1,1-dianisyl-2,2,2-trichloroethyl chloride | 101119-50-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-dianisyl-2,2,2-trichloroethyl chloride
• 英文别名: 1,1-dianisyl-1,2,2,2-tetrachloroethane；1-Methoxy-4-[1,2,2,2-tetrachloro-1-(4-methoxyphenyl)ethyl]benzene
• CAS: 101119-50-0
• 化学式: C₁₆H₁₄Cl₄O₂
• 分子量: 380.098
• InChiKey: HHVBKWPTUGFWCA-UHFFFAOYSA-N

物化性质

• 熔点：
  152 °C
• 沸点：
  455.8±45.0 °C(Predicted)
• 密度：
  1.358±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1-dianisyl-2,2,2-trichloroethyl chloride 以60%的产率得到
  参考文献：
  名称：

  Karl Rosa Maria, Kloesel Roland, Koenig Stephan, Lehnhoff Stefan, Ugi Iva+, Tetrahedron, 51 (1995) N 13, S 3759-3766

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-dianisyl-2,2,2-trichloroethanol 在 吡啶 、 氯化亚砜 作用下， 以 苯 为溶剂， 反应 0.5h， 以86%的产率得到1,1-dianisyl-2,2,2-trichloroethyl chloride
  参考文献：
  名称：

  1,1-二苯胺基-2,2,2-三氯乙基醚—羟基的新保护

  摘要：

  β-卤代烷基保护基已经确立，但是，缺乏适当的保护，特别是对于羧基和邻羟基。现在，通过设计1,1-二苯甲酰基-2,2,2-三氯乙基（DATE）解决了这个问题。描述了具有DATE部分的模型醇的烷基化反应。所得的β-卤代烯丙基醚被证明对酸和碱具有显着的稳定性。以高收率获得模型醇的脱blocdng。

  DOI：

  10.1016/0040-4020(95)00120-w

文献信息

• The 1,1- dianisyl-2,2,2-trichloroethyl group as 2′-hydroxyl protection of ribonucleotides
  作者：Roland Klösel、Stephan König、Stefan Lehnhoff、Rosa Maria Karl

  DOI：10.1016/0040-4020(95)00981-7

  日期：1996.1

  The 1,1-dianisyl-2,2,2-trichloroethyl group (DATE, 1) was introduced as a new 2′-hydroxyl protecting group of ribonucleotides. The usefulness of DATE as a 2′-OH protection was demonstrated in the solid phase synthesis of a dinucleotide by the phosphoramidite method. Starting from 2′-O-DATE-uridine (5), a suitable protected building block 7 was thus prepared and condensed in a conventional DNA synthesizer

  引入1,1-二茴香基-2,2,2-三氯乙基（DATE，1）作为核糖核苷酸的新2'-羟基保护基。通过亚磷酰胺法在二核苷酸的固相合成中证明了DATE作为2'-OH保护的有用性。从2′-O-DATE-尿苷（5）开始，由此制备合适的受保护的结构单元7，并在常规DNA合成仪中缩合，使胸苷的未受保护的5′-羟基经由3′-羟基与支持物结合。团体。将所得的嵌合二核苷酸从支持物上切下，除去保护基，得到8。。DATE的切割通过锂钴酞菁锂平稳，定量地进行，没有任何副产物的形成
• CYCLIC COMPOUND, PHOTORESIST BASE MATERIAL AND PHOTORESIST COMPOSITION
  申请人：Shibata Mitsuru

  公开号：US20100190107A1

  公开（公告）日：2010-07-29

  A cyclic compound shown by the following formula (I):

  一个由以下公式（I）所示的环状化合物：
• Pseudonucleotide comprising an intercalator
  申请人：Christensen Bech Ulf

  公开号：US20060014144A1

  公开（公告）日：2006-01-19

  The present invention relates to intercalator pseudonucleotides. Intercalator pseudonucleotides according to the invention are capable of being incorporated into the backbone of a nucleic acid or nucleic acid analogue and they comprise an intercalator comprising a flat conjugated system capable of co-stacking with nucleobases of DNA. The invention also relates to oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudo nucleotide. The invention furthermore relates to methods of synthesising intercalator pseudo nucleotides and methods of synthesising oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudonucleotide. In addtition, the invention describes methods of separating sequence specific DNA(s) from a mixture comprising nucleic acids, methods of detecting a sequence specific DNA (target DNA) in a mixture comprising nucleic acids and/or nucleic acid analogues and methods of detecting a sequence specific RNA in a mixture comprising nucleic acids and/or nucleic acid analogues. In particular said methods may involve the use of oligonucleotides comprising intercalator pseudo nucleotides. The invention furthermore relates to pairs of oligonucleotides or oligonucleotide analogues capable of hybridising to one another, wherein said pairs comprise at least one intercalator pseudonucleotide. Methods for inhibiting a DNAse and/or a RNAse and methods of modulating transcription of one or more specific genes are also described.

