1,3-dimethyl-2,6-diphenylpiperidone oxime

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,3-dimethyl-2,6-diphenylpiperidone oxime
• 英文别名: 1,3-dimethyl-2,6-diphenylpiperidin-4-one oxime；VUF14161；1,3-Dimethyl-2,6-diphenyl piperidin-4-one oxime；N-(1,3-dimethyl-2,6-diphenylpiperidin-4-ylidene)hydroxylamine
• 化学式: C₁₉H₂₂N₂O
• mdl: MFCD00845194
• 分子量: 294.396
• InChiKey: WRZFUOOSXMQGBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-dimethyl-2,6-diphenylpiperidone oxime 在 potassium dichromate 、 硫酸 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 4-氯-N-[1-(5-甲基-2-呋喃基)乙亚基氨基]苯甲酰胺
  参考文献：
  名称：

  Santhi, Asian Journal of Chemistry, 2012, vol. 24, # 6, p. 2529 - 2532

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲醛 在 盐酸羟胺 、 ammonium acetate 、 sodium acetate trihydrate 、 potassium carbonate 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 2.0h， 生成 1,3-dimethyl-2,6-diphenylpiperidone oxime
  参考文献：
  名称：

  Synthesis, spectral and antimicrobial evaluation of some novel 1-methyl-3-alkyl-2,6-diphenylpiperidin-4-one oxime carbonates

  摘要：

  Synthesis of some novel biologically active piperidin-4-one oxime carbonates from 1-methyl-3alkyl-2,6-diphenylpiperidin-4-one oximes and substituted chloroformates was carried out in the presence of potassium carbonate as base and tetrabutylammonium bromide (TBAB) as catalyst. The newly synthesized compounds were characterized by IR, H-1, C-13 NMR and LC-mass spectra. Based on the 1H NMR analysis, all the compounds were found to adopt normal chair conformation with equatorial orientation of all the substituents. For all the synthesized compounds (5a-5l) antimicrobial activity has been tested against bacterial and fungal strains using Streptomycin and Amphotericin B as standards. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.04.005

文献信息

• Convenient synthesis and NMR spectral studies of variously substituted N-methylpiperidin-4-one-O-benzyloximes
  作者：Paramasivam Parthiban、Mannangatty Rani、Senthamaraikannan Kabilan

  DOI：10.1007/s00706-008-0021-6

  日期：2009.3

  and quick reaction time. All the synthesized compounds are characterized by IR, Mass and NMR (1H NMR, 13C NMR, 1H-1H COSY, 1H-13C COSY and HMBC) spectral studies. The conformational preference of the synthesized oxime ethers with/without alkyl and aryl substituents at C-3/C-5 and C-2/C-6 is discussed using the spectral data. The observed chemical shifts and coupling constants suggest that the synthesized

  摘要通过三种不同的方法合成了一系列不同取代的N-甲基哌啶-4-酮-O-苄基肟。其中，从产率，便利性，后处理容易和快速的意义上来说，证明将2，6-二芳基哌啶-4-酮直接转化为相应的肟醚（方法A）要优于其他两种方法。反应时间。所有合成的化合物均通过IR，质谱和NMR（1 H NMR，13 C NMR，1 H- 1 H COSY，1 H- 13C COZY和HMBC）光谱研究。使用光谱数据讨论了在C-3 / C-5和C-2 / C-6处有/没有烷基和芳基取代基的肟肟醚的构象偏好。观察到的化学位移和偶联常数表明，合成的肟醚采用椅子构象，所有取代基均呈赤道取向，而船上也存在1-甲基-3-异丙基-2,6-二苯基哌啶-4-一-O-苄基肟。构象。基于NMR数据，讨论了氧化对环碳及其相关质子和烷基取代基的影响。此外，还研究了N Me基对2，6-二芳基哌啶-4-酮-O-苄基肟的影响。 图形概要
• Pyrrolo[3,2-c]piperidines
  作者：T. N. Borisova、A. V. Varalmov、N. D. Sergeeva、A. T. Soldatenkov、O. V. Zvolinskii、A. A. Astakhov、N. S. Prostakov

  DOI：10.1007/bf00475655

  日期：1987.7
• Nadar, P. Ananthakrishna; Yesudian, C. Daniel, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1985, vol. 24, # 5, p. 392 - 394
  作者：Nadar, P. Ananthakrishna、Yesudian, C. Daniel

  DOI：——

  日期：——
• Synthesis, spectral and antimicrobial evaluation of some novel 1-methyl-3-alkyl-2,6-diphenylpiperidin-4-one oxime carbonates
  作者：Rajamanickam Sivakumar、Kannan Gokula krishnan、Venugopal Thanikachalam

  DOI：10.1016/j.bmcl.2013.04.005

  日期：2013.6

  Synthesis of some novel biologically active piperidin-4-one oxime carbonates from 1-methyl-3alkyl-2,6-diphenylpiperidin-4-one oximes and substituted chloroformates was carried out in the presence of potassium carbonate as base and tetrabutylammonium bromide (TBAB) as catalyst. The newly synthesized compounds were characterized by IR, H-1, C-13 NMR and LC-mass spectra. Based on the 1H NMR analysis, all the compounds were found to adopt normal chair conformation with equatorial orientation of all the substituents. For all the synthesized compounds (5a-5l) antimicrobial activity has been tested against bacterial and fungal strains using Streptomycin and Amphotericin B as standards. (C) 2013 Elsevier Ltd. All rights reserved.
• Santhi, Asian Journal of Chemistry, 2012, vol. 24, # 6, p. 2529 - 2532
  作者：Santhi

  DOI：——

  日期：——