Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring
作者:Giuseppe Campiani、Alan P. Kozikowski、Shaomeng Wang、Liu Ming、Vito Nacci、Ashima Saxena、Bhupendra P. Doctor
DOI:10.1016/s0960-894x(98)00229-7
日期:1998.6
Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. From the modelingstudies, the catechol analogue appeared capable of replacing one of the crystallographic waters bridginghuperzine with Tyr 130 and Glu
2H OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF
申请人:DUBOIS Laurent
公开号:US20120108584A1
公开(公告)日:2012-05-03
Compounds corresponding to the formula (I)
as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof
申请人:Sanofi-Aventis
公开号:US08114899B2
公开(公告)日:2012-02-14
Compounds corresponding to the formula (I)
as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof
申请人:Sanofi-Aventis
公开号:US07501449B2
公开(公告)日:2009-03-10
Compounds corresponding to the formula (I)
as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof
申请人:Sanofi
公开号:US08258168B2
公开(公告)日:2012-09-04
Compounds corresponding to the formula (I)
as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.