N-[2-(4-hydroxyphenyl)ethyl]-3,5-dimethylbenzamide | 1183628-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(4-hydroxyphenyl)ethyl]-3,5-dimethylbenzamide
• CAS: 1183628-70-7
• 化学式: C₁₇H₁₉NO₂
• 分子量: 269.343
• InChiKey: OTSJPMPDPCVGCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[2-(4-hydroxyphenyl)ethyl]-3,5-dimethylbenzamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 以0.856 g的产率得到4-[2-[(3,5-Dimethylphenyl)methylamino]ethyl]phenol
  参考文献：
  名称：

  Catalyst-Free Syntheses of [2]Rotaxanes Utilizing a Pentacoordinated Hydrosilane as an End-Capping Agent

  摘要：

  A pentacoordinated hydrosilane activated by an intramolecular nitrogen silicon dative bond was utilized as an end-capping agent for catalyst-free syntheses of [2]rotaxanes. The end-capping reaction of a pseudo[2]rotaxane bearing a salicylic acid terminus with the pentacoordinated hydrosilane readily proceeded at room temperature to produce the corresponding silyl-capped [2]rotaxane.

  DOI：

  10.1021/ol100786a
• 作为产物：
  描述：

  对羟基苯乙胺 、 3,5-二甲基苯甲酰氯 在 三乙胺 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 2.0h， 生成 N-[2-(4-hydroxyphenyl)ethyl]-3,5-dimethylbenzamide
  参考文献：
  名称：

  Catalyst-Free Syntheses of [2]Rotaxanes Utilizing a Pentacoordinated Hydrosilane as an End-Capping Agent

  摘要：

  A pentacoordinated hydrosilane activated by an intramolecular nitrogen silicon dative bond was utilized as an end-capping agent for catalyst-free syntheses of [2]rotaxanes. The end-capping reaction of a pseudo[2]rotaxane bearing a salicylic acid terminus with the pentacoordinated hydrosilane readily proceeded at room temperature to produce the corresponding silyl-capped [2]rotaxane.

  DOI：

  10.1021/ol100786a

文献信息

• Catalyst-Free Syntheses of [2]Rotaxanes Utilizing a Pentacoordinated Hydrosilane as an End-Capping Agent
  作者：Yuya Domoto、Akihiro Fukushima、Yousuke Kasuga、Shohei Sase、Kei Goto、Takayuki Kawashima

  DOI：10.1021/ol100786a

  日期：2010.6.4

  A pentacoordinated hydrosilane activated by an intramolecular nitrogen silicon dative bond was utilized as an end-capping agent for catalyst-free syntheses of [2]rotaxanes. The end-capping reaction of a pseudo[2]rotaxane bearing a salicylic acid terminus with the pentacoordinated hydrosilane readily proceeded at room temperature to produce the corresponding silyl-capped [2]rotaxane.