N-(4-aminobutyl)amphetamine | 111897-67-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-aminobutyl)amphetamine
• 英文别名: aminobutyl amphetamine；N'-(1-phenylpropan-2-yl)butane-1,4-diamine
• CAS: 111897-67-7
• 化学式: C₁₃H₂₂N₂
• 分子量: 206.331
• InChiKey: PYIXAQHVAATTBL-UHFFFAOYSA-N

物化性质

• 沸点：
  322.4±25.0 °C(Predicted)
• 密度：
  0.947±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-aminobutyl)amphetamine 生成 非那明
  参考文献：
  名称：

  Immunoreagents

  摘要：

  一种免疫荧光测定方法，其特征在于使用一种免疫检测试剂，该试剂是一种类似抗原的物质，包括一种荧光物质和一个与之化学键合的抗原，可能有或没有额外的化学键介入，当抗体靠近时，荧光物质的波长或强度会发生变化，而该抗原对应于该抗体。

  公开号：

  US05243074A1

文献信息

• Detection of Methamphetamine Group Drugs
  申请人：Jehanli Ahmed Mohammed Taki

  公开号：US20080286816A1

  公开（公告）日：2008-11-20

  The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.

  本发明提供了高度特异性的免疫测定，用于检测生物样品中的甲基苯丙胺和其他甲基苯丙胺类滥用药物，如摇头丸和其他摇头丸类药物。更具体地，提供了竞争性测定，包括：(a)将样品与(i)伪麻黄碱/载体共轭物和(ii)能够结合甲基苯丙胺类药物和该共轭物的抗体接触；(b)确定抗体对共轭物的结合是否因样品的存在而减少，结合减少表明样品中含有甲基苯丙胺类药物。
• Fluorescence immunoassay method utilizing pseudo-antigens combined with fluorescent quenchers
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP0343346A1

  公开（公告）日：1989-11-29

  A fluorescence immunoassay method is described in which the presence or absence of antigen is measured within one minute by measuring a variation in fluorescence emitted from an antibody. The method comprises reaction between a pseudo-antigen obtained by chemical combination of an antigen and a fluorescent quencher and an antibody by which fluorescence to be emitted from the antibody is quenched by the action of the quencher combined. When an analyte is added to a solution of the combination, the pseudo-antigen is replaced by an antigen if the analyte contains the antigen, so that the fluorescence increases in intesity. This intensity is measured and compared with the initially measured intensity to detect the presence of the antigen. The method does not make use of the action of antigen on antibody with respect to the fluorescence of the antibody and is applicable to all antigens.

  描述了一种荧光免疫测定方法，该方法通过测量抗体发出的荧光变化，在一分钟内测定抗原的存在与否。该方法包括通过抗原和荧光淬灭剂的化学结合得到的假抗原与抗体之间的反应，抗体发出的荧光在淬灭剂的作用下被淬灭。当分析物加入组合物溶液中时，如果分析物中含有抗原，假抗原就会被抗原取代，从而使荧光强度增加。测量荧光强度，并将其与最初测量的强度进行比较，以检测抗原的存在。该方法不利用抗原对抗体荧光的作用，适用于所有抗原。
• Antibody having high affinity to methamphetamine and immunogen for obtaining the same
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP0359063A2

  公开（公告）日：1990-03-21

  In producing an antibody using a low molecular substance as an antigen, it is necessary to immunize with an immunogen which is prepared by binding the antigen to protein. Therefore, it is difficult to pro­duce an antibody having a high affinity to the antigen. According to the present invention, investigations were made, paying attention to the molecular structure, especially the structure at the site binding to protein, of the antigen in production of the immunogen. As the result, there is used a process which comprises pre­paring an antigen derivative (e.g., aminobutyl amphet­amine) using a compound (e.g., amphetamine) having such a structure that an alkyl group of the desired antigen (e.g., methamphetamine) is replaced with hydrogen atom, and then binding the antigen derivative with protein. Immunization using the thus obtained immunogen gives an antibody having a high affinity to methamphetamine and improved sensitivity of immunoassay by about 1000 times. Furthermore, by this immunogen, a monoclonal antibody having a high affinity to methamphetamine can be produced.

  在使用低分子物质作为抗原生产抗体时，必须使用通过将抗原与蛋白质结合而制备的免疫原进行免疫。因此，很难制备出与抗原具有高亲和力的抗体。根据本发明，对生产免疫原时抗原的分子结构，特别是与蛋白质结合部位的结构进行了研究。因此，本发明采用了一种工艺，该工艺包括用一种化合物（如安非他明）制备抗原衍生物（如氨基丁基安非他明），该化合物具有这样的结构，即所需抗原（如甲基安非他明）的烷基被氢原子取代，然后将抗原衍生物与蛋白质结合。使用这样得到的免疫原进行免疫，可得到对甲基苯丙胺具有高亲和力的抗体，免疫测定的灵敏度可提高约 1000 倍。此外，利用这种免疫原还可以制备出对甲基苯丙胺具有高亲和力的单克隆抗体。
• Immunoassay and immunoreagents
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP0430020A1

  公开（公告）日：1991-06-05

  An immunofluorescent assay method, characterized in using an immunodetective reagent, which is an antigen-­like substance comprising a fluorescent substance and an antigen chemically bonded thereto with or without inter­vention of an additional chemical bond, said fluorescent substance being changed in the wavelength or intensity of the fluorescence when an antibody comes close thereto, and said antigen being specific to said antibody.

  一种免疫荧光检测方法，其特征在于使用一种免疫检测试剂，该试剂是一种抗原样物质，由荧光物质和抗原通过或不通过额外的化学键结合而成，当抗体靠近所述荧光物质时，所述荧光物质的荧光波长或强度会发生变化，而所述抗原对所述抗体具有特异性。
• DETECTION OF METHAMPHETAMINE GROUP DRUGS
  申请人：Cozart Bioscience Limited

  公开号：EP1756575B1

  公开（公告）日：2008-10-22