bis(1,3-oxazolidin-3-yl)methane | 66204-43-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: bis(1,3-oxazolidin-3-yl)methane
• 英文别名: N,N'-methylene-bis(oxazolidine)；N,N'-Methylen-bis-oxazolidin；3,3'-Methylenebis(1,3-oxazolidine)；3-(1,3-oxazolidin-3-ylmethyl)-1,3-oxazolidine
• CAS: 66204-43-1
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: KSHKNZCWWVVNHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(1,3-oxazolidin-3-yl)methane 在 亚硝酰氯 作用下， 以 乙醚 为溶剂， 以53%的产率得到3-亚硝基-1,3-恶唑烷
  参考文献：
  名称：

  Synthesis of N-nitrosoamines by the cleavage of aminals with nitrosyl chloride

  摘要：

  DOI：

  10.1007/bf00955866
• 作为产物：
  描述：

  聚合甲醛 、 C.I.酸性橙108 以85%的产率得到
  参考文献：
  名称：

  GAFAROV A. N.; PUNEGOVA L. N.; MARCHENKO G. A.; LOGINOVA EH. I.; NOVIKOV +, IZV. AN CCCP. CEP. XIM., 1980, HO 2, 405-407

  摘要：

  DOI：

文献信息

• COMPOSITIONS OF HETEROCYCLIC COMPOUNDS AND USES AS SULFIDOGENESIS INHIBITORS
  申请人：ChampionX USA Inc.

  公开号：US20210238068A1

  公开（公告）日：2021-08-05

  The present disclosure generally relates to compositions and uses of sulfidogenesis inhibitor compounds of Formulae 1 and 2 for preventing sulfidogenesis, i.e., the reduction reaction of a sulfur-containing compound by sulfur-utilizing prokaryotes that produce sulfide species such as hydrogen sulfide, during enhanced oil recovery processes. A method for inhibiting or decreasing microbial sulfide production by sulfur-utilizing prokaryotes includes addition of an effective amount of sulfidogenesis inhibitor compounds of Formulae 1 and 2 to the fluid that is injected into a sulfidogenic reservoir system during enhanced oil recovery. For example, the compounds can be used as sulfidogenesis inhibitors in a water injection system for use in a hydrocarbon extraction system or a hydrocarbon production system. Thus, these compositions can be effectively used as inhibitors of biogenic hydrogen sulfide generation in oilfield fluids.

  本公开涉及一般与化合物的组成和用途有关，化合物的化学式为1和2，用于预防硫化作用，即硫利用原核生物通过还原反应将含硫化合物还原为产生硫化氢等硫化物种的过程，在增强油田开采过程中。通过向在增强油田开采过程中注入的流体中添加化合物的有效量来抑制或减少硫利用原核生物产生的微生物硫化物的方法包括将化合物的有效量添加到硫化作用储层系统中。例如，这些化合物可以作为硫化作用抑制剂在水注入系统中使用，用于烃类萃取系统或烃类生产系统。因此，这些组成物可以有效地用作油田流体中生物源硫化氢生成的抑制剂。
• Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
  作者：İlhami Gulçin、Malahat Abbasova、Parham Taslimi、Zübeyir Huyut、Leyla Safarova、Afsun Sujayev、Vagif Farzaliyev、Şükrü Beydemir、Saleh H. Alwasel、Claudiu T. Supuran

  DOI：10.1080/14756366.2017.1368019

  日期：2017.1.1

  synthesized by a reaction with hemiformals, which are prepared by the reaction of alcohols and formaldehyde. In this study, the inhibitory effects of these molecules were investigated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II isoenzymes (hCA I and II). Both hCA isoenzymes were significantly inhibited by the recently synthesized molecules

