AC915 | 259729-84-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: AC915
• 英文别名: Benzeneacetic acid, 3,4-dichloro-, 2-(1-pyrrolidinyl)ethyl ester；2-pyrrolidin-1-ylethyl 2-(3,4-dichlorophenyl)acetate
• CAS: 259729-84-5；6692-13-3
• 化学式: C₁₄H₁₇Cl₂NO₂
• 分子量: 302.2
• InChiKey: CYVORFBBJKNNDO-UHFFFAOYSA-N

物化性质

• 沸点：
  402.8±40.0 °C(Predicted)
• 密度：
  1.267±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(2-羟乙基)-吡咯烷 、 3,4-二氯苯乙酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 生成 AC915
  参考文献：
  名称：

  A sigma-1 receptor selective analogue of BD1008. a potential substitute for (+)-opioids in sigma receptor binding assays

  摘要：

  A simple, achiral monoamine sigma-1 (sigma(1)) receptor selective ligand (sigma(2)K/sigma(i) K-i > 2000) is described, which could replace the chiral (+)-pentazocine or dextrallorphan as a sigma(1) masking agent in sigma(2) binding assays. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00590-9

文献信息

• [EN] THERAPY AND PREVENTION OF TDP-43 PROTEINOPATHY<br/>[FR] THÉRAPIE ET PRÉVENTION D'UNE PROTÉINOPATHIE TDP-43
  申请人：POWMRI LTD

  公开号：WO2010015040A1

  公开（公告）日：2010-02-11

  The present invention provides methods for the therapy and prevention of TDP-43 proteinopathies and for the treatment of neuronal cells having elevated cytoplasmic TDP-43 comprising administration of one or more modulators of OPRS1 activity and/or level and/or expression sufficient to reduce, inhibit, prevent or delay cytoplasmic sequestration and/or cytoplasmic accumulation of TDP-43 protein in neuroglia and/or neuronal cells. The present invention also provides methods of identifying, isolating and formulating modulators of OPRS1 activity and/or level and/or expression for use in the preparation of a compositions for the treatment or prevention of a TDP-43 proteinopathy or for reducing cytoplasmic sequestration and/or cytoplasmic accumulation of TDP-43 protein in a neuronal cell having cytoplasmic elevated TDP-43 level.
• A sigma-1 receptor selective analogue of BD1008. a potential substitute for (+)-opioids in sigma receptor binding assays
  作者：Dean Y. Maeda、Wanda Williams、Wayne D. Bowen、Andrew Coop

  DOI：10.1016/s0960-894x(99)00590-9

  日期：2000.1

  A simple, achiral monoamine sigma-1 (sigma(1)) receptor selective ligand (sigma(2)K/sigma(i) K-i > 2000) is described, which could replace the chiral (+)-pentazocine or dextrallorphan as a sigma(1) masking agent in sigma(2) binding assays. (C) 1999 Elsevier Science Ltd. All rights reserved.