4-methoxy-benzoic acid N'-acetyl-hydrazide | 54019-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-benzoic acid N'-acetyl-hydrazide
• 英文别名: N-acetyl-N'-(4-methoxy-benzoyl)-hydrazine；N-Acetyl-N'-(4-methoxy-benzoyl)-hydrazin；4-Methoxy-benzoesaeure-(N'-acetyl-hydrazid)；N-(4-methoxybenzoyl)-N'-acetyl-hydrazine；1-acetyl-2-(4-methoxybenzoyl)hydrazine；N'-acetyl-4-methoxybenzohydrazide
• CAS: 54019-08-8
• 化学式: C₁₀H₁₂N₂O₃
• mdl: MFCD00748289
• 分子量: 208.217
• InChiKey: NDMOLWRKCLUBFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methoxy-benzoic acid N'-acetyl-hydrazide 在 polyethylene glycol supported Burgess reagent 作用下， 以 四氢呋喃 为溶剂， 反应 0.03h， 生成 2-(4-methoxyphenyl)-5-methyl-1,3,4-oxadiazole
  参考文献：
  名称：

  在微波条件下使用聚合物负载的Burgess试剂从1,2-二酰基肼合成1,3,4-恶二唑的新方法

  摘要：

  报道了一种新颖有效的方法，其实现1，2-二酰基肼的环脱水以提供1，3，4-恶二唑。聚合物负载的Burgess试剂与单模微波加热结合使用。

  DOI：

  10.1016/s0040-4039(99)00382-2
• 作为产物：
  描述：

  4-甲氧基苯甲酸甲酯 在 肼 作用下， 生成 4-methoxy-benzoic acid N'-acetyl-hydrazide
  参考文献：
  名称：

  Clemence; Joliveau-Maushart; Meier, European Journal of Medicinal Chemistry, 1985, vol. 20, # 3, p. 257 - 266

  摘要：

  DOI：

文献信息

• Novel 4H-1,2,4-triazole derivatives
  申请人：Roussel Uclaf

  公开号：US04659729A1

  公开（公告）日：1987-04-21

  Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all hydrogen having a remarkable analgesic activity and a novel method for their preparation.

  从4H-1,2,4-三唑类化合物中选择的化合物，其化学式为##STR1##其中R.sub.1，R.sub.2，R.sub.3和R.sub.4可能位于苯环的不同位置，R.sub.1，R.sub.3和R.sub.4分别选自氢，-OH，1至4个碳原子的烷基，1至4个碳原子的烷氧基，卤素，-CF.sub.3，-NO.sub.2，-NH.sub.2和NH-AlK和##STR2##R.sub.2选自氢，-OH，1至4个碳原子的烷基，卤素，-CF.sub.3，-NO.sub.2，-NH.sub.2，-NH-AlK和##STR3##和AlK，AlK.sub.1和AlK.sub.2是1至4个碳原子的烷基，或R.sub.1和R.sub.2一起和/或R.sub.3和R.sub.4一起是亚甲二氧基，R选自乙基，-CH.sub.2-COOH和CH.sub.2-COOAlK.sub.3的群，AlK.sub.3是1至4个碳原子的烷基及其无毒、药用可接受的酸盐，但R.sub.1，R.sub.2，R.sub.3和R.sub.4不能都是具有显著镇痛活性和新颖制备方法的氢。
• 4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use
  申请人：Roussel Uclaf

  公开号：US04512997A1

  公开（公告）日：1985-04-23

  Novel 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene rings and are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and --NH--AlK and ##STR2## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting hydrogen, alkyl of 1 to 4 carbon atoms, --CH.sub.2 --COOH and --CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable analgesic activity and a novel method for their preparation.

