2,4,6-triphenyl-1,3,5-trioxa-3,4,6-triphosphinane-2,4,6-trioxide | 57156-84-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,6-triphenyl-1,3,5-trioxa-3,4,6-triphosphinane-2,4,6-trioxide
• 英文别名: metaphenylphosphonate；1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-triphenyl-, 2,4,6-trioxide；2,4,6-triphenyl-1,3,5,2λ5,4λ5,6λ5-trioxatriphosphinane 2,4,6-trioxide
• CAS: 57156-84-0
• 化学式: C₁₈H₁₅O₆P₃
• 分子量: 420.235
• InChiKey: BAMIGUAXXACTCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲醇 、 2,4,6-triphenyl-1,3,5-trioxa-3,4,6-triphosphinane-2,4,6-trioxide 生成 苯基膦酸甲酯
  参考文献：
  名称：

  单体芳基二氧代膦烷（“间膦酸酯”）的产生和捕获

  摘要：

  环状亚膦酸酯（6）的气相热解生成单体偏膦酸酯（7），这是通过与相邻苯基的分子内捕获反应证明的，从而以高收率获得了5-羟基二苯甲酰基5-氧化物（8）。

  DOI：

  10.1039/c39830000857
• 作为产物：
  描述：

  Woollins 试剂 在 氧气 作用下， 以 甲苯 为溶剂， 生成 2,4,6-triphenyl-1,3,5-trioxa-3,4,6-triphosphinane-2,4,6-trioxide
  参考文献：
  名称：

  New Reactions of Selenocarboxylates

  摘要：

  By treatment with Woollins' reagent in toluene solution, carboxylic acids are converted to selenocarboxylic acids. The latter react in situ to provide new products of acid- or base-promoted substitution, addition, and amidation.

  DOI：

  10.1021/ol047889z

文献信息

• Ring-Opening Polymerization of Cyclic Phosphonates: Access to Inorganic Polymers with a P^V–O Main Chain
  作者：Marius I. Arz、Vincent T. Annibale、Nicole L. Kelly、John V. Hanna、Ian Manners

  DOI：10.1021/jacs.8b13435

  日期：2019.2.20

  class of inorganic polymeric materials featuring a main chain consisting of PV-O bonds and aryl side groups, which was obtained with >70 repeat units by ring-opening polymerization of cyclic phosphonates. This monomer-polymer system was found to be dynamic in solution enabling selective depolymerization under dilute conditions, which can be tuned by varying the substituents. The polymers show high

  我们描述了一类新的无机聚合物材料，其主链由 PV-O 键和芳基侧基组成，通过环状膦酸酯的开环聚合获得 >70 个重复单元。发现这种单体-聚合物系统在溶液中是动态的，能够在稀释条件下进行选择性解聚，这可以通过改变取代基进行调节。该聚合物对重量损失表现出高热稳定性，并且可以很容易地制成自立薄膜。还描述了环状 6 和 12 元环前体的结构特征。
• [EN] SYNTHESIS OF TELAPREVIR AND BOCEPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF INCLUDING ß-AMINO ACIDS PREPARED VIA MUKAIYAMA ALDOL ADDITION<br/>[FR] SYNTHÈSE DE TÉLAPRÉVIR ET DE BOCÉPRÉVIR, OU DE SELS OU DE SOLVATES PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI ET PRODUITS INTERMÉDIAIRES CORRESPONDANTS, NOTAMMENT DES ACIDES SS-AMINÉS, PRÉPARÉS PAR ADDITION ALDOLIQUE DE MUKAIYAMA
  申请人：SANDOZ AG

  公开号：WO2013189980A1

  公开（公告）日：2013-12-27

  The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

  该发明涉及用于制备特拉普韦和波司韦以及其中间体的合成路线，以及除特拉普韦以外的肽。合成路线基于硅烯醇醚或烯醇酸盐与亚胺的Mukaiyama醛缩加反应。该发明还涉及用于制备特拉普韦/波司韦或其他肽的新型中间体。
• [EN] PROCESS FOR THE SYNTHESIS OF TELAPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE DE TÉLAPRÉVIR, OU DE SELS PHARMACEUTIQUEMENT ACCEPTABLES OU SOLVATES DE CELUI-CI AINSI QUE DE PRODUITS INTERMÉDIAIRES DE CELUI-CI
  申请人：SANDOZ AG

  公开号：WO2013135870A1

  公开（公告）日：2013-09-19

  The invention relates to a process for the preparation of telaprevir, or a pharmaceutically acceptable salt or solvate thereof, wherein the process requires a smaller number of process steps and/or does not require the use of toxic and instable compounds compared to the known processes. Another embodiment refers to telaprevir, or a pharmaceutically acceptable salt or solvate thereof as well as to intermediate products for preparation of the same, wherein the afore-mentioned products are obtained by the process described herein.

