4,5-Dichloropyrimidine-2-carbonitrile | 1211589-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,5-Dichloropyrimidine-2-carbonitrile
• 英文别名: 4,5-dichloropyrimidine-2-carbonitrile
• CAS: 1211589-83-1
• 化学式: C₅HCl₂N₃
• 分子量: 173.98
• InChiKey: JIOMEDVCEASERJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PROCESSES FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS DE (CYCLOPENTYL[D]PYRIMIDIN-4-YL)PIPÉRAZINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016049414A1

  公开（公告）日：2016-03-31

  The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

  本公开涉及制备(环戊基[d]嘧啶-4-基)哌嗪化合物的过程，更具体地涉及制备(R)-4-(5-甲基-7-氧代-6,7-二氢-5H-环戊基[d]嘧啶-4-基)哌嗪及其N-保护衍生物的过程，该化合物可用作Ipatasertib的合成中间体（即(S)-2-(4-氯苯基)-1-(4-((5R,7R)-7-羟基-5-甲基-6,7-二氢-5H-环戊基[d]嘧啶-4-基)哌嗪-1-基)-3-(异丙基氨基)-丙酮）的中间体。本公开还涉及在这些过程中使用的各种化合物的中间体。
• Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：US10457648B2

  公开（公告）日：2019-10-29

  The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

  本公开涉及制备(环戊基[d]嘧啶-4-基)哌嗪化合物的工艺，更特别地涉及制备(R)-4-(5-甲基-7-氧代-6,7-二氢-5H-环戊并[d]嘧啶-4-基)哌嗪及其N-保护衍生物的工艺，这些衍生物可用作合成Ipatasertib的中间体（即、(S)-2-(4-氯苯基)-1-(4-((5R,7R)-7-羟基-5-甲基-6,7-二氢-5H-环戊并[d]嘧啶-4-基)哌嗪-1-基)-3-(异丙基氨基)-丙-1-酮)。本公开还涉及作为这些工艺中使用的中间体的各种化合物。
• MIT CALIXARENEN AUSGERÜSTETE TEXTILE MATERIALIEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG
  申请人：Deutsches Textilforschungszentrum Nord-West E.V.

  公开号：EP1483439A1

  公开（公告）日：2004-12-08
• PROCESSES FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3197875A1

  公开（公告）日：2017-08-02
• PROCESSES FOR PREPARING (CYCLOPENTYL[D]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3197875B1

  公开（公告）日：2019-08-14