5-(2-羟基乙基)呋喃-2(3h)-酮 | 878007-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 中文名称: 5-(2-羟基乙基)呋喃-2(3h)-酮
• 英文名称: 5-(2-hydroxy-ethyl)-3H-furan-2-one
• 英文别名: 5-(2-Hydroxyethyl)furan-2(3H)-one；5-(2-hydroxyethyl)-3H-furan-2-one
• CAS: 878007-08-0
• 化学式: C₆H₈O₃
• 分子量: 128.128
• InChiKey: CPFWDKHAGLQDFF-UHFFFAOYSA-N

物化性质

• 沸点：
  349.5±17.0 °C(Predicted)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  5-(2-羟基乙基)呋喃-2(3h)-酮 生成 2-(2-羟乙基)-2H-呋喃-5-酮
  参考文献：
  名称：

  Lactone derivative and its manufacturing method

  摘要：

  一种新的内酯衍生物，其化学结构式(I)如下所示。

  公开号：

  US20060058536A1
• 作为产物：
  描述：

  6-hydroxy-4-oxohexanoic acid 生成 5-(2-羟基乙基)呋喃-2(3h)-酮
  参考文献：
  名称：

  Lactone derivative and its manufacturing method

  摘要：

  一种新的内酯衍生物，其化学结构式(I)如下所示。

  公开号：

  US20060058536A1

文献信息

• HETEROCYCLIC AMIDES AS ROCK INHIBITORS
  申请人：Leysen Dirk

  公开号：US20120322801A1

  公开（公告）日：2012-12-20

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地说是ROCK抑制剂，包括这些抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这些抑制剂在治疗和预防疾病方面的用途。特别是，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这些抑制剂在治疗和预防疾病方面的用途。此外，本发明还涉及治疗和使用所述化合物制造药物的方法，应用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• NOVEL ROCK INHIBITORS
  申请人：Amakem NV

  公开号：US20130252975A1

  公开（公告）日：2013-09-26

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地，是ROCK抑制剂，包括这种抑制剂的组合物，特别是制药组合物，并且涉及这种抑制剂在治疗和预防疾病方面的用途。特别地，本发明涉及新的ROCK抑制剂，包括这种抑制剂的组合物，特别是制药组合物，并且涉及这种抑制剂在治疗和预防疾病方面的用途。此外，本发明还涉及使用该化合物的治疗方法和制造药物的用途，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• Rock inhibitors
  申请人：Amakem NV

  公开号：US08912209B2

  公开（公告）日：2014-12-16

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地涉及ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及这些抑制剂在治疗和预防疾病中的用途。特别地，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及这些抑制剂在治疗和预防疾病中的用途。此外，本发明涉及治疗方法和使用上述化合物制造药物的方法，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• Heterocyclic amides as rock inhibitors
  申请人：Leysen Dirk

  公开号：US08815873B2

  公开（公告）日：2014-08-26

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地说是ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及在治疗和预防疾病方面使用这些抑制剂的用途。特别地，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及在治疗和预防疾病方面使用这些抑制剂的用途。此外，本发明还涉及使用该化合物的治疗方法和用于制造药物的应用，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• [EN] HETEROCYCLIC AMIDES AS ROCK INHIBITORS<br/>[FR] AMIDES HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE ROCK
  申请人：AMAKEM NV

  公开号：WO2011107608A8

  公开（公告）日：2012-05-03