula I, wherein the variables R 1 , R 2 , R 3 , R 4 , and R 5 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用式I的新型吡咯吡嗪基脲衍生物，其中变量R1、R2、R3、R4和R5如本文所述定义，这些衍生物抑制JAK并可用于治疗自身免疫和炎症性疾病。
• SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS
  申请人：Bignan Gilles

  公开号：US20110294780A1

  公开（公告）日：2011-12-01

  The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

  本发明涉及式(I)的化合物，制备这些化合物的方法，组合物，中间体及其衍生物，并用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿关节炎，感染性关节炎，儿童关节炎，银屑病性关节炎，反应性关节炎），与骨相关的疾病（包括与骨形成有关的疾病），乳腺癌（包括对抗雌激素治疗无效的癌症），心血管疾病，软骨相关疾病（如软骨损伤/丧失，软骨退化以及与软骨形成有关的疾病），软骨发育不良，软骨肉瘤，慢性腰部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺疾病，糖尿病，能量稳态紊乱，痛风，假性痛风，脂质紊乱，代谢综合征，多发性骨髓瘤，肥胖，骨关节炎，遗传性骨发育不全，骨溶解性骨转移，软骨软化症，骨质疏松症，帕金森病，牙周病，多肌痛风，Reiter综合征，重复性应激损伤，高血糖，血糖水平升高和胰岛素抵抗等病症的方法。
• Preparation of aromatic amines
  申请人：BASF Aktiengesellschaft

  公开号：US04429155A1

  公开（公告）日：1984-01-31

  Aromatic amines (anilines) are obtained directly or via the corresponding cycloaliphatic amines by an aminating/hydrogenating reaction of phenols with ammonia and hydrogen over a supported palladium catalyst which also contains elements from group 1b, 2b or 7b of the periodic table as well as iron, cobalt or nickel, as such or in the form of their compounds, and, preferably, an inorganic base, said catalysts also having dehydrogenating properties.

  芳香胺（苯胺）是通过在支撑钯催化剂上，利用苯酚与氨和氢气进行氨化/氢化反应直接或通过相应的环脂肪胺获得的，该催化剂还包含周期表1b、2b或7b族元素以及铁、钴或镍，或者以它们的化合物形式存在，并且最好还包含无机碱，这些催化剂还具有脱氢性能。