amlodipine hydrobromide | 246852-09-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: amlodipine hydrobromide
• 英文别名: 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;hydrobromide
• CAS: 246852-09-5
• 化学式: BrH*C₂₀H₂₅ClN₂O₅
• 分子量: 489.794
• InChiKey: RVCDRXDQZIUQJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  99.9
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  amlodipine hydrobromide 、 1-{[19-氨基-7-(2-氨基-2-羰基乙基)-10-(3-氨基-3-羰基丙基)-16-(4-乙基苯甲基)-13-(1-甲基丙基)-6,9,12,15,18-五羰基-1,2-二硫杂-5,8,11,14,17-五氮杂环二十碳烷-4-基]羰基}脯氨酰亮氨酰甘氨酸酰胺 以 水 为溶剂， 反应 0.33h， 生成 苯磺酸氨氯地平
  参考文献：
  名称：

  A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE

  摘要：

  公开号：

  EP0993447B1

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE<br/>[FR] PROCEDE DE PREPARATION D'AMLOPIDINE BENZENESULFONATE
  申请人：ADAMED SP. Z O.O.

  公开号：WO1999052873A1

  公开（公告）日：1999-10-21

  (EN) A process for the preparation of amlodipine benzenesulphonate is disclosed, wherein a salt of amlodipine with an inorganic or organic acid is reacted with alkali metal benzenesulphonate in an aqueous medium or in a mixture water-alcohol C1-C2. Amlodipine benzenesulphonate is used for the preparation of a medicament having calcium channel blocking activity, useful in the treatment of the coronary disease and arterial hypertension.(FR) L'invention concerne un procédé de préparation d'amlopidine benzènesulfonate dans lequel on fait réagir un sel d'amlopidine avec un acide organique ou inorganique et un benzènesulfonate de métal alcalin dans un milieu aqueux ou dans un mélange eau-alcool C1-C2. L'amlopidine benzènesulfonate est utilisé pour la préparation d'un médicament présentant une activité de blocage des voies calciques, lequel médicament s'avère utile dans le traitement des maladies coronariennes et de l'hypertension artérielle.
• [EN] (S)-AMLODIPINE MALATE<br/>[FR] (S)-AMLODIPINE MALATE
  申请人：SEPRACOR INC

  公开号：WO2005089353A2

  公开（公告）日：2005-09-29

  One aspect of the present invention relates to optically pur (S)-amlodipine malate. Another aspect of the present invention relates to (rac)-amlopidine malate. In a preferred embodiment, compound is optically pure (S)-amlodipine L-malate. Another aspect of the present invention relates to a pharmaceutical composition comprising optically pure (S)-amlodipine malate. Another aspect of the present invention relates to a method of preparing optically pure (S)-amlodipine malate, comprising admixing optically pure (S)-amlodipine with malic acid. Another aspect of the present invention relates to the various polymorphic and solvated forms of optically pure (S)-amlodipine malate. In another prefered embodiment the invention relates to polymorphic and solvated forms A-G. The present invention also relates to a method of preparing optically pure (S)-amlodipine malate, comprising combining a salt of optically pure (S)-amlodipine with a malate salt to give optically pure (S)-amlodipine malate. In a preferred embodiment, the malate salt is an optically pure L-malate salt.
• A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE
  申请人：Adamed SP. Z O.O.

  公开号：EP0993447B1

  公开（公告）日：2005-08-17