  本发明涉及插入剂假核苷酸。本发明中的插入剂假核苷酸能够被合并到核酸或核酸类似物的骨架中，它们包括一个插入剂，该插入剂包括一个平面共轭系统，能够与DNA的核碱基共同堆积。本发明还涉及至少包括一个插入剂假核苷酸的寡核苷酸或寡核苷酸类似物。此外，本发明还涉及合成插入剂假核苷酸的方法以及合成至少包括一个插入剂假核苷酸的寡核苷酸或寡核苷酸类似物的方法。此外，本发明还描述了一种从包含核酸的混合物中分离特定序列DNA的方法，检测包含核酸和/或核酸类似物的混合物中的特定序列DNA（目标DNA）的方法以及检测包含核酸和/或核酸类似物的混合物中的特定序列RNA的方法。特别是，这些方法可能涉及使用包括插入剂假核苷酸的寡核苷酸。本发明还涉及能够杂交的寡核苷酸或寡核苷酸类似物的对，其中所述对包括至少一个插入剂假核苷酸。本发明还描述了抑制DNA酶和/或RNA酶的方法以及调节一个或多个特定基因的转录的方法。
• PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR
  申请人：Christensen Ulf Bech

  公开号：US20100121056A1

  公开（公告）日：2010-05-13

  The present invention relates to intercalator pseudonucleotides. Intercalator pseudonucleotides according to the invention are capable of being incorporated into the backbone of a nucleic acid or nucleic acid analogue and they comprise an intercalator comprising a flat conjugated system capable of co-stacking with nucleobases of DNA. The invention also relates to oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudo nucleotide. The invention furthermore relates to methods of synthesising intercalator pseudo nucleotides and methods of synthesising oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudonucleotide. In addition, the invention describes methods of separating sequence specific DNA(s) from a mixture comprising nucleic acids, methods of detecting a sequence specific DNA (target DNA) in a mixture comprising nucleic acids and/or nucleic acid analogues and methods of detecting a sequence specific RNA in a mixture comprising nucleic acids and/or nucleic acid analogues. In particular said methods may involve the use of oligonucleotides comprising intercalator pseudo nucleotides. The invention furthermore relates to pairs of oligonucleotides or oligonucleotide analogues capable of hybridising to one another, wherein said pairs comprise at least one intercalator pseudonucleotide. Methods for inhibiting a DNAse and/or a RNAse and methods of modulating transcription of one or more specific genes are also described.

  本发明涉及插入剂伪核苷酸。本发明的插入剂伪核苷酸能够被合并到核酸或核酸类似物的骨架中，并且它们包括一个插入剂，该插入剂包含一个平面共轭系统，能够与DNA的碱基共堆叠。本发明还涉及至少包括一个插入剂伪核苷酸的寡核苷酸或寡核苷酸类似物。此外，本发明还涉及合成插入剂伪核苷酸的方法以及合成至少包括一个插入剂伪核苷酸的寡核苷酸或寡核苷酸类似物的方法。此外，本发明还描述了从包括核酸的混合物中分离序列特异性DNA的方法，检测包括核酸和/或核酸类似物的混合物中的序列特异性DNA（目标DNA）的方法，以及检测包括核酸和/或核酸类似物的混合物中的序列特异性RNA的方法。特别是所述方法可能涉及使用包括插入剂伪核苷酸的寡核苷酸。本发明还涉及能够杂交到一起的寡核苷酸或寡核苷酸类似物的配对，其中所述配对包括至少一个插入剂伪核苷酸。还描述了抑制DNA酶和/或RNA酶的方法以及调节一个或多个特定基因的转录的方法。
• The 1,1-Dianisyl-2,2,2-trichloroethyl Moiety as a New Protective Group for the Synthesis of Dinucleostde Trifluoromethylphosphonates
  作者：Rosa Maria Karl、Wolfgang Richter、Roland Klösel、Michael Mayer、Ivar Ugi*

  DOI：10.1080/07328319608002391

  日期：1996.1

  The new 1,1-Dianisyl-2,2,2-trichloroethyl moiety (DATE) is used as an acid and base stable protective group for nucleosides. 5'-O-DATE-thymidine and 3'-O-acetylthymidine are phosphorylated with CF3P(NR(2))(2) to the corresponding thymidine trifluoromethylphosphonous amidites. These building blocks are coupled with appropriate protected thymidines to a dinucleotide trifluoromethylphosphonate.