N,N'-diphenyldithiomalonamide | 4887-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-diphenyldithiomalonamide
• 英文别名: dithiomalonic acid dianilide；N,N'-diphenylpropanedithioamide
• CAS: 4887-74-5
• 化学式: C₁₅H₁₄N₂S₂
• 分子量: 286.422
• InChiKey: DTFFRDLIPHWQRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  88.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-diphenyldithiomalonamide 在 肼 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以96%的产率得到N,N'-diphenyl-1H-pyrazole-3,5-diamine
  参考文献：
  名称：

  Diversity-orientated synthesis of 3,5-bis(arylamino)pyrazoles

  摘要：

  The synthesis of differentially-substituted 3,5-bis(arylamino)pyrazoles has not yet been documented. During our investigation, we managed to develop a novel, entirely combinatorial synthesis of 3,5-bis(arylamino)pyrazoles relying on a simple one-pot two-step operation. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.150
• 作为产物：
  描述：

  N,N'-二(苯基)丙二酰胺 在 tetraphosphorus decasulfide 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.5h， 生成 N,N'-diphenyldithiomalonamide
  参考文献：
  名称：

  α-重氮-β-二硫代酰胺的两个环化方向。12,3，-三唑-4-碳酰胺的新重排。

  摘要：

  已经研究了通过五种不同方法生成的2-二氮杂丙二硫酰胺的环化过程。2-重氮唑隆二硫代酰胺衍生物的环境特征是以前未知的5-mereapto-1,2,3-三唑-和5-氨基-1,2,3-噻二唑-4-NR-碳硫代酰胺重排至5的原因。 -NR-氨基-1,2,3-噻二唑-4-碳硫代酰胺。给出了一系列5-氨基-1,2,3-噻二唑衍生物的NMR 1 H和13 C光谱及质谱。

  DOI：

  10.1016/s0040-4020(01)89194-8

文献信息

• Synthesis of 4-oxothiazolidine-2,5-diylidenes containing thioamide group based on dithiomalonamides
  作者：K. L. Obydennov、N. A. Golovko、M. F. Kosterina、T. A. Pospelova、P. A. Slepukhin、Yu. Yu. Morzherin

  DOI：10.1007/s11172-014-0599-2

  日期：2014.6

  An approach to the synthesis of 2-(4-oxo-3-arylthiazolidine-2,5-diylidene)-N-arylethanethioamide derivatives from N,N′-diarylmalonodithioamides includes two steps: preparation of thiazoles using the Hantzsch reaction with subsequent modification of the active methylene group by the Knoevenagel condensation or enamination using dimethylformamide dimethyl acetal (DMF-DMA). Configuration and isomerization of the double bonds in 4-oxothiazolidine-2,5-diylidenes were confirmed by 1H NMR and X-ray diffraction analysis and discussed.

  一种合成2-(4-氧代-3-苯基噻唑烷-2,5-二亚基)-N-苯基乙硫酰胺衍生物的方法包括两步：利用Hantzsch反应制备噻唑，随后通过Knoevenagel缩合或使用二甲基甲酰胺二甲基乙缩醛（DMF-DMA）进行烯胺化来修饰活性亚甲基。通过1H NMR和X射线衍射分析确认了4-氧代噻唑烷-2,5-二亚基中双键的构型和异构化，并进行了讨论。
• Alkyl 4-Aryl-6-amino-7- phenyl-3-(phenylimino)-4,7-dihydro- 3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylates: Synthesis and Agrochemical Studies
  作者：Victor V. Dotsenko、Anna E. Sinotsko、Vladimir D. Strelkov、Ekaterina A. Varzieva、Alena A. Russkikh、Arina G. Levchenko、Azamat Z. Temerdashev、Nicolai A. Aksenov、Inna V. Aksenova

  DOI：10.3390/molecules28020609

  日期：——

  enylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]- pyridine-5-carboxylates in 37-72% yields. The same compounds were prepared in 23-65% yields by ternary condensation of aromatic aldehydes, ethyl(methyl) cyanoacetate and dithiomalondianilide. The reaction mechanism is discussed. The structure of ethyl 6-amino-4-(4-methoxyphenyl)-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylate

  二硫代丙二酰苯胺（N,N'-二苯基二硫代丙二酰酰胺）与 3-芳基-2-氰基丙烯酸烷基酯在吗啉存在下于空气中发生反应，生成 6-氨基-4-芳基-7-苯基-3-(苯基亚氨基)-4,7-二氢-3H-[1,2]二硫环戊并[3,4-b]-吡啶-5-羧酸烷基酯，收率为 37-72%。通过芳香醛、氰乙酸乙酯（甲基）和二硫丙二酰苯胺的三元缩合，制备了同样的化合物，收率为 23-65%。对反应机理进行了讨论。X 射线晶体学证实了 6-氨基-4-(4-甲氧基苯基)-7-苯基-3-(苯基亚氨基)-4,7-二氢-3H-[1,2]二硫环戊并[3,4-b]吡啶-5-甲酸乙酯的结构。制备的化合物中有两种对向日葵幼苗有中等程度的生长刺激作用。在实验室和向日葵田间试验中，三种新化合物被认为是除草剂 2,4-D 的强除草安全剂。
• Reaction of N,N′-Diphenyldithiomalondiamide with Aromatic Aldehydes and Cyanoacetamide
  作者：V. V. Dotsenko、A. E. Sinotsko、E. A. Varzieva、D. S. Buryi、V. K. Vasilin、N. A. Aksenov、I. V. Aksenova

  DOI：10.1134/s1070363223100067

  日期：2023.10

  Abstract The reaction of dithiomalondianilide (N,N′-diphenyldithiomalondiamide) with aromatic aldehydes and cyanoacetamide in the presence of morpholine yielded previously undescribed 6-amino-4-aryl-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxamides.

  摘要 二硫代丙二苯胺（ N , N'-二苯基二硫代丙二胺）与芳香醛和氰基乙酰胺在吗啉存在下反应，生成先前未描述的 6-氨基-4-芳基-7-苯基-3-(苯基亚氨基)-4,7-二氢-3 H- [1,2]二硫代[3,4- b ]吡啶-5-甲酰胺。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。