  含氮和硫原子的化合物可广泛用于工业，医学，生物技术和化学技术等各个领域。因此，开发了巯基苯并噻唑，巯基苯并恶唑和2-氨基噻唑的氨基甲基化和烷氧基甲基化反应。此外，巯基苯并恶唑和2-氨基噻唑的烷氧基甲基衍生物是通过与半缩醛反应合成的，半缩醛是通过醇与甲醛反应制得的。在这项研究中，研究了这些分子对乙酰胆碱酯酶（AChE），丁酰胆碱酯酶（BChE）酶和碳酸酐酶I和II同工酶（hCA I和II）的抑制作用。两种hCA同工酶均被最近合成的分子显着抑制，hCA I的Ki值在58-157 nM之间，hCA II为81-215 nM。此外，这些分子的BChE和AChE的Ki参数分别在23-88和18-78 nM范围内计算。
• Synthesis and tautomerization of hydroxylated isoflavones bearing heterocyclic hemi-aminals
  作者：Mykhaylo S. Frasinyuk、Svitlana P. Bondarenko、Volodymyr P. Khilya、Chunming Liu、David S. Watt、Vitaliy M. Sviripa

  DOI：10.1039/c4ob02137a

  日期：——

  presence of excess formaldehyde led principally to 9-(2-hydroalkyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]-oxazin-4-ones 4 and/or the tautomeric 7-hydroxy-8-(1,3-oxazepan-3-ylmethyl)-4H-chromen-4-ones 5. The ratio of these tautomers was dependent on solvent polarity, electronic effects of aryl substituents in the isoflavone and the structure of the amino alcohol. NMR studies confirmed the interconversion

  在过量甲醛存在下，羟基化异黄酮与 2-氨基乙醇、3-氨基-1-丙醇、4-氨基-1-丁醇和 5-氨基-1-戊醇的氨甲基化主要生成 9-(2-氢烷基) -9,10-二氢-4H,8H-色并[8,7-e][1,3]-恶嗪-4-酮4和/或互变异构体7-羟基-8-(1,3-oxazep​​an-3 -基甲基)-4H-色烯-4-酮 5. 这些互变异构体的比例取决于溶剂极性、异黄酮中芳基取代基的电子效应以及氨基醇的结构。 NMR 研究证实了互变异构形式的相互转化。
• A novel bicyclic system, 1,6-diaza-3,8-dioxabicyclo[4.4.1]undecane
  作者：R. G. Kostyanovsky、Yu. I. El'natanov、O. N. Krutius、I. I. Chervin、H. Zaddach、K. F. Koehler

  DOI：10.1007/bf00695844

  日期：1994.2

  Condensation of monoethanolamine with formaldehyde affords 1,6-diaza-3,8-dioxabicyclo[4.4.1]undecane andN,N′-methylene-bis(oxazolidine) in a ratio of 1∶8.

  单乙醇胺与甲醛缩合得到1,6-二氮杂-3,8-二氧杂双环[4.4.1]十一烷和N,N'-亚甲基-双(恶唑烷)的比例为1∶8。
• Novel phenolic resins
  申请人：Swedo J. Raymond

  公开号：US20050054787A1

  公开（公告）日：2005-03-10

  The invention herein disclosed comprises the use of oxazolidines, nitroalcohols, nitrones, halonitroparaffins, oxazines, azaadamantanes, hexamethylenetetramine salts, nitroamines, imidazolidines, triazines, nitrooxazolidines, and imidazolidine-oxazolidine hybrids to serve as hardeners for curing phenolic resins. The hardeners and accelerators/catalysts described in the invention can be applied in any application were phenolic resins are used, including but not limited to fiber reinforced composite applications such as pultrusion, filament winding, bulk molding compound (BMC), sheet molding compounds (SMC), vacuum assisted resin transfer, prepregs, adhesives, foundry materials, abrasives, friction materials, insulation, laminates, coatings, electronics, fire resistant, and flame-retardant end uses.

  本发明涉及使用噁唑啉、硝基醇、亚硝基、卤代硝基烷、噁唑、氮杂莽碳烷、六亚甲基四胺盐、硝基胺、咪唑啉、三嗪、硝基噁唑啉和咪唑啉-噁唑啉杂交体作为固化酚醛树脂的硬化剂。本发明所述的硬化剂和加速剂/催化剂可应用于任何酚醛树脂所用的应用中，包括但不限于纤维增强复合材料应用，如拉挤成型、纱绕成型、大块模塑料(BMC)、片状模塑料(SMC)、真空辅助树脂转移、预浸料、粘合剂、铸造材料、研磨材料、摩擦材料、绝缘材料、层压板、涂料、电子材料、防火和阻燃终端用途。