2-(pyridin-4-yl)acetyl chloride hydrochloride | 39685-78-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(pyridin-4-yl)acetyl chloride hydrochloride
• 英文别名: pyridin-4-yl-acetyl chloride; hydrochloride；4-Pyridineacetyl chloride hydrochloride；2-pyridin-4-ylacetyl chloride;hydrochloride
• CAS: 39685-78-4
• 化学式: C₇H₆ClNO*ClH
• 分子量: 192.045
• InChiKey: IGHISDFEWCEDIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲酚 、 2-(pyridin-4-yl)acetyl chloride hydrochloride 在 N,N'-二环己基碳二亚胺 作用下， 以 吡啶 为溶剂， 反应 24.0h， 以21%的产率得到2,4,6-trimethylphenyl 4-pyridylacetate
  参考文献：
  名称：

  Jackman, Lloyd M.; Chen, Xian, Journal of the American Chemical Society, 1997, vol. 119, # 37, p. 8681 - 8684

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME
  申请人：Generos Biopharma Ltd.

  公开号：EP3960736A1

  公开（公告）日：2022-03-02

  A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt, a solvate, or a solvate of a pharmaceutically acceptable salt thereof, use thereof, and a composition containing the same. The compound is novel in structure and has good STAT5 inhibitory activity.

  由式XI表示的杂环化合物，其药用盐、溶剂合物，或其药用盐的溶剂合物，以及其用途和含有该化合物的组合物。该化合物在结构上是新颖的，并具有良好的STAT5抑制活性。
• Syn isomers of cephalosporins having .alpha.-hydroximino- or
  申请人：Glaxo Laboratories Limited

  公开号：US04024134A1

  公开（公告）日：1977-05-17

  The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

  本发明提供了新型抗生素化合物，它们是7.beta.-acylamidoceph-3-em-4-carboxylic acids及其非毒性衍生物，以及6.beta.-acylamidopenam-3-carboxylic acids及其非毒性衍生物，其特征在于酰胺基团具有结构##STR1##其中R为氢原子或有机基团，R.sup.a为氢原子或酰基。这些化合物是同构体或存在至少75％的同构体混合物。这些抗生素化合物具有高抗菌活性，对一系列革兰氏阳性和革兰氏阴性微生物具有高度稳定性，特别是对各种革兰氏阴性微生物产生的 .beta.-内酰胺酶具有高度稳定性。本发明还涉及这些化合物的使用。
• 3-Hydroxymethyl-7.beta.-(2-alkoxy-or
  申请人：Glaxo Laboratories Limited

  公开号：US04033950A1

  公开（公告）日：1977-07-05

  The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

  本发明提供了一种新型抗生素化合物，它们是7.beta.-acylamidoceph-3-em-4-carboxylic酸及其非毒性衍生物，其特征在于酰胺基团具有以下结构：##STR1##其中R是氢原子或有机基团，R.sup.a是通过碳原子连接到氧原子的醚化一价有机基团。这些化合物是同构体或存在至少75％的同构体混合物。这些抗生素化合物对一系列革兰氏阳性和阴性菌具有高抗菌活性，并具有特别高的稳定性，能够对各种革兰氏阴性菌产生的β-内酰胺酶进行抑制。本发明还涉及这些化合物的给药。
• Benzimidazole derivatives as bradykinin agonists
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US06127389A1

  公开（公告）日：2000-10-03

  This invention relates to compounds of formula: ##STR1## wherein R.sup.6, R.sup.7, R.sup.2, R.sup.2, R.sup.3 and A.sup.1 are as defined in the disclosure; and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of hypertension or the like.

  本发明涉及公式：##STR1## 其中R.sup.6，R.sup.7，R.sup.2，R.sup.2，R.sup.3和A.sup.1的定义如披露所述；以及其药学上可接受的盐，其制备过程，包括它们的制药组合物，以及在预防和/或治疗高血压或类似疾病方面的治疗方法。
• Semisynthetic Penicillins. IV. Pyridylmethylpenicillins and Related Cephalosporins
  作者：R. John. Stedman、Alice C. Swift、Libby S. Miller、Margaret M. Dolan、John R. E. Hoover

  DOI：10.1021/jm00315a017

  日期：1967.5