[5-(phenylmethyloxycarbonyl)amino-6-oxo-hexyl]-carbamic acid tert-butyl ester | 885125-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-(phenylmethyloxycarbonyl)amino-6-oxo-hexyl]-carbamic acid tert-butyl ester
• 英文别名: (5-benzyloxycarbonylamino-6-oxo-hexyl)-carbamic acid tert-butyl ester；benzyl N-[6-[(2-methylpropan-2-yl)oxycarbonylamino]-1-oxohexan-2-yl]carbamate
• CAS: 885125-79-1
• 化学式: C₁₉H₂₈N₂O₅
• 分子量: 364.442
• InChiKey: BFUORGBCUVFHDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [5-(phenylmethyloxycarbonyl)amino-6-oxo-hexyl]-carbamic acid tert-butyl ester 、 丙酮氰醇 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.5h， 生成 [5-(phenylmethyloxycarbonyl)amino-6-cyano-6-hydroxy-hexyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  WO2006/44133

  摘要：

  公开号：
• 作为产物：
  描述：

  N⁶-Boc-N²-Cbz-lysine 在 sodium hypochlorite 、 2,2,6,6-四甲基哌啶氧化物 、 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 反应 0.33h， 生成 [5-(phenylmethyloxycarbonyl)amino-6-oxo-hexyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Complexes and Ligands

  摘要：

  本申请提供了配体和包括这些配体的荧光或发光配合物。

  公开号：

  US20220025254A1

文献信息

• [EN] DI-MACROCYCLES<br/>[FR] DI-MACROCYCLES
  申请人：LUMIPHORE INC

  公开号：WO2014078690A1

  公开（公告）日：2014-05-22

  The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

  这项发明涉及可用于治疗和诊断应用的化合物和复合物。
• [EN] MACROCYCLIC HOPO CHELATORS<br/>[FR] CHÉLATEURS HOPO MACROCYCLIQUES
  申请人：LUMIPHORE INC

  公开号：WO2011025790A1

  公开（公告）日：2011-03-03

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一种新型的大环化合物类别，以及由金属离子（例如，镧系元素）与本发明的化合物形成的配合物。首选的配合物在水介质中表现出高稳定性，以及镧系离子的发光量子产率高，而无需辅助激活剂。首选的化合物包括其大环结构中的羟基吡啶酮基团，并以对多种多肽（如抗体和蛋白质）的非特异性结合惊人地低以及高动力学稳定性为特征。
• LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
  申请人：Raymond Kenneth N.

  公开号：US20080213917A1

  公开（公告）日：2008-09-04

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

  本发明提供了一种新的大环化合物类别，以及由金属（例如镧系金属）离子和本发明中化合物形成的配合物。首选的配合物在水介质中表现出高稳定性以及高量子产率的镧系离子发光特性，无需使用次级活化剂。首选化合物在其大环结构中包含羟基异苯酰胺基团，并以惊人的低非特异性结合多种多肽（如抗体和蛋白质）以及高动力学稳定性为特征。这些特征使它们与已知的开放结构配体有所区别。
• MACROCYCLIC HOPO CHELATORS
  申请人：Butlin Nathaniel G.

  公开号：US20120214253A1

  公开（公告）日：2012-08-23

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一类新型的大环化合物，以及由金属（例如镧系金属）离子和本发明中的化合物形成的络合物。优选的络合物在无需次级活化剂的情况下，具有高稳定性和高量子产率的镧系离子荧光。优选的化合物在它们的大环结构中包括羟基吡啶酮基团，并且其特点是与各种多肽（如抗体和蛋白质）具有惊人的低非特异性结合和高动力学稳定性。
• DI-MACROCYCLES
  申请人：LUMIPHORE, INC.

  公开号：US20160221971A1

  公开（公告）日：2016-08-04

  The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

  本发明涉及可用于治疗和诊断应用的化合物和复合物。