norethisterone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: norethisterone
• 英文别名: 17α-Ethinyl-19-nor-testosteron；Norethisteron；17α-Aethinyl-19-nor-testosteron；Norethindron；(13S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₀H₂₆O₂
• 分子量: 298.425
• InChiKey: VIKNJXKGJWUCNN-RZXUBOOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[18F]fluoroethylazide 、 norethisterone 在 copper(ll) sulfate pentahydrate 、 bathophenanthrolinedisulfonic acid 、 sodium ascorbate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以95.3%的产率得到
  参考文献：
  名称：

  Facile purification and click labeling with 2-[18F]fluoroethyl azide using solid phase extraction cartridges

  摘要：

  A facile method was developed to purify 2-[F-18] fluoroethyl azide ([F-18]FEA) using a C18 cartridge and an Oasis (R) HLB cartridge in series, in which [18FWEA was exclusively trapped on the HLB cartridge. [F-18]]FEA can be eluted for reactions in solution; alternatively click labeling can be carried out on the HLB cartridge itself by loading an alkyne substrate and copper (I) catalyst dissolved in DMF onto the cartridge. This solid phase extraction methodology for purification and click labeling with [F-18]FEA, either in solution or on the cartridge, is safe, simple, reproducible in high yield, and compatible with automated synthesis of 'F-labeled PET tracers. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.126

文献信息

• A mild protocol for efficient preparation of functional molecules containing triazole
  作者：Jing Leng、Jie Xu、Yanan Li、Shi-Meng Wang、Hua-Li Qin

  DOI：10.1039/d4ra01271b

  日期：——

  The construction of a class of novel triazole molecules containing sulfonyl fluoride functionalities was achieved through Cu-catalyzed click chemistry in good to excellent yields. The sulfonyl fluoride moieties were cleaved completely under base conditions to produce N-unsubstituted triazoles quantitatively, which provides a strategy to combine SuFEx click chemistry with Cu-catalyzed click chemistry

  通过铜催化的点击化学，以良好至优异的收率构建了一类含有磺酰氟官能团的新型三唑分子。磺酰氟部分在碱性条件下完全裂解，定量产生N-未取代的三唑，这提供了将SuFEx点击化学与Cu催化点击化学巧妙结合的策略。