bis(2,4-difluorophenyl) carbonate | 355423-39-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2,4-difluorophenyl) carbonate
• CAS: 355423-39-1
• 化学式: C₁₃H₆F₄O₃
• 分子量: 286.182
• InChiKey: URZKFDMKDWGAGV-UHFFFAOYSA-N

物化性质

• 沸点：
  300.1±42.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  bis(2,4-difluorophenyl) carbonate 在 硫酸 、 溴 、 氯 作用下， 反应 2.0h， 以81%的产率得到bis(5-bromo-2,4-difluorophenyl) carbonate
  参考文献：
  名称：

  WO2006/76246

  摘要：

  公开号：
• 作为产物：
  描述：

  光气 、 2,4-二氟苯酚 在 吡啶 作用下， 以 甲苯 为溶剂， 以94%的产率得到bis(2,4-difluorophenyl) carbonate
  参考文献：
  名称：

  WO2006/76246

  摘要：

  公开号：

文献信息

• [EN] CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS<br/>[FR] CERTAINES ENTITÉS CHIMIQUES, COMPOSITIONS ET PROCÉDÉS
  申请人：NEUPHARMA INC

  公开号：WO2013049701A1

  公开（公告）日：2013-04-04

  Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described. Specifically quinoxaline derivatives of Formula I and their use in modulating the activity of Braf and/or mutant Braf kinase to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism are disclosed. Also disclosed are methods of treating cancer associated with Braf and/or mutant Braf kinase activity in a subject, comprising administering the compounds of Formula I.

  本文介绍了一些激酶抑制剂的化学实体、药物组合物及治疗癌症的方法。具体地，揭示了I式喹喔啉衍生物及其在调节和调控Braf和/或突变Braf激酶活性以调节和调控异常或不适当的细胞增殖、分化或代谢方面的应用。还揭示了一种治疗与Braf和/或突变Braf激酶活性相关的癌症的方法，包括给予I式化合物。
• POLYHYDRIC PHENOL COMPOUND AND METHOD OF PRODUCING SAME
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20190210947A1

  公开（公告）日：2019-07-11

  The present invention provides a polyhydric phenol compound which has an excellent alkali resistance and which does not cause a deterioration in color even when used as a resin raw material or a color developer. The polyhydric phenol compound includes: a bisphenol compound (A) represented by the following Formula (1) and a trisphenol compound (B) represented by the following Formula (2): [wherein R 1 represents a monovalent aliphatic hydrocarbon group having from 6 to 24 carbon atoms; each of R 2 , R 3 , R 4 , R 5 and R 6 represents a monovalent hydrocarbon group having from 1 to 15 carbon atoms; and each of a, b, c, d and e represents an integer from 0 to 4]; wherein the trisphenol compound (B) is contained in an amount, in terms of absorption intensity ratio at 254 nm, of less than 1.6% by area with respect to the amount of the bisphenol compound (A).

  本发明提供了一种聚羟基酚化合物，具有优异的耐碱性能，并且即使用作树脂原料或颜料开发剂也不会导致颜色恶化。该聚羟基酚化合物包括：由以下公式（1）表示的双酚化合物（A）和由以下公式（2）表示的三酚化合物（B）：[其中R1表示具有6至24个碳原子的单价脂肪烃基；R2、R3、R4、R5和R6中的每一个表示具有1至15个碳原子的单价烃基；a、b、c、d和e中的每一个表示0至4的整数]；其中，以吸收强度比值（在254 nm处）计算，三酚化合物（B）的含量在面积上小于双酚化合物（A）的含量的1.6％。
• Phenylglycinamide derivatives useful as anticoagulants
  申请人：Zhang Xiaojun

  公开号：US20060166997A1

  公开（公告）日：2006-07-27

  The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

  本发明一般涉及抑制丝氨酸蛋白酶的苯基甘氨酰衍生物。具体而言，本发明涉及新型苯基甘氨酰衍生物及其类似物，其可用作凝血级联反应的丝氨酸蛋白酶酶的选择性抑制剂；例如凝血酶、第VIIa因子、第Xa因子、第XIa因子、第IXa因子和/或血浆激肽。特别是，它涉及到的化合物是第VIIa因子的抑制剂。本发明还涉及包含这些化合物的制药组合物及其使用方法。
• Process for producing polycarbonate compositions
  申请人：SABIC Innovative Plastics IP B.V.

  公开号：EP2730618A1

  公开（公告）日：2014-05-14

  A method for manufacturing a polycarbonate composition having improved transparency can comprise reacting an aromatic dihydroxy compound and a diaryl carbonate under melt polymerization conditions to provide a polycarbonate; and contacting the polycarbonate with a polydiorgano siloxane having a kinematic viscosity of less than 20 mm2/sec at 25°C as determined in accordance with ASTM D445, and an optional additive thereby making the polycarbonate composition. The polycarbonate composition has haze less than 1% as determined in accordance with ASTM D1003-07, and can be used for optical applications such as automotive headlamps.

  制造透明度更高的聚碳酸酯组合物的方法包括：在熔融聚合条件下，使芳香族二羟基化合物和碳酸二芳基酯发生反应，生成聚碳酸酯；将聚碳酸酯与聚二有机硅氧烷接触，聚二有机硅氧烷在 25°C 时的运动粘度小于 20 mm2/sec（根据 ASTM D445 测定），聚二有机硅氧烷与任选添加剂接触，生成聚碳酸酯组合物。根据 ASTM D1003-07 测定，该聚碳酸酯组合物的雾度小于 1%，可用于汽车前大灯等光学应用。
• POLYCARBONATE RESIN COMPOSITION FOR THIN OPTICAL COMPONENT, AND METHOD FOR PRODUCING THIN OPTICAL COMPONENT
  申请人：Mitsubishi Chemical Corporation

  公开号：EP3388463A1

  公开（公告）日：2018-10-17

  An object of the present invention is to provide a polycarbonate resin composition for a thin optical component, which polycarbonate resin composition has favorable fluidity as well as excellent strength. This object is achieved by a polycarbonate resin composition for a thin optical component, which composition contains: 100 parts by mass of an aromatic polycarbonate resin (A) having a viscosity average molecular weight (Mv) of 10,000 to 15,000; and 2 to 100 parts by mass of an aromatic polycarbonate copolymer (B) including a carbonate structural unit (i) represented by a particular Formula (1) and a carbonate structural unit (ii) represented by a particular Formula (2), wherein the ratio of the carbonate structural unit (i) to a total of 100 mol% of the carbonate structural unit (i) and the carbonate structural unit (ii) in the aromatic polycarbonate copolymer (B) is more than 10 mol% and less than 39 mol%.

  本发明的目的是提供一种用于薄型光学元件的聚碳酸酯树脂组合物，该聚碳酸酯树脂组合物具有良好的流动性和优异的强度。本发明的目的是通过一种用于薄型光学元件的聚碳酸酯树脂组合物来实现的，该组合物包含100 质量份的芳香族聚碳酸酯树脂 (A)，其粘度平均分子量 (Mv) 在 10,000 至 15,000 之间；和 2 至 100 质量份的芳香族聚碳酸酯共聚物 (B)，包括由特定式 (1) 表示的碳酸酯结构单元 (i) 和由特定式 (2) 表示的碳酸酯结构单元 (ii)，其中碳酸酯结构单元 (i) 与芳香族聚碳酸酯共聚物 (B) 中碳酸酯结构单元 (i) 和碳酸酯结构单元 (ii) 的总计 100 摩尔%的比例大于 10 摩尔%，小于 39 摩尔%。