4-Hydroxy-3-methoxy-1--benzol | 100520-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-Hydroxy-3-methoxy-1--benzol
• 英文别名: 4-Hydroxy-3-methoxy-1-(diaethylmercapto-methyl)-benzol；Bis(ethylthio)methyl-2-methoxyphenol；4-[bis(ethylsulfanyl)methyl]-2-methoxyphenol
• CAS: 100520-59-0
• 化学式: C₁₂H₁₈O₂S₂
• 分子量: 258.406
• InChiKey: JJJCKQVAQUKTLI-UHFFFAOYSA-N

物化性质

• 沸点：
  373.2±42.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-3-methoxy-1--benzol 在 bismuth(lll) trifluoromethanesulfonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.25h， 以80%的产率得到香草醛
  参考文献：
  名称：

  使用三氟甲基磺酸铋有效催化脱硫基缩醛的保护反应：吡咯并[2,1- c ] [1,4]苯并二氮杂synthesis的合成

  摘要：

  通过使用三氟甲磺酸铋已经实现了对硫缩醛的简单有效的脱保护。该方法已有效地用于制备结合DNA的吡咯并[2,1- c ] [1,4]苯并二氮杂及其二聚体。

  DOI：

  10.1016/s0040-4039(03)00437-4
• 作为产物：
  描述：

  香草醛 、 乙硫醇 在 sodium hydrogen sulfate 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以93%的产率得到4-Hydroxy-3-methoxy-1--benzol
  参考文献：
  名称：

  羰基化合物的简单、温和和高效的硫代缩醛化和转硫缩醛化以及硫代缩醛的脱保护：硫醇在硫代缩醛化选择性中的独特作用

  摘要：

  二氧化硅负载的硫酸氢钠 (NaHSO 4 .SiO 2 ) 已被用于在室温下在 CH 2 Cl 2 中对羰基化合物进行有效的硫缩醛化和转硫缩醛化。硫缩醛化的选择性取决于用于转化的硫醇。还发现相同的催化剂在室温下在 CH 2 Cl 2 -H 2 O 中对硫缩醛的脱保护有效。

  DOI：

  10.1055/s-2004-834934

文献信息

• A Simple and Efficient Heterogeneous Procedure for Thioacetalization of Aldehydes and Ketones
  作者：Mohammed Hashmat Ali、Maria Goretti Gomes

  DOI：10.1055/s-2005-865303

  日期：——

  A new procedure for the protection of aldehydes and ketones as thioacetals promoted by catalytic amount of p-toluene-sulfonic acid and silica gel has been developed. This procedure offers versatility, short reaction time,excellent yield, good selectivity, and flexibility in terms of choice of solvent that can be utilized in this reaction. The procedure is easy to carry out and does not require aqueous

  已经开发了一种通过催化量的对甲苯磺酸和硅胶促进作为硫缩醛保护醛和酮的新方法。该程序提供了多功能性、反应时间短、产率高、选择性好以及在选择可用于该反应的溶剂方面的灵活性。该程序易于执行，不需要水处理。在大多数情况下，简单的过滤然后去除溶剂会产生纯产品。
• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• γ-AApeptides with potent and broad-spectrum antimicrobial activity
  申请人：Cai Jianfeng

  公开号：US10144764B2

  公开（公告）日：2018-12-04

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一类名为γ-AA肽的新型抗菌剂。本发明提供了各种类型的 γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂化γ-AA肽。本发明中的γ-AA 肽具有抗菌活性，同时稳定无毒。γ-AA肽似乎也不会导致被处理微生物产生抗药性。因此，所公开的γ-AA 肽可用于治疗与病原微生物有关的各种病症。
• Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
  申请人：Cai Jianfeng

  公开号：US10308686B2

  公开（公告）日：2019-06-04

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一类名为γ-AA肽的新型抗菌剂。本发明提供了各种类型的 γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂化γ-AA肽。本发明中的γ-AA 肽具有抗菌活性，同时稳定无毒。γ-AA肽似乎也不会导致被处理微生物产生抗药性。因此，所公开的γ-AA 肽可用于治疗与病原微生物有关的各种病症。
• Sustained-release injectable formulation
  申请人：Friedman Michael

  公开号：US11052043B2

  公开（公告）日：2021-07-06

  A composition which comprises a biologically active agent and a polymer that exhibits a reverse thermal gelation at a physiological temperature, in a carrier, and in which the active agent is in an undissolved form is disclosed herein. Further disclosed herein are methods utilizing the compositions for treating subjects, including non-human subjects, as well as kits for preparing and using a composition. The composition is preferably a sustained release formulation, and is particularly useful for treating animals, where single-dose treatment is desired.

  本文公开了一种组合物，该组合物由生物活性剂和在生理温度下呈现反向热凝胶化的聚合物组成，其载体中的活性剂为未溶解形式。本文进一步公开了利用组合物治疗受试者（包括非人类受试者）的方法，以及制备和使用组合物的试剂盒。组合物最好是缓释制剂，尤其适用于治疗动物，因为动物需要单剂量治疗。