2-Chloroamphetamine hydrochloride | 35334-29-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloroamphetamine hydrochloride
• 英文别名: 1-(2-chlorophenyl)propan-2-amine;hydrochloride
• CAS: 35334-29-3
• 化学式: C9H13Cl2N
• mdl: MFCD11811762
• 分子量: 206.11
• InChiKey: OMZVWFGRVWIEKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA PRÉPARATION DE CONJUGUÉS D'AMPHÉTAMINE ET DE SELS DE CEUX-CI
  申请人：CAMBREX CHARLES CITY INC

  公开号：WO2010148305A1

  公开（公告）日：2010-12-23

  The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.

  这项发明提供了制备苯丙胺共轭物的方法和组合物，例如利斯达氯安非他明、同型精氨酸-D-苯丙胺及其盐。在一个实施例中，该发明提供了从氯苯丙胺中间体制备苯丙胺共轭物的方法。
• METHOD OF MAKING AMPHETAMINE
  申请人：Buenger Greg

  公开号：US20090292143A1

  公开（公告）日：2009-11-26

  A method in which a crude chlorinated product of a phenylpropanolamine, preferably prepared by reacting thionyl chloride with the phenylpropanolamine, is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.

  一种方法，通过将苯丙醇胺与亚砜氯反应制备粗氯化产物，然后通过将粗产品的水溶液与活性炭接触来纯化。经活性炭处理的苯丙醇胺粗氯化产物的溶液被催化氢化成相应的苯丙胺衍生物。
• PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES
  申请人：NORAMCO, INC.

  公开号：US20160376618A1

  公开（公告）日：2016-12-29

  The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

  本发明涉及制备利斯达洛非甲胺及相关衍生物的过程，其中该过程包括与外消旋或旋光异构富集的苯丙胺偶联，并且所得产物有优势地在所需立体异构体方面富集旋光异构体或二对映异构体。
• [EN] 1-(3-QUINOLYL)-3,4-DIHYDROISOQUINOLINE DERIVATIVES AS FUNGICIDES FOR COMBATING SPECIFIC PHYTOPATHOGENS<br/>[FR] DÉRIVÉS DE 1-(3-QUINOLYL)-3,4-DIHYDROISOQUINOLÉINE UTILISÉS EN TANT QUE FONGICIDES POUR LUTTER CONTRE DES PHYTOPATHOGÈNES SPÉCIFIQUES
  申请人：SYNGENTA CROP PROTECTION AG

  公开号：WO2021074309A1

  公开（公告）日：2021-04-22

  1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

  1-(3-喹啉基)-3,4-二氢异喹啉衍生物的化学式(I)，以及一种用于对抗、预防或控制植物病原体Mycosphaerella graminicola (小麦丝孢菌), Fusarium culmorum, Gibberella zeae (玉米赤霉菌) 和 Monographella nivalis (雪腐病菌) 的方法，包括向植物病原体、植物病原体的生长部位，或易受植物病原体侵袭的植物，或其繁殖材料施加具有杀菌效果的1-(3-喹啉基)-3,4-二氢异喹啉衍生物的有效量。本描述披露了示例化合物的合成、配方示例、相关生物数据（在植物上喷洒后对Mycosphaerella graminicola (小麦丝孢菌), Fusarium culmorum, Gibberella zeae (玉米赤霉菌) 和 Monographella nivalis (雪腐病菌) 的抗真菌活性），以及与三种先前技术的化合物的比较数据（例如第52至85页；配方示例；示例A1至A3；表E；化合物E.01至E.187；生物学示例）。示例化合物包括：5-溴-1-(8-氟-3-喹啉基)螺[4H-异喹啉-3,1'-环丙烷]（示例A1）、5-溴-1-(8-氟-3-喹啉基)-3,3-二甲基-4H-异喹啉（示例A2）、1-(8-氟-3-喹啉基)-3,3-二甲基-4H-异喹啉-5-碳腈（示例A3）。
• [EN] PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LISDEXAMFÉTAMINE ET DE DÉRIVÉS ASSOCIÉS
  申请人：NORAMCO INC

  公开号：WO2017003721A1

  公开（公告）日：2017-01-05

  The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

  本发明涉及制备利斯达克赛非及其相关衍生物的过程，其中该过程包括与外消旋或对映富集的苯丙胺偶联，所得产物在所需立体异构体方面具有有利的对映异构体或二对映异构体富集。