2-[4-(4-bromobenzamido)phenyl]benzothiazole | 313548-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(4-bromobenzamido)phenyl]benzothiazole
• 英文别名: N-[4-(1,3-benzothiazol-2-yl)phenyl]-4-bromobenzamide
• CAS: 313548-45-7
• 化学式: C₂₀H₁₃BrN₂OS
• 分子量: 409.306
• InChiKey: ZJZUMZOFGCTXRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴苯甲酸 在 氯化亚砜 、 碳酸氢钠 作用下， 以 乙醚 、 水 、 苯 为溶剂， 反应 3.0h， 生成 2-[4-(4-bromobenzamido)phenyl]benzothiazole
  参考文献：
  名称：

  Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents

  摘要：

  A new series of 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl] benzothiazole derivatives (6a-k) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at minimum inhibitory concentration (MIC) values between 100 and 6.25 mu g/ml. Compounds 6d and 6k exhibited significant antibacterial activity showing 6.25 mu g/ml MIC values against drug-resistant S. aureus and P. aeruginosa isolates, respectively.

  DOI：

  10.1007/s00044-011-9918-4

文献信息

• Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents
  作者：Kayhan Bolelli、Ismail Yalcin、Tugba Ertan-Bolelli、Selda Özgen、Fatma Kaynak-Onurdag、Ilkay Yildiz、Esin Aki

  DOI：10.1007/s00044-011-9918-4

  日期：2012.11

  A new series of 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl] benzothiazole derivatives (6a-k) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at minimum inhibitory concentration (MIC) values between 100 and 6.25 mu g/ml. Compounds 6d and 6k exhibited significant antibacterial activity showing 6.25 mu g/ml MIC values against drug-resistant S. aureus and P. aeruginosa isolates, respectively.