propane-1,2,3-triyl tris(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) | 6386-64-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: propane-1,2,3-triyl tris(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)
• 英文别名: Glycerin-tris-(3,5-di-t-butyl-4-hydroxyphenyl)-propionat；2,3-Bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]propyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate
• CAS: 6386-64-7
• 化学式: C₅₄H₈₀O₉
• 分子量: 873.224
• InChiKey: PNZLJNVUTPFUIE-UHFFFAOYSA-N

物化性质

• 沸点：
  776.0±60.0 °C(Predicted)
• 密度：
  1.071±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  63
• 可旋转键数：
  23
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  3-(3,5-二叔丁基-4-羟基苯基)丙酸 、 甘油 在 1,4-二甲基吡啶鎓对甲苯磺酸盐 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以70%的产率得到propane-1,2,3-triyl tris(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)
  参考文献：
  名称：

  Synthesis, characterisation, and performance evaluation of tri-armed phenolic antioxidants

  摘要：

  In this study, a series of core units (glycerol, triethanolamine and triisopropanolamine derivatives) were investigated for their use in tri-armed phenolic antioxidants. The antioxidant ability of these tri-armed phenolic compounds featuring different core units were then evaluated in a hydrocarbon lubricant using differential scanning calorimetry (DSC) and compared to the commercially available antioxidants Irganox L135 and Irganox L57. An impressive oxidation induction time of ca. 9-12 min was observed for the glycerol based antioxidants when compared to the commercial antioxidants (ca. 4-6 min), whereas in contrast in the case of triethanolamine and triisopropanolamine derived antioxidants, a solubilising unit was incorporated in order to provide appropriate solubility within the hydrocarbon medium and revealed an excellent oxidation induction time of ca. 11-12 min. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152127

文献信息

• Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans
  申请人：——

  公开号：US20030162753A1

  公开（公告）日：2003-08-28

  The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.

  化合物的化学式（I）为亲水性芳基磷酸酯、硫代磷酸酯和氨基磷酸酯，是肠道顶端膜Na介导的磷酸盐共同运输抑制剂。这些化合物可以经口服给药，在肠道中起到抑制Na依赖性磷酸盐摄取的作用，或者内部给药，在肾脏和甲状旁腺的磷酸盐控制功能中发挥作用。它们可用于抑制钠介导的磷酸盐摄取，降低血清PTH、钙、钙三醇和磷酸盐，治疗动物（包括人类）的肾脏疾病。
• Inhibitors of intestinal apical membrane Na/phosphate co-transportation
  申请人：——

  公开号：US20020133036A1

  公开（公告）日：2002-09-19

  The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.

  式（I）的化合物是亲水性芳基磷酸酯、硫代磷酸酯和氨基磷酸酯肠道顶端膜Na介导的磷酸共运输抑制剂。这些化合物可通过口服给药，在肠道内起到抑制依赖Na的磷酸摄取的作用，或在体内与肾脏和甲状旁腺的磷酸控制功能相互作用。因此，它们对于抑制钠介导的磷酸摄取、降低血清PTH、钙、活性维生素D和磷酸盐，以及治疗动物（包括人类）的肾脏疾病非常有用。
• POLYACETAL RESIN COMPOSITION AND MOLDINGS
  申请人：——

  公开号：US20030158301A1

  公开（公告）日：2003-08-21

  The polyacetal resin composition contains about 0.01-10 parts by weight of a glyoxyldiureide compound per 100 parts by weight of polyacetal resin. The glyoxyldiureide compound includes glyoxyldiureide and its derivatives (metal salts etc.). Optionally, about 0.01-10 parts by weight of a basic nitrogen-containing compound is further added. The basic nitrogen-containing compound includes melamine, melamine resin, and polyamide resin. Further, an antioxidant may be further added. The above composition contributes to stability, particularly heat stability, of polyacetal resin and suppression of emission of formaldehyde.

  聚乙二醇树脂组成物含有每100份聚乙二醇树脂约0.01-10份重量的甘氧基二脲化合物。该甘氧基二脲化合物包括甘氧基二脲及其衍生物（金属盐等）。可选择地，还可进一步添加约0.01-10份重量的碱性含氮化合物。碱性含氮化合物包括三聚氰胺、三聚氰胺树脂和聚酰胺树脂等。此外，还可以进一步添加抗氧化剂。以上组成物有助于提高聚乙二醇树脂的稳定性，特别是热稳定性，并抑制甲醛的排放。
• Polyacetal resin composition and moldings
  申请人：Harashina Hatsuhiko

  公开号：US20050075429A1

  公开（公告）日：2005-04-07

  The polyacetal resin composition contains about 0.01-10 parts by weight of a glyoxyldiureide compound per 100 parts by weight of polyacetal resin. The glyoxyldiureide compound includes glyoxyldiureide and its derivatives (metal salts etc.). Optionally, about 0.01-10 parts by weight of a basic nitrogen-containing compound is further added. The basic nitrogen-containing compound includes melamine, melamine resin, and polyamide resin. Further, an antioxidant may be further added. The above composition contributes to stability, particularly heat stability, of polyacetal resin and suppression of emission of formaldehyde.

  聚乙二醇树脂组合物含有每100份聚乙二醇树脂约0.01-10份重量的乙酰基尿素化合物。乙酰基尿素化合物包括乙酰基尿素及其衍生物（金属盐等）。可选地，还可以进一步添加约0.01-10份重量的含有碱性氮化合物。碱性氮化合物包括三聚氰胺，三聚氰胺树脂和聚酰胺树脂。此外，还可以进一步添加抗氧化剂。上述组合物有利于聚乙二醇树脂的稳定性，特别是热稳定性，并抑制甲醛的排放。
• Stabilized ethylene/chlorotrifluoroethylene copolymer composition
  申请人：Ausimont, U.S.A., Inc.

  公开号：EP0069195A2

  公开（公告）日：1983-01-12

  About equimolar ethylene/chlorotrifluoroethylene copolymer compositions are stabilized against thermal degradation by incorporating therein a stabilizing system comprising (a) a phosphate of an organic polyhydric phenol; (b) a salt of a carboxylic acid and a metal of Group II of the Periodic Table; and (c) an ester of a (4-hydroxy-5-alkylphenyl)alkanoic acid.

  通过在约等摩尔乙烯/三氟氯乙烯共聚物组合物中加入稳定体系来防止热降解，该稳定体系包括：(a) 有机多氢酚的磷酸酯；(b) 羧酸和元素周期表第二族金属的盐；(c) (4-羟基-5-烷基苯基)烷酸的酯。