2,2,3,3-tetrafluoropropionitrile | 425-85-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2,3,3-tetrafluoropropionitrile
• 英文别名: 2,2,3,3-tetrafluoropropanenitrile
• CAS: 425-85-4
• 化学式: C₃HF₄N
• 分子量: 127.041
• InChiKey: PIORIRQBACOORT-UHFFFAOYSA-N

物化性质

• 沸点：
  27.4±40.0 °C(Predicted)
• 密度：
  1.356±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  2,2,3,3-tetrafluoropropionitrile 在 silver fluoride 、 氯 作用下， 生成 N-Chlor-3H-pentafluorpropyliden-imin
  参考文献：
  名称：

  The Synthesis and Chemistry of Fluoroazoalkanes

  摘要：

  DOI：

  10.1021/ja00871a014
• 作为产物：
  描述：

  2,2,3,3-四氟丙胺 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 2,2,3,3-tetrafluoropropionitrile
  参考文献：
  名称：

  Activated dimethyl sulfoxide dehydration of amide and its application to one-pot preparation of benzyl-type perfluoroimidates

  摘要：

  Various types of primary amides were treated under an activated dimethyl sulfoxide (DMSO) species, (COCl)(2)-DMSO and Et3N, as a dehydrating agent to obtain nitriles in excellent yield. This dehydration system was extended to a one-pot preparation of perfluoroimidates via volatile perfluoronitriles from perfluoroamides. Fifteen benzyl-type perfluoroimidates can be prepared in 70-90% yield as more stable imidates than the trichloro analogue. MPM- and DMPM-perfluoroimidates can be used to protect alcohols in place of the trichloroacetimidate with excellent chemical properties and in comparable yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00304-6

文献信息

• Condensation of nitriles of polyhalogenated carboxylic acids and benzonitrile with 2-hydroxy-4,6-dimethylacetophenone
  作者：V. Ya. Sosnovskikh

  DOI：10.1007/bf02498966

  日期：1998.2

  Condensation of 2-hydroxy-4,6-dimethylacetophenone with trifluoro- and trichloroacetonitriles gives 2-amino-5,7-dimethyl-2-trifluoro(trichloro)methyl-4-chromanones. The condensation with 2,2,3,3-tetrafluoropropionitrile, perfluorovaleronitrile, and benzonitrile stops at the stage of formation of the corresponding enamines.

  2-羟基-4,6-二甲基苯乙酮与三氟和三氯乙腈的缩合得到2-氨基-5,7-二甲基-2-三氟（三氯）甲基-4-色满酮。与 2,2,3,3-四氟丙腈、全氟戊腈和苄腈的缩合在相应烯胺形成阶段停止。
• Methods for preparing lower alkyl .alpha.-fluoro-.alpha.-cyanoacetate
  申请人：Daikin Kogyo Co., Ltd.

  公开号：US04540524A1

  公开（公告）日：1985-09-10

  A method for preparing lower alkyl .alpha.-fluoro-.alpha.-cyanoacetate and its carbanion by reacting hexafluoropropene with ammonia, and then reacting the obtained product with an alkali hydroxide in a lower alkyl alcohol. The carbanion is prepared by reacting the product .alpha.-fluoro-.alpha.-cyanoacetate with an alkali fluoride.

  通过将六氟丙烯与氨反应，然后将得到的产物与碱性羟基化合物在较低烷基醇中反应，制备较低烷基α-氟α-氰基乙酸酯及其碳负离子的方法。碳负离子是通过将产物α-氟α-氰基乙酸酯与碱性氟化物反应制备的。
• Aizikovich, A. Ya.; Pashkevich, K. I.; Gorshkov, V. V., Journal of general chemistry of the USSR, 1980, p. 1523 - 1527
  作者：Aizikovich, A. Ya.、Pashkevich, K. I.、Gorshkov, V. V.、Rudaya, M. N.、Postovskii, I. Ya.

  DOI：——

  日期：——
• Reactions of aromatic methyl ketimines with halonitriles as a new route to pyrimidines with two polyhaloalkyl groups
  作者：Vyacheslav Ya Sosnovskikh、Boris I Usachev、Gerd-Volker Röschenthaler

  DOI：10.1016/s0040-4020(01)01231-5

  日期：2002.2

  N-Isopropyl-(1-phenylethylidene)amine reacts with trichloroacetonitrile to give 1-azabutadiene derivative, which undergoes a double addition reaction with a variety of halonitriles affording fluoro- and chloro-containing pyrimidines. Pyrimidines with two poly-haloalkyl groups were obtained by the reaction of methyl ketimines with an excess of trichloroacetonitrile, trifluoroacetonitrile and 2,2,3,3-tetrafluoropropionitrile. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Reactions of 1,3,3-trimethyl-3,4-dihydroisoquinolines with polyhaloalkanonitriles
  作者：V. Ya. Sosnovskikh、B. I. Usachev、Yu. V. Shklyaev

  DOI：10.1023/b:rucb.0000042281.14105.53

  日期：2004.6

  The reactions of 1,3,3-trimethyl-3,4-dihydroisoquinolines with halogenated nitriles afford beta-aminovinylimines, which undergo acid hydrolysis to form 1-(polyhaloacylmethylene)-3,3-dimethyl-3,4-dihydroisoquinolines.