5-(3,5-dimethoxyphenethyl)furan-2-carbaldehyde | 1159426-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(3,5-dimethoxyphenethyl)furan-2-carbaldehyde
• 英文别名: 5-[2-(3,5-Dimethoxyphenyl)ethyl]furan-2-carbaldehyde；5-[2-(3,5-dimethoxyphenyl)ethyl]furan-2-carbaldehyde
• CAS: 1159426-39-7
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: BBUDRXPOIRSBSX-UHFFFAOYSA-N

物化性质

• 沸点：
  396.0±42.0 °C(predicted)
• 密度：
  1.154±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-氯-2-糠醛 、 在 potassium fluoride 、 palladium diacetate 、 potassium carbonate 、 2-二环己膦基-2'-(N,N-二甲胺)-联苯 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 水 、 甲苯 为溶剂， 反应 24.0h， 以54.8 mg的产率得到5-(3,5-dimethoxyphenethyl)furan-2-carbaldehyde
  参考文献：
  名称：

  Utilization of Potassium Vinyltrifluoroborate in the Development of a 1,2-Dianion Equivalent

  摘要：

  Previous studies of orthogonally reactive dibora species led to the discovery of a unique reactivity pattern associated with potassium vinyltrifluoroborate. Upon hydroboration, the vinyltrifluoroborate generates a 1,2-diboraethane, which is distinct from the 1,1-dibora intermediates generated when traditional alkenyldialkylboron species undergo hydroboration. The 1,2-dianion equivalent thus generated can be envisioned as a building block for the linkage of two different electrophiles via palladium-catalyzed Suzuki-Miyaura cross-couplings.

  DOI：

  10.1021/ol900822j

文献信息

• Utilization of Potassium Vinyltrifluoroborate in the Development of a 1,2-Dianion Equivalent
  作者：Gary A. Molander、Deidre L. Sandrock

  DOI：10.1021/ol900822j

  日期：2009.6.4

  Previous studies of orthogonally reactive dibora species led to the discovery of a unique reactivity pattern associated with potassium vinyltrifluoroborate. Upon hydroboration, the vinyltrifluoroborate generates a 1,2-diboraethane, which is distinct from the 1,1-dibora intermediates generated when traditional alkenyldialkylboron species undergo hydroboration. The 1,2-dianion equivalent thus generated can be envisioned as a building block for the linkage of two different electrophiles via palladium-catalyzed Suzuki-Miyaura cross-couplings.