Bernsteinsaeureester des β-Dimethylaminoaethanols u. 5α-Pyridoxins, Maleinsaeure | 33510-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Bernsteinsaeureester des β-Dimethylaminoaethanols u. 5α-Pyridoxins, Maleinsaeure
• 英文别名: 2-(dimethylamino)ethyl [5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl succinate, salt with maleic acid (1:1)；2-(Dimethylamino)ethyl (5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)methyl succinate, salt with maleic acid (1:1)；(Z)-but-2-enedioic acid;1-O-[2-(dimethylamino)ethyl] 4-O-[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl] butanedioate
• CAS: 33510-78-0
• 化学式: C₄H₄O₄*C₁₆H₂₄N₂O₆
• 分子量: 456.45
• InChiKey: BSODAHUAXQQFMG-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.23
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  184
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs)
  申请人：NYCOMED DANMARK A/S

  公开号：EP1017370A1

  公开（公告）日：2000-07-12
• QUICK RELEASE PHARMACEUTICAL COMPOSITIONS OF DRUG SUBSTANCES
  申请人：NYCOMED DANMARK A/S

  公开号：EP1109534A1

  公开（公告）日：2001-06-27
• Quick release pharmaceutical compositions of drug substances
  申请人：Bertelsen Egon Poul

  公开号：US20050147668A1

  公开（公告）日：2005-07-07

  The present invention relates to an oral modified release pharmaceutical composition for the administration of a therapeutically and/or prophylactically effective amount of an active substance (a drug substance) to obtain a relatively fast or quick onset of the therapeutic and/or prophylactic effect The drug substances contained in a modified release pharmaceutical composition according to the invention are suitably a drug substance which has a very low solubitity under acidic conditions, i.e. under conditions similar to those present in the stomach and/or drug substances which have a pK a value below about 5.5 such as in a range of from about 4 to about 5. The composition is based on a powder comprising a therapeutically and/or prophylactically active substance and has such a particle size that when the powder is subjected to a sieve analysis, then at least about 90% w/w of the particles passes through sieves 180 μm and the powder is contacted with an aqueous medium to form a particulate composition, which has such a particle size that when the particulate composition is subjected to a sieve analysis, then at least about 50% w/w of the particles passes through sieve 180 μm. Furthermore, the composition, when tested in accordance with the dissolution method (1) defined herein employing 0.07 N hydrochloric acid as dissolution medium, releases at least about 50% w/w of the active substance within the first 20 min of the test
• US6599529B1
  申请人：——

  公开号：US6599529B1

  公开（公告）日：2003-07-29
• US6713089B1
  申请人：——

  公开号：US6713089B1

  公开（公告）日：2004-03-30