  4H-1,2,4-三唑类新化合物的分子式为##STR1##其中R.sub.1、R.sub.2、R.sub.3和R.sub.4可以位于苯环的不同位置，分别选择自氢、--OH、1至4个碳原子的烷基、1至4个碳原子的烷氧基、卤素、--CF.sub.3、--NO.sub.2、--NH.sub.2和--NH--AlK和##STR2##以及AlK，AlK.sub.1和AlK.sub.2是1至4个碳原子的烷基，或者R.sub.1和R.sub.2一起和/或R.sub.3和R.sub.4一起是亚甲二氧基，R选择自氢、1至4个碳原子的烷基、--CH.sub.2 --COOH和--CH.sub.2 --COOAlK.sub.3，AlK.sub.3是1至4个碳原子的烷基，它们的无毒、药学上可接受的酸盐具有显著的镇痛活性，以及它们的制备新方法。
• Reactivity of benzohydrazide derivatives towards acetylation reaction. Experimental and theoretical studies
  作者：Paola R. Campodónico、Margarita E. Aliaga、José G. Santos、Enrique A. Castro、Renato Contreras

  DOI：10.1016/j.cplett.2010.01.052

  日期：2010.3

  We herein report an experimental and theoretical study on the acetylation reaction of benzohydrazide derivatives towards p-nitrophenyl acetate (NPA). The kinetic data are consistent with a stepwise mechanism with the nucleophilic attack as the rate determining step. From the theoretical analysis it is found that benzohydrazide derivatives establish intramolecular proton rearrangement. The enol form

  我们在本文中报道了苯并酰肼衍生物对乙酸对硝基苯酯（NPA）的乙酰化反应的实验和理论研究。动力学数据与亲核攻击作为速率确定步骤的逐步机制是一致的。从理论分析发现苯甲酰肼衍生物建立了分子内质子重排。烯醇形式表现为亲核攻击的活性物质。提出了结合酮-烯醇预平衡的反应机理。该研究以描述亲核攻击最活跃的中心的局部反应性分析以及描述诱导性取代基效应的位点活化分析完成。
• Near-infrared-absorbing organic electrochromic materials
  申请人：Wang Zhi Yuan

  公开号：US20080188678A1

  公开（公告）日：2008-08-07

  The invention provides generally a new type of organic electrochromic Near Infrared (NIR)-active materials capable of absorbing and attenuating the light in the NIR region around 1550 nm and forming thin films on electrodes for variable optical attenuator (VOA) applications. They have utility in planar VOA devices. The materials are ruthenium complexes. Unsymmetrical complexes having two different substituents are disclosed, where one substituent is more electron-donating than the other. Complexes which are dimers or trimers (symmetrical or unsymmetrical) are disclosed, as are polymeric complexes. Crosslinked polymeric complex films are also disclosed.

  该发明通常提供了一种新型的有机电致变色近红外（NIR）活性材料，能够吸收和衰减大约1550纳米附近的NIR区域的光，并形成薄膜在电极上，用于可变光学衰减器（VOA）应用。它们在平面VOA设备中具有实用性。这些材料是钌配合物。披有两种不同取代基的非对称配合物被披露，其中一个取代基比另一个更具电子给予性。披有二聚体或三聚体（对称或非对称）的配合物被披露，以及聚合物配合物。还披露了交联聚合物复合薄膜。
• Organic electrochromic materials and polymers for optical attenuation in the near infrared region
  申请人：——

  公开号：US20030010963A1

  公开（公告）日：2003-01-16

  The invention provides generally a new type of organic electrochromic Near Infrared (NIR)-active materials capable of absorbing and attenuating the light in the NIR region around 1550 nm and forming thin films on electrodes for variable optical attenuator (VOA) applications. They have utility in planar VOA devices. The materials are ruthenium complexes. Unsymmetrical complexes having two different substituents are disclosed, where one substituent is more electron-donating than the other. Complexes which are dimers or trimers (symmetrical or unsymmetrical) are disclosed, as are polymeric complexes. Crosslinked polymeric complex films are also disclosed.

  本发明提供了一种新型的有机电致变色近红外(NIR)活性材料，能够吸收和衰减大约1550纳米左右的NIR区域的光，并形成薄膜在电极上，用于可变光学衰减器(VOA)应用中。它们在平面VOA器件中具有实用性。这些材料是钌配合物。披露了具有两个不同取代基的非对称配合物，其中一个取代基比另一个更电子给予。披露了二聚体或三聚体(对称或非对称)的配合物，以及聚合物配合物。还披露了交联聚合物配合物薄膜。