Tert-butyl 2-[(2-methylpropan-2-yl)oxy]benzoate | 85144-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 2-[(2-methylpropan-2-yl)oxy]benzoate
• CAS: 85144-30-5
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: WFZDOIDSYIILLH-UHFFFAOYSA-N

物化性质

• 沸点：
  320.5±15.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 2-[(2-methylpropan-2-yl)oxy]benzoate 在 cerium(III) chloride 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 3.5h， 以91%的产率得到水杨酸
  参考文献：
  名称：

  Selective Deprotection of N-Boc-Protected tert-Butyl Ester Amino Acids by the CeCl₃·7H₂O−NaI System in Acetonitrile

  摘要：

  DOI：

  10.1021/jo010010y
• 作为产物：
  描述：

  水杨酸 、 N,N-二甲基甲酰胺二叔丁基缩醛 以3%的产率得到
  参考文献：
  名称：

  WIDMER, U., SYNTHESIS, 1983, N 2, 135-136

  摘要：

  DOI：

文献信息

• [EN] TARGETING DIAZO PRODRUGS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES<br/>[FR] CIBLAGE DE PROMÉDICAMENTS DIAZO POUR LE TRAITEMENT DE MALADIES GASTRO-INTESTINALES
  申请人：TRINITY COLLEGE DUBLIN

  公开号：WO2009003970A1

  公开（公告）日：2009-01-08

  Provided herein are compounds, compositions and methods for decreasing NFkB DNA-binding activity in a patient comprising administering of a therapeutically effective amount of a compound or composition of the application to the patient to reduce, alleviate or treat various gastrointestinal diseases, such as inflammatory bowel disease (IBD).

  本文提供了一种减少患者NFkB DNA结合活性的化合物、组合物和方法，包括向患者施用本申请的化合物或组合物的治疗有效量，以减少、缓解或治疗各种胃肠疾病，如炎症性肠病（IBD）。
• DERIVATIVES OF 4- OR 5-AMINOSALICYLIC ACID
  申请人：WALLACE JOHN L.

  公开号：US20110098257A1

  公开（公告）日：2011-04-28

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及包含这些4-或5-氨基水杨酸衍生物作为活性成分的制药组合物，用于治疗肠道疾病，如炎症性肠病（IBD）和肠易激综合征（IBS），以及预防/治疗结肠癌。更具体地说，这些衍生物包括通过偶氮键、酯键、酸酐、硫酯键或酰胺键连接到4-或5-氨基水杨酸分子上的释放硫化氢的基团。此外，本发明还提供了制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
• Toner and developer compositions
  申请人：XEROX CORPORATION

  公开号：EP0603435A1

  公开（公告）日：1994-06-29

  A toner composition contains resin, pigment and an aluminum hydroxide charge additive, or the hydrates thereof. The charge additive may be of the formula    or the hydrate thereof    or    or the hydrate thereof wherein R₁ is selected from the group consisting of hydrogen and alkyl, and n is zero, 1, 2, 3, or 4.

  调色剂组合物包含树脂、颜料和氢氧化铝电荷添加剂或其水合物。 电荷添加剂的化学式如下 或其水合物 或 或其水合物 其中 R₁ 选自氢和烷基组成的组，n 为零、1、2、3 或 4。
• Electrostatic image-developing toner, fine powdery titanium oxide, and hydrophobic fine powdery titanium oxide
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0674237A1

  公开（公告）日：1995-09-27

  A toner for developing an electrostatic image, which comprises a colorant-containing particulate resin and a treated fine powdery material prepared by treating fine powdery titanium oxide with a silane-type organic compound, where the fine powdery titanium oxide is mainly composed of a TiO₂ component and a Ti(OR)m(OH)n component wherein R is a hydrocarbon group, m and n are respectively an integer of from 0 to 4, and m + n is 4.

  一种用于显影静电图像的调色剂，它包括含着色剂的微粒树脂和通过用硅烷类有机化合物处理细粉状氧化钛而制备的处理过的细粉状材料，其中细粉状氧化钛主要由 TiO₂ 成分和 Ti(OR)m(OH)n 成分组成，其中 R 是烃基，m 和 n 分别是 0 到 4 的整数，m + n 是 4。
• PLASMA STERILIZATION INDICATOR
  申请人：Hogy Medical CO., LTD.

  公开号：EP2253334A1

  公开（公告）日：2010-11-24

  The disclosed is a novel indicator for plasma sterilization which utilizes an azo dye which has been known and used for preparing indicator for ethylene oxide gas sterilization and indicator for heat sterilization, and which exhibits a quick change of color upon the cold plasma sterilization process with using a oxidizing gas such as hydrogen peroxide, the change of color being indicated as a clear change of the color tone. The azo dye which has been known and used for preparing indicator for ethylene oxide gas sterilization and indicator for heat sterilization is used in combination with a compound containing a mercapto group or a dithiocarbamyl group therein as the compound capable of reacting with the azo dye upon the plasma sterilization treatment, and thereby bringing discoloration into the azo dye. Moreover, in combination with them, a polyhydric phenol compound or an aromatic carboxylic acid may be further used as antifading agent for discolored azo dye which is produced during the plasma sterilization process in order to stabilize the occurrence of discoloration.

  本发明公开了一种新型等离子灭菌指示剂，该指示剂利用一种已知的、用于制备环氧乙烷气体灭菌指示剂和热灭菌指示剂的偶氮染料，在使用过氧化氢等氧化性气体进行冷等离子灭菌处理时显示出快速的颜色变化，颜色变化表现为色调的明显改变。已知的用于制备环氧乙烷气体灭菌指示剂和热灭菌指示剂的偶氮染料与含有巯基或二硫代氨基甲酰基的化合物结合使用，这种化合物在等离子灭菌处理时能与偶氮染料发生反应，从而使偶氮染料褪色。此外，与它们结合使用时，还可进一步使用多羟基酚化合物或芳香族羧酸作为等离子灭菌过程中产生的变色偶氮染料的防褪色剂，以稳定变色的发生。