1-(2-methylaziridin-1-yl)propan-2-ol | 133888-45-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(2-methylaziridin-1-yl)propan-2-ol
• CAS: 133888-45-6
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: CJOCKSGVKIOKFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-methylaziridin-1-yl)propan-2-ol 、 1,6-己二异氰酸酯 以 2-甲基四氢呋喃 为溶剂， 生成 1-(2-methylaziridin-1-yl)propan-2-yl N-[6-[1-(2-methylaziridin-1-yl)propan-2-yloxycarbonylamino]hexyl]carbamate
  参考文献：
  名称：

  MULTI-AZIRIDINE COMPOUND

  摘要：

  本发明涉及一种多环氮丙烷化合物，其具有：a) 2至6个以下结构单元（A）：（A），其中R′、R″、R1、R2、R3和R4如本文所定义，m为1至6的整数；b) 一个或多个连接链，其中每个连接链连接两个结构单元A；以及c) 分子量在600道尔顿至5000道尔顿范围内。该多环氮丙烷化合物可用于例如交联溶解和/或分散在水性介质中的羧酸官能聚合物。

  公开号：

  US20210332031A1
• 作为产物：
  描述：

  2-甲基氮丙啶 、 methyloxirane 在 水 作用下， 生成 1-(2-methylaziridin-1-yl)propan-2-ol
  参考文献：
  名称：

  Hydroxyalkyl alkylenimines and method of making same

  摘要：

  公开号：

  US02475068A1

文献信息

• AZIRIDINYL FUNCTIONAL COMPOUND
  申请人：Covestro (Netherlands) B.V.

  公开号：EP4093791A1

  公开（公告）日：2022-11-30
• US4070354A
  申请人：——

  公开号：US4070354A

  公开（公告）日：1978-01-24
• [EN] CROSS-LINKED HYALURONATE COMPOUNDS<br/>[FR] COMPOSES DE HYALURONATE RETICULE
  申请人：GENZYME CORP

  公开号：WO2003089476A1

  公开（公告）日：2003-10-30

  There is disclosed a cross-linked hyaluronate compound obtained by reacting a sodium hyaluronate compound with a polyfunctional aziridine compound as a cross-linking agent. The polyfunctional aziridine compound was added to hyaluronan of various molecular weights in an equivalent ratio of HA/AZ of 1:1 to 1:10, preferably, 1:3 to 1:10, more preferably, 1:3 to 1:5; most preferably 1:4 to 1:5.. The polymeric hydrogel compounds obtained are useful to prevent the formation of post-operative adhesions, designing tissue engineering applications, and the like.
• [EN] MULTI-AZIRIDINE COMPOUND<br/>[FR] COMPOSÉ À PLUSIEURS MOTIFS AZIRIDINE
  申请人：DSM IP ASSETS BV

  公开号：WO2020020714A1

  公开（公告）日：2020-01-30

  The present invention relates to a multi-aziridine compound having: a) from 2 to 6 of the following structural units (A): (A) whereby R', R'', R1, R2, R3 and R4 are as defined herein m is an integer from 1 to 6; b) one or more linking chains wherein each one of these linking chains links two of the structural units A; and c) a molecular weight in the range from 600 Daltons to 5000 Daltons. The multi-aziridine compound can be used for example for crosslinking of for example carboxylic acid functional polymers dissolved and/or dispersed in an aqueous medium.
• [EN] WATERBORNE CROSSLINKER COMPOSITION<br/>[FR] COMPOSITION D'AGENT DE RÉTICULATION À BASE D'EAU
  申请人：COVESTRO NETHERLANDS BV

  公开号：WO2021148563A1

  公开（公告）日：2021-07-29

  The present invention relates to a multi-aziridine crosslinker composition, characterized in that the multi-aziridine crosslinker composition is an aqueous dispersion having a pH ranging from 8 to 14 and comprises a multi-aziridine compound in dispersed form, wherein said multi-aziridine compound has: a. from 2 to 6 of the following structural units A: whereby R1 is H, R2 and R4 are independently chosen from H or an aliphatic hydrocarbon group containing from 1 to 4 carbon atoms, R a is an aliphatic hydrocarbon group containing from 1 to 4 carbon atoms, m is 1, b. one or more linking chains wherein each one of these linking chains links two of the structural units A; and c. a molecular weight in the range from 500 to 10000 Daltons wherein the molecular weight is determined using MALDI-TOF mass spectrometry according to the description.