4-phenyl-pyrrolidine-2,3,5-trione | 6476-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-phenyl-pyrrolidine-2,3,5-trione
• 英文别名: 4-Phenyl-pyrrolidin-2,3,5-trion；4-Phenyl-pyrrolidintrion-(2,3,5)；4-Phenylpyrrolidine-2,3,5-trione
• CAS: 6476-18-2
• 化学式: C₁₀H₇NO₃
• 分子量: 189.17
• InChiKey: ZIQMDGHNRLGXRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-phenyl-pyrrolidine-2,3,5-trione 在 溴 、 硝基苯 作用下， 生成 4-(4-bromo-phenyl)-pyrrolidine-2,3,5-trione
  参考文献：
  名称：

  p-Bromophenylhydroxymaleic Imide

  摘要：

  DOI：

  10.1021/ja01263a022
• 作为产物：
  描述：

  3-氰基-3-苯基丙酮酸乙酯 在 mineral acids 作用下， 生成 4-phenyl-pyrrolidine-2,3,5-trione
  参考文献：
  名称：

  Gault; Weick, Bulletin de la Societe Chimique de France, 1922, vol. <4> 31, p. 887

  摘要：

  DOI：

文献信息

• Volhard; Henke, Justus Liebigs Annalen der Chemie, 1894, vol. 282, p. 66,81
  作者：Volhard、Henke

  DOI：——

  日期：——
• Increased blood ammonia in hypoxia during exercise in humans
  作者：H. Casas、B. Murtra、M. Casas、J. Ibáñez、J. L. Ventura、A. Ricart、F. Rodríguez、G. Viscor、L. Palacios、T. Pagés、R. Rama

  DOI：10.1007/bf03179824

  日期：2001.12

  The effect of acute hypoxia on blood concentration of ammonia ([NH3](b)) and lactate ([la(-)](b)) was studied during incremental exercise(IE), and two-step constant workload exercises (CE). Fourteen endurance-trained subjects performed incremental exercise on a cycle ergometer under normoxic (21% O-2) and hypoxic (10.4% O-2) conditions. Eight endurance-trained subjects performed two-step constant workload exercise at sea level and at a simulated altitude of 5000 m (hypobaric chamber, P-B=405 Torr; P-o2=85 Torr) in random order. In normoxia, the first step lasted 25 minutes at an intensity of 85 % of the individual ventilatory anaerobic threshold (AT(vent), (ind)) at sea level. This reduced workload was followed by a second step of 5 minutes at 115% of their AT(vent, ind). This test was repeated into a hypobaric chamber, at a simulated altitude of 5,000 m. The first step in hypoxia was at an intensity of 65 % of AT(vent, ind.), whereas workload for the second step at simulated altitude was the same as that of the first workload in normoxia (85 % of AT(vent, ind)). During IE, [NH3](b) and [la(-)](b) were significantly higher in hypoxia than in normoxia. Increases in these metabolites were highly correlated in each condition. The onset of [NH3](b) and [la(-)](b) accumulation occurred at different exercise intensity in normoxia (181W for lactate and 222W for ammonia) and hypoxia (100W for lactate and 140W for ammonia). In both conditions, during CE, [NH3](b) showed a significant increase during each of the two steps, whereas [la(-)](b) increased to a steady-state in the initial step, followed by a sharp increase above 4 mM.L-1 during the second. Although exercise intensity was much lower in hypoxia than in normoxia, [NH3](b) was always higher at simulated altitude. Thus, for the same workload, [NH3](b) in hypoxia was significantly higher (p<0.05) than in normoxia. Our data suggest that there is a close relationship between [NH3](b) and [la(-)](b) in normoxia and hypoxia during graded intensity exercises. The accumulation of ammonia in blood is independent of that of lactate during constant intense exercise. Hypoxia increases the concentration of ammonia in blood during exercise.
• On the Structure of Pyrrolidinetriones and Oxazolidinediones
  作者：Glenn S. Skinner、Charles B. Miller

  DOI：10.1021/ja01100a061

  日期：1953.2
• Bougault, Chemisches Zentralblatt, 1915, vol. 86, # I, p. 671
  作者：Bougault

  DOI：——

  日期：——
• Wislicenus; Penndorf, Chemische Berichte, 1910, vol. 43, p. 1838
  作者：Wislicenus、Penndorf

  DOI：——

  日期：——