2-(6-chloro-4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(cyclohexylideneamino)acetamide | 211562-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(6-chloro-4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(cyclohexylideneamino)acetamide
• CAS: 211562-87-7
• 化学式: C₂₂H₂₁ClN₄O₂S
• 分子量: 440.953
• InChiKey: LNBRAFBFAMSVHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  99.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  硫代乳酸 、 2-(6-chloro-4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(cyclohexylideneamino)acetamide 以 苯 为溶剂， 反应 48.0h， 以77%的产率得到2-(6-chloro-4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)acetamide
  参考文献：
  名称：

  New cyclohexylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of 3-phenyl-4(3H)-quinazolinones

  摘要：

  In this study, the synthesis of (3-phenyl-4(3H) -quinazolinon-2-yl) mercaptoacetic acid cyclohexylidenehydrazides and 4-[(3-phenyl-4(3H) -quinazolinon-2-yl) mercaptoacetylamino] -4-aza-1-thiaspiro [4.5] decan-3-ones and the results of the study on their antifungal activity are reported. Most of the tested compounds were found to be active against Microsporum gypseum NCPF-580, Microsporum canis, Tricophyton mentagrophytes NCPF-375 var. erinacei and Tricophyton rubrum at 25 mu g/ml. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00032-9
• 作为产物：
  描述：

  环己酮 、 2-((6-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide 以 乙醇 为溶剂， 反应 4.0h， 以92%的产率得到2-(6-chloro-4-oxo-3-phenylquinazolin-2-yl)sulfanyl-N-(cyclohexylideneamino)acetamide
  参考文献：
  名称：

  New cyclohexylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of 3-phenyl-4(3H)-quinazolinones

  摘要：

  In this study, the synthesis of (3-phenyl-4(3H) -quinazolinon-2-yl) mercaptoacetic acid cyclohexylidenehydrazides and 4-[(3-phenyl-4(3H) -quinazolinon-2-yl) mercaptoacetylamino] -4-aza-1-thiaspiro [4.5] decan-3-ones and the results of the study on their antifungal activity are reported. Most of the tested compounds were found to be active against Microsporum gypseum NCPF-580, Microsporum canis, Tricophyton mentagrophytes NCPF-375 var. erinacei and Tricophyton rubrum at 25 mu g/ml. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00032-9