(E)-(4-chlorophenyl)sulfonylethenesulfonylaceticacid methyl ester | 1155273-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(4-chlorophenyl)sulfonylethenesulfonylaceticacid methyl ester
• 英文别名: methyl 2-[(E)-2-(4-chlorophenyl)sulfonylethenyl]sulfonylacetate
• CAS: 1155273-90-7
• 化学式: C₁₁H₁₁ClO₆S₂
• 分子量: 338.79
• InChiKey: IFWBDMHUGKHLTO-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-(4-chlorophenyl)sulfonylethenesulfonylaceticacid methyl ester 在 正丁基锂 、 samarium(III) chloride 、 chloroamine-T 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 2-(4',5'-dihydro-1'-phenyl-3'-(p-chlorophenyl)-4'-(p-chlorophenylsulfonyl)pyrazol-5'-ylsulfonylmethyl)-4,5-dihydrooxazole
  参考文献：
  名称：

  Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines

  摘要：

  A new class of pyrazolyl/isoxazolyl-oxazolines and thiazolines were synthesized from E-arylsulfonylethenesulfonylacetic acid methyl ester and tested for antioxidant activity. Among the tested compounds, 14b exhibited excellent antioxidant activity when compared with the standard ascorbic acid.

  DOI：

  10.1007/s00044-013-0688-z
• 作为产物：
  描述：

  甲醇 、 (E)-(4-chlorophenyl)sulfonylethenesulfonylacetic acid 在 硫酸 作用下， 以85%的产率得到(E)-(4-chlorophenyl)sulfonylethenesulfonylaceticacid methyl ester
  参考文献：
  名称：

  新型杂环吡咯基恶二唑/噻二唑/三唑的合成与生物测定

  摘要：

  从芳基磺酰基硫磺酰基磺酸甲酯制备了新型杂环吡咯基噻二唑，吡咯基恶二唑和吡咯基三唑，并对其抗菌性和细胞毒性进行了测试。

  DOI：

  10.1016/j.ejmech.2008.04.003

文献信息

• Synthesis and bioassay of a new class of disubstituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
  作者：Mangali Madhu Sekhar、Gudi Yamini、Kuppi Reddy Gari Divya、Venkatapuram Padmavathi、Adivireddy Padmaja

  DOI：10.1007/s00044-019-02360-2

  日期：2019.7

  of all the compounds were characterized by IR, 1H NMR, 13C NMR and mass spectra. All the title compounds were tested for antimicrobial activity. The arylsulfonylethenesulfonylmethyl styryl azoles displayed higher antimicrobial activity than the aroylethenesulfonylmethyl styryl azoles. The compounds having triazole moiety showed greater activity than those with oxadiazole and thiadiazole. Amongst all

  摘要一类新的aroylethenesulfonylmethyl苯乙烯基恶二唑类/噻二唑/三唑和苯乙烯基arylsulfonylethenesulfonylmethyl恶二唑/噻二唑/三唑从合成中间体进行合成的ë -aroylethenesulfonylacetic酸甲酯，ë - arylsulfonylethenesulfonylacetic苯甲酸甲酯和取代的肉桂酸采用常规和超声方法。与常规方法相比，超声辐射法得到的所有合成化合物收率更高，反应时间更短。所有化合物的结构均通过IR，1 H NMR，13表征13 C NMR和质谱。测试所有标题化合物的抗微生物活性。芳族磺酰基磺酰基甲基苯乙烯基吡咯显示出比芳酰基乙烯磺酰基甲基苯乙烯基唑更高的抗菌活性。具有三唑部分的化合物显示出比具有恶二唑和噻二唑的化合物更高的活性。在所有测试的化合物中，未取代的和氯取代的芳磺酰基磺酰基磺酰基甲基苯乙烯基三唑被鉴
• Synthesis and bioassay of pyrrolyl oxazolines and thiazolines
  作者：V. Padmavathi、K. Mahesh、G. Dinneswara Reddy、A. Padmaja

  DOI：10.1016/j.ejmech.2010.04.010

  日期：2010.7

  A new class of sulfone linked pyrrolyl oxazolines and thiazolines were synthesized from E-arylsulfonyl-ethenesulfonylacetic acid methyl ester and studied their antimicrobial and antioxidant activities. (C) 2010 Elsevier Masson SAS. All rights reserved.
• Synthesis and antioxidant activity of pyrazolyl-oxazolines/thiazolines and isoxazolyl-oxazolines/thiazolines
  作者：Adivireddy Padmaja、Chittoor Rajasekhar、Suram Durgamma、Bhumireddy Chinnachennaiahgari Venkatesh、Venkatapuram Padmavathi

  DOI：10.1007/s00044-013-0688-z

  日期：2014.3

  A new class of pyrazolyl/isoxazolyl-oxazolines and thiazolines were synthesized from E-arylsulfonylethenesulfonylacetic acid methyl ester and tested for antioxidant activity. Among the tested compounds, 14b exhibited excellent antioxidant activity when compared with the standard ascorbic acid.
• Synthesis and bioassay of a new class of heterocycles pyrrolyl oxadiazoles/thiadiazoles/triazoles
  作者：V. Padmavathi、A.V. Nagendra Mohan、P. Thriveni、A. Shazia

  DOI：10.1016/j.ejmech.2008.04.003

  日期：2009.5

  A new class of heterocycles pyrrolyl thiadiazoles, pyrrolyl oxadiazoles and pyrrolyl triazoles were prepared from arylsulfonylethenesulfonylacetic acid methyl ester and tested for their antimicrobial and cytotoxic activities.

  从芳基磺酰基硫磺酰基磺酸甲酯制备了新型杂环吡咯基噻二唑，吡咯基恶二唑和吡咯基三唑，并对其抗菌性和细胞毒性进行了测试。