| 219740-05-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• CAS: 219740-05-3
• 化学式: C₃₃H₄₄O₇SSi
• 分子量: 612.86
• InChiKey: WZHLMTSMOCUPBW-NBJHOTSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.21
• 重原子数：
  42.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  88.13
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 lithium tri-t-butoxyaluminum hydride 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities

  摘要：

  Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00540-x
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 生成
  参考文献：
  名称：

  Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities

  摘要：

  Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00540-x

文献信息

• Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities
  作者：Koichiro Morihira、Toshiyuki Nishimori、Hiroyuki Kusama、Yoshiaki Horiguchi、Isao Kuwajima、Takashi Tsuruo

  DOI：10.1016/s0960-894x(98)00540-x

  日期：1998.11

  Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells. (C) 1998 Elsevier Science Ltd. All rights reserved.