  该发明涉及一种制备特拉普韦的过程，或其药用可接受的盐或溶剂化物，其中该过程需要较少的步骤和/或与已知过程相比不需要使用有毒和不稳定的化合物。另一种实施方式涉及特拉普韦，或其药用可接受的盐或溶剂化物，以及用于制备相同的中间产物，其中上述产品是通过本文描述的过程获得的。
• [EN] PROCESS FOR PREPARING ß-AMINO ACID DERIVATIVES AND USE OF SAID PROCESS FOR PREPARING TELAPREVIR<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS D'ACIDES SS-AMINO ET UTILISATION DUDIT PROCÉDÉ POUR LA PRÉPARATION DE TÉLAPRÉVIR
  申请人：SANDOZ AG

  公开号：WO2013189978A1

  公开（公告）日：2013-12-27

  The invention relates to a process for preparing β-amino acid derivatives, which process can be used for the preparation of telaprevir or a pharmaceutically acceptable salt or solvate thereof, wherein the process includes an organocatalytic epoxidation reaction which avoids the use of titanium catalysts and thus avoids contamination of the final product with titanium as present in known products. Another embodiment refers to telaprevir a pharmaceutically acceptable salt or solvate thereof as well as to an intermediate product for preparation of the same, wherein the afore-mentioned products are obtained by the process described herein.

  本发明涉及一种制备β-氨基酸衍生物的方法，该方法可用于制备特拉普雷韦或其药学上可接受的盐或溶剂，其中该方法包括一种有机催化环氧化反应，避免使用钛催化剂，从而避免了已知产品中存在的钛对最终产品的污染。另一种实施形式涉及特拉普雷韦的药学上可接受的盐或溶剂，以及用于制备该产品的中间产物，其中上述产品是通过本文所述的方法获得的。
• [EN] PROCESS FOR THE PREPARATION AND ISOLATION OF (S)-3-AMINO-N-CYCLOPROPYL-2,2-DIALKOXYHEXANAMIDE AND (S)-TERT-BUTYL(1-(CYCLOPROPYLAMINO)-2,2-DIALKOXY-1-OXOHEXAN-3-YL)CARBAMATE AND USE THEREOF FOR THE PREPARATION OF TELAPREVIR<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION ET L'ISOLEMENT DE (S)-3-AMINO-N-CYCLOPROPYL-2,2-DIALCOXYHEXANAMIDE ET DE (S)-(1-(CYCLOPROPYLAMINO)-2,2-DIALCOXY-1-OXOHEXAN-3-YL)CARBAMATE DE TERT-BUTYLE ET SON UTILISATION POUR LA PRÉPARATION DE TÉLAPRÉVIR
  申请人：SANDOZ AG

  公开号：WO2015036522A1

  公开（公告）日：2015-03-19

  The present invention refers to processes for preparing (1S,3aR,6aS)-2-[(2Sv)-2-[[(2S)-2- Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c] pyrrol-1-carboxamid via novel cyclic anhydrides as intermediates. The cyclic anhydrides can easily be reacted with cyclopropylamine to provide the intermediates (S)-3-Amino-N-cyclopropyl-2,2-dialkoxyhexanamide and (S)-tert-Butyl (1-(cyclopropylamino)-2,2-dialkoxy-1-oxohexan-3-yl)carbamate. The present invention also refers to intermediates of the process for preparing telaprevir and processes for the synthesis of said intermediates.

  本发明涉及使用新型环酐中间体制备(1S,3aR,6aS)-2-[(2Sv)-2-[[(2S)-2-环己基-2-(吡嗪-2-羰基氨基)乙酰]氨基]-3,3-二甲基丁酰]-N-[(3S)-1-(环丙基氨基)-1,2-二氧己烷-3-基]-3,3a,4,5,6,6a-六氢-1H-环戊[c]吡咯-1-羧酰胺的方法。这些环酐中间体可以轻易地与环丙基胺反应，提供中间体(S)-3-氨基-N-环丙基-2,2-二烷氧基己酰胺和(S)-叔丁基(1-(环丙基氨基)-2,2-二烷氧基-1-氧代己烷-3-基)氨基甲酸酯。本发明还涉及用于制备特拉普雷韦中间体的方法以及合成该中间体的过程。