DL-4-Benzyl-2,4-dimethyl-2-oxazolin-5-on | 14715-67-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DL-4-Benzyl-2,4-dimethyl-2-oxazolin-5-on
• 英文别名: 4-benzyl-2,4-dimethyl-4H-oxazol-5-one；4-Benzyl-2,4-dimethyl-1,3-oxazol-5-one
• CAS: 14715-67-4
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: SGPCDAPPCJLKBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  DL-4-Benzyl-2,4-dimethyl-2-oxazolin-5-on 在 氢氧化钾 作用下， 生成 (+)-N-Acetyl-(R)-α-methylphenylalanin
  参考文献：
  名称：

  Terashima,S. et al., Chemical and pharmaceutical bulletin, 1966, vol. 14, p. 1138 - 1143

  摘要：

  DOI：
• 作为产物：
  描述：

  N-Acetyl-α-methylphenylalanin 在 乙酸酐 作用下， 反应 6.0h， 生成 DL-4-Benzyl-2,4-dimethyl-2-oxazolin-5-on
  参考文献：
  名称：

  Terashima,S. et al., Chemical and pharmaceutical bulletin, 1966, vol. 14, p. 1138 - 1143

  摘要：

  DOI：

文献信息

• Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
  申请人：Rhone-Poulenc, Inc.

  公开号：US06344564B1

  公开（公告）日：2002-02-05

  Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones, processes for their preparation, fungicidal compositions containing them, and methods of using them to treat or prevent fungal disease in crops.

  杀真菌剂2-咪唑啉-5-酮和2-咪唑啉-5-硫酮，它们的制备方法，含有它们的杀真菌组合物，以及使用它们来治疗或预防作物真菌病的方法。
• Peptidylaminodiols
  申请人：ABBOTT LABORATORIES

  公开号：EP0189203A2

  公开（公告）日：1986-07-30

  The invention relates to renin inhibiting compounds of the formula: wherein R10 is A is hydrogen or an N-protecting group; w is 0 or 1; B is hydrogen, hydroxy, NH, N-alkyl, loweralkyl or arylalkyl; with the proviso that when w is 1, B is NH and when w is 0, B is hydrogen, hydroxy, loweralkyl or arylalkyl; R1is loweralkyl or lipophilic or aromatic or hydrophilic amino acid side chains; m is 1-3; n is 1-3; p is 1-3; q is 1-3; s is 1-3; t is 0-2; R2 is hydrogen or loweralkyl; R3 and R4 are independently selected from loweralkyl, lipophilic or aromatic amino acid side chains; R5 and R7 are independently selected from hydrogen or loweralkyl; and R6 is hydrogen, loweralkyl, vinyl, arylalkyl or wherein R8 is hydrogen or loweralkyl, X is O, NH or S and R9 is hydrogen, loweralkyl or alkanoyl or XR9 together can be loweralkylsulfonyl, N3 or Cl.

  本发明涉及式中的肾素抑制化合物： 其中 R10 是 A是氢或N-保护基；w是0或1；B是氢、羟基、NH、N-烷基、低级烷基或芳基烷基；但当w是1时，B是NH，当w是0时，B是氢、羟基、低级烷基或芳基烷基；R1是低级烷基或亲油性或芳香性或亲水性氨基酸侧链；m是1-3；n是1-3；p是1-3；q是1-3；s是1-3；t是0-2；R2是氢或低级烷基；R3 和 R4 独立选自低烷基、亲油或芳香族氨基酸侧链；R5 和 R7 独立选自氢或低烷基；R6 是氢、低烷基、乙烯基、芳烷基或其中 R8 是氢或低烷基，X 是 O、NH 或 S，R9 是氢、低烷基或烷酰基或 XR9 合在一起可以是低烷基磺酰基、N3 或 Cl。
• PROCESS FOR THE PREPARATION OF AMIDES
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1092705A1

  公开（公告）日：2001-04-18

  The present invention aims at providing important intermediates used in production of a phenylalkanoic acid amide compound showing an excellent fungicidal effect; and novel and simple processes for producing such an intermediate or a raw material compound used in production of the intermediate. The present invention relates to a process for producing an amide compound represented by the following general formula [wherein R is an alkyl group, a cycloalkyl group, a haloalkyl group, an aryl group, a substituted aryl group, an arylalkyl group, a substituted arylalkyl group, an (aryl)(alkoxy)alkyl group or a (substituted aryl)(alkoxy)alkyl group; R1 and R2 are each independently an alkyl group, a cycloalkyl group, a haloalkyl group, an arylalkyl group, a substituted arylalkyl group, an aryl group, a substituted aryl group or a hydrogen atom, and may bond with each other to form a ring together with the carbon atom with which they bond; and R3 is an alkyl group, a cycloalkyl group, a haloalkyl group, an arylalkyl group, a substituted arylalkyl group, an aryl group, a substituted aryl group or a hydrogen atom], which process comprises reacting a nitrile compound represented by the following general formula (wherein R, R1 and R2 each have the same definition as given above) with an acid to give rise to intramolecular ring closure to obtain an oxazolinone compound represented by the following general formula (wherein R, R1 and R2 each have the same definition as given above), and reacting the oxazolinone compound with a carboxy compound represented by the following general formula (wherein Y is a hydrogen atom, a carboxyl group or a salt of the carboxyl group; and R3 has the same definition as given above) in the presence of a base.

  本发明旨在提供用于生产具有优异杀菌效果的苯烷酸酰胺化合物的重要中间体；以及生产这种中间体或用于生产这种中间体的原料化合物的新颖而简单的工艺。 本发明涉及一种生产由以下通式表示的酰胺化合物的工艺 [其中 R 是烷基、环烷基、卤代烷基、芳基、取代的芳基、芳烷基、取代的芳烷基、 （芳基）（烷氧基）烷基或（取代的芳基）（烷氧基）烷基；R1 和 R2 各自独立地为烷基、环烷基、卤代烷基、芳烷基、取代芳烷基、芳基、取代芳基或氢原子，并可相互键合，与键合的碳原子一起形成环；和 R3 是烷基、环烷基、卤代烷基、芳烷基、取代芳烷基、芳基、取代芳基或氢原子]，该工艺包括使以下通式表示的腈化合物反应 (其中 R、R1 和 R2 的定义同上）与酸反应，产生分子内环闭合，得到下式通式所代表的噁唑啉酮化合物 (其中 R、R1 和 R2 的定义同上），并将该噁唑啉酮化合物与下式通式所代表的羧基化合物反应 (其中 Y 为氢原子、羧基或羧基盐；R3 的定义与上述相同）在碱存在下反应。
• Formaggio, Fernando; Crisma, Marco; Valle, Giovanni, Journal of the Chemical Society. Perkin transactions II, 1992, # 11, p. 1945 - 1950
  作者：Formaggio, Fernando、Crisma, Marco、Valle, Giovanni、Toniolo, Claudio、Boesten, Wilhelmus H. J.、et al.

  DOI：——

  日期：——
• US4680284A
  申请人：——

  公开号：US4680284A

  公开（公告）日：1987-07-14